CAS No.135-19-3,2-Naphthol Suppliers,MSDS download

Products Categories

Pharmaceutical (171)
Others (72)
Organic Chemicals (60)
Dyestuff and Pigment (30)
Materials (11)
Reagent (5)
Basic Inorganic Chemicals (4)
Plant Extract (4)
(2)
Agrochemicals (1)

Basic Information

Molecular Structure:
CAS No.:	135-19-3
Name:	2-Naphthol
Article Data:	645
Cas Database

Formula:	C₁₀H₈O
Molecular Weight:	144.173
Synonyms:	2-Naphthol(8CI);2-Hydroxynaphthalene;Azogen Developer A;Betanaphthol;C.I. 37500;C.I. Developer 5;Developer AMS;Developer BN;Isonaphthol;NSC 2044;Naphthol B;b-Hydroxynaphthalene;b-Naphthol;b-Naphthyl alcohol;
EINECS:	205-182-7
Density:	1.182 g/cm³
Melting Point:	120-122 °C(lit.)
Boiling Point:	285.499 °C at 760 mmHg
Flash Point:	144.002 °C
Solubility:	Very slightly soluble in water: 1 g/L (20 °C)
Appearance:	broken white shiny flakes or white powder
Hazard Symbols:	Xn,N
Risk Codes:	20/22-50
Safety:	24/25-61
Transport Information:	UN 3077 9/PG 3
PSA:	20.23000
LogP:	2.54540

Synthetic route

: 1523-11-1
naphthalen-2-yl acetate

: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With lipase of Pseudomonas sp; water In various solvent(s) at 25℃; for 5h; Hydrolysis; deacetylation;	100%
With sodium hydrogen telluride; acetic acid In ethanol for 0.5h; Heating;	98%
With 2,2-dibutyl-1,3,2-dioxastannane; cesium fluoride In N,N-dimethyl-formamide at 20℃; for 0.5h;	98%

: 91902-97-5
ethyl (naphthalene-2-yl)carbonate

: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With sodium hydrogen telluride In ethanol for 0.5h; Quantum yield; Heating; buffer: deoxygen. acetic acid;	100%
With potassium tert-butylate; hydrogen; C16H18BrCoINO2 In dibutyl ether at 160℃; under 45004.5 Torr; for 20h; Sealed tube; Autoclave;	75%

: 93-44-7
2-naphthyl benzoate

: 137-07-5
2-amino-benzenethiol

A: 883-93-2
2-Phenylbenzothiazole

B: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; potassium carbonate at 100℃; for 0.75h; Hydrolysis; cyclization; debenzoylation;	A n/a B 100%

...Expand

: 1503-86-2
2-naphthyl pivalate

: 137-07-5
2-amino-benzenethiol

A: 17626-88-9
2-(tert-butyl)benzo[d]thiazole

B: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; potassium carbonate at 100℃; for 2h; Hydrolysis; cyclization;	A n/a B 100%

...Expand

: 93-44-7
2-naphthyl benzoate

: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one for 0.5h; Heating;	100%
With potassium fluoride; thiophenol In 1-methyl-pyrrolidin-2-one for 0.5h; Heating;	92%
With HEPES buffer; human liver microsomal carboxylesterase 1 In dimethyl sulfoxide pH=7.4; Enzyme kinetics; Further Variations:; Reagents;

: 15231-91-1
6-bromo-naphthalen-2-ol

: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With triethylamine In isopropyl alcohol UV-irradiation;	100%

: 30784-04-4
2-naphthyl tetrahydro-2H-pyran-2-yl ether

: 135-19-3
β-naphthol

Conditions

Conditions	Yield
poly(4-vinylpyridinium) p-toluenesulfonate In tetrahydrofuran; ethanol at 75℃; for 20h; Hydrolysis;	99%
silica-supported prop-1-ylsulfonic acid In methanol	99.4%
With methanol; zirconium(IV) chloride at 20℃; for 6h;	96%

: 580-13-2
2-bromonaphthalene

: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With copper(I) oxide; tetra(n-butyl)ammonium hydroxide; 1,10-phenanthroline-4,7-diol In water at 110℃; for 24h; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry;	99%
With copper(l) iodide; potassium hydroxide In water at 120℃; for 12h; Inert atmosphere;	96%
With tris(6,6'-diamino-2,2'-bipyridine); 4,4-diphenyl-1,3,5,7,8-pentamethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene; Br2Ni*3H2O; water; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 24h; Glovebox; Irradiation; Inert atmosphere;	92%

: 3698-15-5
2-(allyloxy)naphthalene

: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With chloro-trimethyl-silane; Ti(OiPr)[{(O-2,4-Me2C6H2)-6-CH2}3N]; magnesium In tetrahydrofuran at 40 - 50℃; for 12h; Inert atmosphere; regioselective reaction;	99%
With chloro-trimethyl-silane; sodium iodide In acetonitrile for 0.0333333h;	98%
With chloro-trimethyl-silane; sodium cyanoborohydride In acetonitrile at 20℃; for 0.25h; ether cleavage;	98%

: 135-19-3
β-naphthol

Conditions

Conditions	Yield
With bismuth(lll) trifluoromethanesulfonate In methanol at 20℃; for 0.0333333h;	99%
montmorillonite K-10 for 0.0833333h; Solid phase reaction; desilylation; microwave irradiation;	98%
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.15h; Green chemistry;	98%

Raw Materials

773-90-0

7385-85-5

4832-17-1

92-70-6

120-23-0

28269-50-3

62790-91-4

107-02-8

Downstream Products

92-44-4

Total:211 Page 1 of 6 1 2 3 4 5 6 Next>>

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Uses

2-Naphthol (CAS NO.135-19-3) is an intermediate of naphthalene acid which is a plant growth regulator.
2-Naphthol is used as a feed preservative and analytical reagent.
2-Naphthol is an important organic raw material and dyes intermediate, for the manufacture of Tobias acid, butyric acid, β-naphthol-3-carboxylic acid, and used to manufacture antioxidant, Antioxidant DNP, and other antioxidant, organic pigments and fungicides.

Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Specification

The 2-Naphthol, with the CAS registry number 135-19-3,is also known as 2-Hydroxynaphthalene; 2-Naphthalenol; beta-Hydroxynaphthalene. It belongs to the product categories of Organic Building Blocks;Oxygen Compounds;Particles and Stains.Its EINECS number is 205-182-7. This chemical's molecular formula is C₁₀H₈O and molecular weight is 144.17. What's more,Its systematic name is 2-Naphthalenol.It is a white or off-white powder with a slight which is stable, Combustible,dust may form explosive mixture with air,incompatible with strong oxidizing agents,phenol.It is an important organic raw material and dyes intermediate, for the manufacture of Tobias acid, butyric acid, β-naphthol-3-carboxylic acid, and used to manufacture antioxidant, Antioxidant DNP, and other antioxidant, organic pigments and fungicides.

Physical properties about 2-Naphthol are:
(1)ACD/LogP: 2.724; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.72; (4)ACD/LogD (pH 7.4): 2.72; (5)ACD/BCF (pH 5.5): 69.26; (6)ACD/BCF (pH 7.4): 68.80; (7)ACD/KOC (pH 5.5): 722.79; (8)ACD/KOC (pH 7.4): 718.00; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.678; (13)Molar Refractivity: 45.977 cm3; (14)Molar Volume: 121.979 cm3; (15)Surface Tension: 51.0940017700195 dyne/cm; (16)Density: 1.182 g/cm3; (17)Flash Point: 144.002 °C; (18)Enthalpy of Vaporization: 54.56 kJ/mol; (19)Boiling Point: 285.499 °C at 760 mmHg; (20)Vapour Pressure: 0.0020000000949949 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:c1ccc2cc(ccc2c1)O;
(2)Std. InChI:InChI=1S/C10H8O/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7,11H;
(3)Std. InChIKey:JWAZRIHNYRIHIV-UHFFFAOYSA-N.

The toxicity data of 2-Naphthol are as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	100mg/kg (100mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
guinea pig	LD50	oral	1335mg/kg (1335mg/kg)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 30(9), Pg. 22, 1965.
guinea pig	LDLo	subcutaneous	2670mg/kg (2670mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 186, Pg. 195, 1937.
mouse	LD50	intraperitoneal	97500mg/kg (97500mg/kg)		European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 13, Pg. 381, 1978.
mouse	LDLo	oral	100mg/kg (100mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
mouse	LDLo	subcutaneous	100mg/kg (100mg/kg)		Zeitschrift fuer Hygiene und Infektionskrankheiten. Vol. 64, Pg. 113, 1909.
rabbit	LD50	skin	> 10gm/kg (10000mg/kg)		BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 26-4/1973,
rabbit	LDLo	oral	3800mg/kg (3800mg/kg)		Yakkyoku. Pharmacy. Vol. 31, Pg. 1499, 1980.
rabbit	LDLo	subcutaneous	3gm/kg (3000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
rabbit	LDLo	unreported	3800mg/kg (3800mg/kg)		Yakkyoku. Pharmacy. Vol. 32, Pg. 605, 1981.
rat	LC50	inhalation	> 770mg/m3/1H (770mg/m3)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 26-4/1973,
rat	LD50	oral	1960mg/kg (1960mg/kg)		Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. Vol. 8, Pg. 145, 1972.
rat	LDLo	subcutaneous	2940mg/kg (2940mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SLEEP BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 186, Pg. 195, 1937.