CAS No.501-36-0,Resveratrol Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	501-36-0
Name:	Resveratrol
Article Data:	128
Cas Database

Formula:	C₁₄H₁₂O₃
Molecular Weight:	228.247
Synonyms:	1,3-Benzenediol,5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-;1,3-Benzenediol,5-[2-(4-hydroxyphenyl)ethenyl]-, (E)-;(E)-2-(3,5-Dihydroxyphenyl)-1-(4-hydroxyphenyl)ethene;(E)-3,4',5-Trihydroxystilbene;(E)-5-(p-Hydroxystyryl)resorcinol;3,4',5-Trihydroxy-trans-stilbene;5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol;CA 1201;Resvida;trans-Resveratrol;Natural Resveratrol Polygonum Cuspidatum Extract;100% Natural Resveratrol Polygonum Cuspidatum Extract;
EINECS:	610-504-8
Density:	1.359 g/cm³
Melting Point:	253-255 °C
Boiling Point:	449.1 °C at 760 mmHg
Flash Point:	222.3 °C
Solubility:	Soluble in water (3 mg/100mL), ethanol (50 mg/mL), DMSO (16 mg/mL), DMF (~65 mg/mL), PBS (pH 7.2) (~100µg/mL), methanol, and acetone (50 mg/mL).
Appearance:	Off-White to Tan Powder
Hazard Symbols:	Xi
Risk Codes:	37/38-41-36/38
Safety:	26-39-37/39
Transport Information:	N/A
PSA:	60.69000
LogP:	2.97380

Synthetic route

: 22255-22-7
3,5,4'-trimethoxy-trans-stilbene

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
With boron tribromide In dichloromethane at 0 - 30℃;	100%
With boron tribromide In dichloromethane at 0 - 20℃;	99%
With aluminum (III) chloride; sodium sulfate; triethylamine In chlorobenzene at 0 - 115℃; for 6.5h; Inert atmosphere;	98%

: 89946-06-5
(E)-1-(4-(benzyloxy)phenyl)-2-(3,5-bis(benzyloxy)phenyl)-ethene

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
Stage #1: (E)-1-(4-(benzyloxy)phenyl)-2-(3,5-bis(benzyloxy)phenyl)-ethene With aluminum (III) chloride; triethylamine In chlorobenzene at 0 - 80℃; for 10h; Stage #2: With water In chlorobenzene at 0℃; for 2h; Product distribution / selectivity;	100%
With aluminum (III) chloride; N,N-dimethyl-aniline at 40 - 50℃;	90%
With hydrogen In dichloromethane at 20℃; under 3750.38 Torr; for 5h;	87%

: 710969-83-8
(E)-3,5,4'-tri(benzoyloxy)styrene

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
With sodium methylate In tetrahydrofuran; methanol at 50℃; for 5h;	98%

: 1217011-33-0
(E)-4-(3,5-bis(methoxymethoxy)styryl)phenol

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 20 - 65℃; for 3h; Inert atmosphere;	97%

: 26153-38-8
3,5-dihydroxybenzaldehyde

: 68997-88-6
dimethyl (4-hydroxybenzyl)phosphonate

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
With RS004 catalyst In ethanol at 20℃; for 6h; Wittig-Horner Reaction;	97%

: 411233-11-9
4'-Acetylresveratrol

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran for 2h; Heating;	95%

: 22255-22-7, 94608-23-8, 63844-75-7
3,5,4'-trimethoxystilbene

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
Stage #1: 3,5,4'-trimethoxystilbene With boron tribromide In toluene at 0 - 20℃; for 2.03333h; Stage #2: With water; sodium hydrogencarbonate In toluene at 0℃; for 0.333333h;	92%
With aluminum (III) chloride; triethylamine In chlorobenzene at 60 - 70℃; for 0.5h; Inert atmosphere;	90%
Multi-step reaction with 2 steps 1: BBr3 2: diphenyl disulphide / tetrahydrofuran / Heating View Scheme
With pyridine hydrochloride at 190 - 195℃; for 4h;
Stage #1: 3,5,4'-trimethoxystilbene With iodine In hexane for 48h; Reflux; Stage #2: With boron tribromide In dichloromethane at 0 - 20℃; for 5h;

: 1399502-89-6
(E)-2,4,6-tribromo-3,5,4'-trihydroxystilbene

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
With sodium sulfite In water at 60℃; for 6h; Green chemistry;	90%

: 42206-94-0
triacetyl-trans-resveratrol

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran	88%
Stage #1: triacetyl-trans-resveratrol With potassium hydroxide In methanol for 1h; Inert atmosphere; Reflux; Stage #2: With hydrogenchloride In methanol; water pH=2; Inert atmosphere;	79%
With sodium methylate In tetrahydrofuran; methanol
With potassium hydroxide In methanol; ethyl acetate

: 587870-67-5
(E)-1-(3,5-di-isopropoxyphenyl)-2-(4-isopropoxyphenyl)ethene

: 501-36-0
(E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol

Conditions

Conditions	Yield
With boron trichloride In dichloromethane at -78 - -10℃;	85%

Raw Materials

836-43-1

134-96-3

Downstream Products

99-10-5

537-42-8

501-36-0

Total:451 Page 1 of 12 1 2 3 4 5 6 …12 Next>>

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Specification

The Resveratrol, with the CAS registry number 501-36-0,is also known as 3,4',5-Trihydroxy-trans-stilbene; 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol. It belongs to the product categories of Intermediates & Fine Chemicals;Pharmaceuticals;Caspases/Apoptosis;Health supplements.Its EINECS number is 501-36-0. This chemical's molecular formula is C₁₄H₁₂O₃ and molecular weight is 228.24. What's more,Its systematic name is 1,3-Benzenediol,5-(2-(4-hydroxyphenyl)ethenyl)-,(E)-.It is Off-White to Tan Powder.It is a phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis.

Physical properties about Resveratrol are:
(1)ACD/LogP: 3.139; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.14; (4)ACD/LogD (pH 7.4): 3.13; (5)ACD/BCF (pH 5.5): 143.19; (6)ACD/BCF (pH 7.4): 140.74; (7)ACD/KOC (pH 5.5): 1215.59; (8)ACD/KOC (pH 7.4): 1194.74; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 5; (12)Index of Refraction: 1.763; (13)Molar Refractivity: 69.291 cm3; (14)Molar Volume: 167.93 cm3; (15)Surface Tension: 70.7279968261719 dyne/cm; (16)Density: 1.359 g/cm3; (17)Flash Point: 222.313 °C; (18)Enthalpy of Vaporization: 73.496 kJ/mol; (19)Boiling Point: 449.115 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C;

You can still convert the following datas into molecular structure:
(1)SMILES:Oc2cc(\C=C\c1ccc(O)cc1)cc(O)c2;
(2)Std. InChI:InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+;
(3)Std. InChIKey:LUKBXSAWLPMMSZ-OWOJBTEDSA-N;

Safety Information of Resveratrol:
The Resveratrol is risk of serious damage to eyes .It is irritating to eyes ,respiratory system and skin.When you use it ,wear suitable protective clothing, gloves and eye/face protection.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.