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| CAS No.: | 138-59-0 |
|---|---|
| Name: | Shikimic acid |
| Article Data: | 38 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C7H10O5 |
| Molecular Weight: | 174.153 |
| Synonyms: | Bracken fern toxic component;3alpha,4alpha,5beta-Trihydroxy-1-cyclohexene-1-carboxylic acid;L-Shikimic acid;3,4, 5-Trihydroxy-1-cyclohexene-1-carboxylic acid;(-)-Shikimic acid;3,4,5-trihydroxycyclohexene-1-carboxylic acid;1-Cyclohexene-1-carboxylic acid, 3,4,5-trihydroxy-, (3R-(3alpha,4alpha,5beta))- (9CI);3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid; |
| EINECS: | 205-334-2 |
| Density: | 1.725 g/cm3 |
| Melting Point: | 185-187 ºC |
| Boiling Point: | 400.5 ºC at 760 mmHg |
| Flash Point: | 210.1 ºC |
| Solubility: | water: 18 g/100 mL (20 ºC) |
| Appearance: | white solid |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 22-24/25-36-26 |
| Transport Information: | N/A |
| PSA: | 97.99000 |
| LogP: | -1.51620 |
methyl shikimate
shikimic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide In tetrahydrofuran; water for 5.5h; Ambient temperature; | 97% |
| With sodium hydroxide In tetrahydrofuran; water | 96% |
| With sodium hydroxide; water In tetrahydrofuran for 1h; Ambient temperature; | 96% |
(3R,4S,5R)-3,4-Diacetoxy-5-hydroxy-cyclohex-1-enecarboxylic acid methyl ester
shikimic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide In methanol at 5 - 25℃; for 2.5h; | 90% |
| With sodium hydroxide 1.) in methanol-water, 5 deg C, 0.5h; 2.) room temp., 2h; Multistep reaction; |
(3aR,4S,7R,7aS)-methyl 4,7-dihydroxy-2,2-dimethylhexahydrobenzo[d][1,3]dioxole-5-carboxylate
shikimic acid
| Conditions | Yield |
|---|---|
| Stage #1: (3aR,4S,7R,7aS)-methyl 4,7-dihydroxy-2,2-dimethylhexahydrobenzo[d][1,3]dioxole-5-carboxylate With dmap; acetic anhydride; triethylamine In tetrahydrofuran for 3.66667h; Inert atmosphere; Stage #2: With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran for 10h; Inert atmosphere; enantioselective reaction; | 80% |
(1S,2R,6R)-4-(ethoxycarbonyl)-6-(4-nitrobenzoyloxy)-cyclohex-3-ene-1,2-diyl diacetate
shikimic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide | 65% |
shikimic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride; water at 80℃; for 3h; | 62% |
shikimic acid
| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In water | 53% |
methyl shikimate
A
shikimic acid
B
3(S),4(S),5(R)-trihydroxy-1-cyclohexene-1-carboxylic acid
C
4-hydroxy-benzoic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride; water at 100℃; for 30h; | A 8% B 21% C 21% |
| Conditions | Yield |
|---|---|
| Stage #1: D-Glucose With Bacillus pumilus ATCC 21143; oxygen In various solvent(s) at 30℃; for 96h; Microbiological reaction; Stage #2: Escherichia coli SP1.1/pJG6.181B With oxygen In various solvent(s) at 37℃; Microbiological reaction; | A n/a B 5% |
| Conditions | Yield |
|---|---|
| With cultures of escherichia coli; water at 35℃; |
3a,6,7,7a-tetrahydro-7-hydroxy-2,2-dimethyl-[3aR-(3aα,7α,7aα)]-1,3-benzodioxole-5-carboxylic acid
shikimic acid
| Conditions | Yield |
|---|---|
| With water; trifluoroacetic acid Ambient temperature; Yield given; | |
| With trifluoroacetic acid for 10h; Ambient temperature; Yield given; | |
| Multi-step reaction with 3 steps 1: CDCl3; pyridine / 48 h / Ambient temperature 2: aq. acetic acid / 2 h / 100 °C 3: aq. HCl / reflux 30 min, room temp. overnight View Scheme |
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IUPAC name: (3R,4S,5R)-3,4,5-Trihydroxycyclohexene-1-carboxylic acid
Molecular Formula: C7H10O5
Molecular Weight: 174.15 g/mol
EINECS: 205-334-2
Melting point: 185-191 °C
alpha: -180 º (c=4, H2O 25 °C)
Water solubility: 18 g/100 mL (20 °C)
Index of Refraction: 1.679
Sensitive: Hygroscopic
Merck: 14,8480
Density: 1.725 g/cm3
Flash Point: 210.1 °C
Surface Tension: 116.6 dyne/cm
Enthalpy of Vaporization: 75.28 kJ/mol
Boiling Point: 400.5 °C at 760 mmHg
Vapour Pressure: 4.45E-08 mmHg at 25 °C
Product Category of Shikimic acid (CAS NO.138-59-0): API intermediates;Chiral Reagents;Chiral Building Blocks;Simple Alcohols (Chiral);Synthetic Organic Chemistry;Natural Plant Extract
Following is the structure of Shikimic acid (CAS NO.138-59-0):
Naturally, Shikimic acid (CAS NO.138-59-0) occurring (-)-form is a major biosynthetic precursor of phenylalanine, tyrosine, and tryptophan and hence of the majority of plant alkaloids. It is also involved in the biosynthesis of lignin, flavonpids and other important aromatic substance.
| 1. | dlt-mus-ipr 1000 mg/kg | BJLSAF Botanical Journal of the Linnean Society. 73 (1976),105. | ||
| 2. | dlt-mus-orl 3200 mg/kg | NATUAS Nature. 250 (1974),348. | ||
| 3. | otr-ham:kdy 250 mg/L | TOLED5 Toxicology Letters. 19 (1983),43. | ||
| 4. | ipr-mus LD50:1000 mg/kg | NATUAS Nature. 250 (1974),348. |
Shikimic acid (CAS NO.138-59-0) has been listed as a carcinogen by IARC in Group 3. The toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.
IARC Cancer Review: Group 3 IMEMDT . IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 40 ,1986,p. 47.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Shikimic acid's safety information: Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition, it emits acrid smoke and irritating fumes.
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R37/38:Irritating to respiratory system and skin.
Safety Statements: 22-24/25-36-26
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: GW4600000
F: 3-10
HS Code: 29181980
Shikimic acid , with a CAS number of 138-59-0, known as 3R,4S,5R)-(-)-3,4,5-Trihydroxy-1-cyclohexenecarboxylic acid ; and 3,4,5-Trihydroxy-1-cyclohexene-1-carboxylic acid . And its classification code are mutation data, natural product, tumor data. Shikimic acid (CAS NO.138-59-0) could be stable under normal temperatures and pressures. And it should avoid the condition like strong oxidants. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Its hazardous polymerization has not been reported.
