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108-65-6

Basic Information
CAS No.: 108-65-6
Name: 1-Methoxy-2-propyl acetate
Molecular Structure:
Molecular Structure of 108-65-6 (1-Methoxy-2-propyl acetate)
Formula: C6H12O3
Molecular Weight: 132.159
Synonyms: 2-Propanol,1-methoxy-, acetate (6CI,7CI,8CI,9CI);1-Methoxy-2-acetoxypropane;1-Methoxy-2-propanol acetate;2-Acetoxy-1-methoxypropane;2-Methoxy-1-methylethyl acetate;KR 20;NSC 2207;PGMEA;Propylene glycol 1-methyl ether 2-acetate;1-Methoxy-2-propyl acetate;
EINECS: 203-603-9
Density: 0.959 g/cm3
Melting Point: -87 °C
Boiling Point: 154.8 °C at 760 mmHg
Flash Point: 47.9 °C
Solubility: 19.8 g/L (25 °C) in water
Appearance: colourless liquid
Hazard Symbols: ToxicT,IrritantXi
Risk Codes: 61-10-36
Safety: 53-25-45
Transport Information: UN 3271 3/PG 3
PSA: 35.53000
LogP: 0.58440
Synthetic route
2589-57-3

2-(1-methoxycarbonyl-1-methylethylazo)-2-methylpropionic acid methyl ester

108-65-6

propylene glycol methyl ether acetate

Conditions
ConditionsYield
In methanol; hexane; butanone60%
In methanol; hexane; water; butanone60%
107-98-2

1-methoxy-2-propanol

108-24-7

acetic anhydride

108-65-6

propylene glycol methyl ether acetate

124-41-4

sodium methylate

108-24-7

acetic anhydride

75-56-9, 16033-71-9

methyloxirane

108-65-6

propylene glycol methyl ether acetate

Conditions
ConditionsYield
(i), (ii) /BRN= 385737/; Multistep reaction;
79-41-4

poly(methacrylic acid)

112-55-0

1-dodecylthiol

108-65-6

propylene glycol methyl ether acetate

107-98-2

1-methoxy-2-propanol

64-19-7

acetic acid

108-65-6

propylene glycol methyl ether acetate

Conditions
ConditionsYield
at 98℃; under 130.002 Torr; Concentration;
80-48-8

methyl p-toluene sulfonate

108-65-6

propylene glycol methyl ether acetate

Conditions
ConditionsYield
With dimethyl sulfate
64-67-5

diethyl sulfate

108-65-6

propylene glycol methyl ether acetate

Conditions
ConditionsYield
With dimethyl sulfate
107-98-2

1-methoxy-2-propanol

105-46-4

sec-Butyl acetate

108-65-6

propylene glycol methyl ether acetate

Conditions
ConditionsYield
With sodium methylate at 135℃; for 5h;
108-65-6

propylene glycol methyl ether acetate

A

4188-68-5

methyl (Z)-prop-1-enyl ether

B

4188-69-6

(E)-1-Methoxy-1-propen

C

627-40-7

methylallylether

Conditions
ConditionsYield
at 500℃;
108-65-6

propylene glycol methyl ether acetate

A

4188-68-5

methyl (Z)-prop-1-enyl ether

B

627-40-7

methylallylether

Conditions
ConditionsYield
at 500℃;
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Consensus Reports

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of PROPYLENE GLYCOL MONOMETHYL ETHER ACETATE.

Standards and Recommendations

DFG MAK: 50 ppm

Specification

The 1-Methoxy-2-propyl acetate, with the CAS registry number 108-65-6,is also known as 1,2-Propanediol monomethyl ether acetate; Propylene glycol methyl ether acetate; MPA. It belongs to the product categories of Solvent Bottles;Solvent Packaging Options;Solvents.This chemical's molecular formula is C6H12O3 and molecular weight is 132.16. What's more,Its systematic name is 2-Methoxy-1-methylethyl acetate.It is colourless liquid,which is stable,flammable,incompatible with strong oxidizing agents,acids,bases.

Physical properties about 1-Methoxy-2-propyl acetate are:
(1)ACD/LogP:  0.481; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  0.48; (4)ACD/LogD (pH 7.4):  0.48; (5)ACD/BCF (pH 5.5):  1.37; (6)ACD/BCF (pH 7.4):  1.37; (7)ACD/KOC (pH 5.5):  43.49; (8)ACD/KOC (pH 7.4):  43.49; (9)#H bond acceptors:  3; (10)#H bond donors:  0; (11)#Freely Rotating Bonds:  4; (12)Index of Refraction:  1.399; (13)Molar Refractivity:  33.325 cm3; (14)Molar Volume:  137.797 cm3; (15)Surface Tension:  26.5 dyne/cm; (16)Density:  0.959 g/cm3; (17)Flash Point:  47.856 °C; (18)Enthalpy of Vaporization:  39.154 kJ/mol; (19)Boiling Point:  154.79 °C at 760 mmHg; (20)Vapour Pressure:  3.125 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C(OC(C)COC)C;
(2)Std. InChI:InChI=1S/C6H12O3/c1-5(4-8-3)9-6(2)7/h5H,4H2,1-3H3;
(3)Std. InChIKey:LLHKCFNBLRBOGN-UHFFFAOYSA-N.

Uses of 1-Methoxy-2-propyl acetate:
1-Methoxy-2-propyl acetateis used as a solvent in the manufacture of coating polymers such as cellulose acetate butyrate,  epoxy resins, nitrocellulose, and phenoxy resins; cosmetic formulations, agricultural products, ink formulations, textile and adhesive products. It is also used as retarder solvent in lacquers, baking elements etc.

Safety Information of 1-Methoxy-2-propyl acetate:
The 1-Methoxy-2-propyl acetate is flammable ,so it need far away from the combustion source.It is irritating to the eyes ,avoid contact with eyes.And it may cause harm to the unborn child.In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .Avoid exposure - obtain special instruction before use.

The toxicity data of 1-Methoxy-2-propyl acetate as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 750mg/kg (750mg/kg)   National Technical Information Service. Vol. AD691-490,
rabbit LD50 skin > 5gm/kg (5000mg/kg)   Dow Chemical Company Reports. Vol. MSD-1582,
rat LD50 oral 8532mg/kg (8532mg/kg)   Dow Chemical Company Reports. Vol. MSD-1582,