CAS No.518-47-8,Fluorescein disodium salt Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	518-47-8
Name:	Fluorescein disodium salt
Article Data:	2
Cas Database

Formula:	C₂₀H₁₀Na₂O₅
Molecular Weight:	376.276
Synonyms:	Fluorescein,disodium salt (8CI);Fluorin (6CI,7CI);Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one,3',6'-dihydroxy-, disodium salt (9CI);11824 Yellow;3058Uranine;5(6)-Carboxyfluorescein sodium;ABCO Uranine;Abbey Uranine;AcidYellow 73;Aizen Uranine;Basacid Yellow 226;C.I. 45350;C.I. Acid Yellow 73;C Yellow 8;D and C Yellow No. 8;C Yellow No. 8;C Yellow No. 8-307225;Dinacid FlorescineceUranine;Fluo-rectal;Fluorescein LT;Fluorescein Sodium B.P;
EINECS:	208-253-0
Density:	1.601 g/cm3 (20ºC)
Melting Point:	320 °C
Boiling Point:	662.6 °C at 760 mmHg
Flash Point:	247.1 °C
Solubility:	water: 500 g/L (20 °C)
Appearance:	orange powder
Hazard Symbols:	Xi
Risk Codes:	36-36/37/38
Safety:	22-24/25-37/39-26-36/37/39-27
Transport Information:	N/A
PSA:	81.65000
LogP:	4.54220

Synthetic route

: 518-47-8
fluorescein sodium salt

: 106-95-6
allyl bromide

: 145387-24-2
allyl 2-(6-(allyloxy)-3-oxo-3H-xanthen-9-yl)benzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 48h;	37%

: 518-47-8
fluorescein sodium salt

: 15086-94-9
eosin y

Conditions

Conditions	Yield
With potassium bromate; sulfuric acid; potassium bromide In water; acetone for 2h;	1.15 g

: 518-47-8
fluorescein sodium salt

: 1621954-04-8
C47H42O10

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium iodide / N,N-dimethyl-formamide 2: dmap; dicyclohexyl-carbodiimide View Scheme

: 38771-21-0
4-bromobut-1-yne

: 518-47-8
fluorescein sodium salt

: 1621954-03-7
C24H16O5

Conditions

Conditions	Yield
With sodium iodide In N,N-dimethyl-formamide

: 518-47-8
fluorescein sodium salt

: 6-(allyloxy)-9-(2-(hydroxymethyl)phenyl)-9H-xanthen-3-ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C View Scheme

: 518-47-8
fluorescein sodium salt

: 6-(allyloxy)-2,4-dichloro-9-(2-(hydroxymethyl)phenyl)-9H-xanthen-3-ol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C View Scheme

: 518-47-8
fluorescein sodium salt

: 6'-(allyloxy)-2',4'-dichloro-3H-spiro[isobenzofuran-1,9'-xanthen]-3'-ol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C 4: chloranil / dichloromethane / 7 h / 20 °C View Scheme

: 518-47-8
fluorescein sodium salt

: 6'-(allyloxy)-2',4'-dichloro-3H-spiro[isobenzofuran-1,9'-xanthen]-3'-yl 2-methyl-2-(tritylthio)propanoate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C 4: chloranil / dichloromethane / 7 h / 20 °C 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C View Scheme

: 518-47-8
fluorescein sodium salt

: 2',4'-dichloro-6'-hydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3'-yl 2-methyl-2-(tritylthio)propanoate

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C 4: chloranil / dichloromethane / 7 h / 20 °C 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C 6: tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; methanol / dichloromethane / 20 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 6 steps
1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C
4: chloranil / dichloromethane / 7 h / 20 °C
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C
6: tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; methanol / dichloromethane / 20 °C / Inert atmosphere
View Scheme

: 518-47-8
fluorescein sodium salt

: NitroxylFluor

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C 3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C 4: chloranil / dichloromethane / 7 h / 20 °C 5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C 6: tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; methanol / dichloromethane / 20 °C / Inert atmosphere 7: trifluoroacetic acid / chloroform / 20 °C View Scheme

Yield

Multi-step reaction with 7 steps
1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
3: sodium hypochlorite; sodium hydroxide / water / 3 h / 20 °C
4: chloranil / dichloromethane / 7 h / 20 °C
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C
6: tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; methanol / dichloromethane / 20 °C / Inert atmosphere
7: trifluoroacetic acid / chloroform / 20 °C
View Scheme

Downstream Products

131205-61-3

15086-94-9

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Chemistry

The Molecular Structure of Fluorescein sodium (CAS NO.518-47-8):

Empirical Formula: C₂₀H₁₀Na₂O₅
Molecular Weight: 376.2699
IUPAC Name: disodium 2-(3-oxido-6-oxoxanthen-9-yl)benzoate
Appearance: orange powder
Product Categories: Intermediates of Dyes and Pigments;Dyes and Pigments
Nominal Mass: 376 Da
Average Mass: 376.2699 Da
Monoisotopic Mass: 376.032363 Da
Flash Point: 232.6 °C
Enthalpy of Vaporization: 95.37 kJ/mol
Boiling Point: 620.8 °C at 760 mmHg
Vapour Pressure: 5.24E-16 mmHg at 25°C
Water Solubility: 500 g/L (20 ºC)
Stability: Stable
InChI
InChI=1/C20H12O5.2Na/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24;;/h1-10,21H,(H,23,24);;/q;2*+1/p-2
Smiles
c1(c2c(oc3c1ccc(c3)[O-])cc(=O)cc2)c1c(cccc1)C(=O)[O-].[Na+].[Na+]

Uses

Fluorescein sodium (CAS NO.518-47-8) is used extensively as a diagnostic tool in the field of ophthalmology and optometry.

Toxicity Data With Reference

1.	dnd-esc 15 µmol/L	MUREAV Mutation Research. 89 (1981),95.
2.	ivn-man TDLo:14 mg/kg/10M-I:CVS AACRAT 66,283,87
3.	ivn-man TDLo:7142 µg/kg:EYE,GIT	AJOPAA American Journal of Ophthalmology. 103 (1987),111.
4.	orl-rat LD50:6721 mg/kg	JOPRAJ Journal of Periodontology. 48 (1977),228.
5.	orl-mus LD50:4738 mg/kg	JOPRAJ Journal of Periodontology. 48 (1977),228.
6.	ipr-mus LD50:1800 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 24 (1973),37.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Human systemic effects by intravenous route: arrhythmias, eye hemorrhage, nausea or vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Na₂O.
Hazard Codes: Irritant Xi
Risk Statements: 36-36/37/38
R36: Irritating to eyes
R36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25-37/39-26-36/37/39-27
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S37/39: Wear suitable gloves and eye/face protection
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S27: Take off immediately all contaminated clothing
WGK Germany: 1
RTECS: LM5425000
F 3: Hygroscopic
HS Code: 32041200

Specification

Handling and storge of Fluorescein sodium :
Handling: Wash thoroughly after handling. Use with adequate ventilation.Minimize dust generation and accumulation. Avoid ingestion and inhalation.Avoid contact with skin, eyes,and clothing. Keep container tightly closed.
Storage: Keep container closed when not in use. Store in a cool, dry,well-ventilated area away from incompatible substances. Store protected from moisture.
Fluorescein sodium (CAS NO.518-47-8) is also called as 9-(O-carboxyphenyl)-6-hydroxy-3h-xanthen-3-one,disodiumsalt ; 9’-(9H)xanthen)-3-one,3’,6’-dihydroxy-spiro(isobenzofuran-1(3hdisodiums) ; 9’-[9H]xanthen]-3-one,3’,6’-dihydroxy-spiro[isobenzofuran-1(3hdisodiumsal ; 9-O-carboxyphenyl-6-hydroxy-3 isoxanthone,disodiumsalt ; Abcoluraninepowders&liquids ; Aizenuranine .