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593-51-1

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Basic Information
CAS No.: 593-51-1
Name: Methylamine hydrochloride
Article Data: 100
Cas Database
Molecular Structure:
Molecular Structure of 593-51-1 (Methylamine hydrochloride)
Formula: CH6ClN
Molecular Weight: 67.5183
Synonyms: Methanamine,hydrochloride (9CI);Methanaminium chloride;Methylamine monohydrochloride;Methylammonium chloride;
EINECS: 209-795-0
Density: 0.8306 (rough estimate)
Melting Point: 231-233 °C(lit.)
Boiling Point: 38.2 °C at 760 mmHg
Flash Point: 225-230°C/15mm
Solubility: soluble in water
Appearance: white to light tan solid
Hazard Symbols: HarmfulXn
Risk Codes: 22-36/37/38
Safety: 26-37/39
Transport Information: N/A
PSA: 26.02000
LogP: 1.07720
Synthetic route
920-68-3

heptamethyldisilazane

A

107-46-0

Hexamethyldisiloxane

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchlorideA n/a
B 99%
39885-14-8

N-Nitroso-N-methylmethoxymethylamine

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol for 2h; Heating;97%
115584-91-3

(E)-2-Chloro-3-hydroxy-but-2-enoic acid methyl ester

109-89-7

diethylamine

A

593-51-1

methylamine hydrochloride

B

(E)-2-Chloro-3-hydroxy-but-2-enoic acid methyl ester; compound with diethyl-amine

Conditions
ConditionsYield
In diethyl ether at -40℃; for 1h;A n/a
B 96%
650-52-2

bis(trifluoromethyl)chlorophosphine

A

431-98-1

methylamino-bis-trifluoromethyl-phosphine

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With CH3NH2 In gaseous matrix 0°C;A 95%
B n/a
18197-25-6

N-formyl-N-methylformamide

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water for 168h; Ambient temperature;94%
593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
Stage #1: formamide With bis(tetrahydrofuran)calcium di(bis(trimethylsilyl)amide); 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 120℃; for 36h; Inert atmosphere; Schlenk technique;
Stage #2: With hydrogenchloride In diethyl ether; toluene Inert atmosphere; Schlenk technique;
90%
Stage #1: formamide With [(aNHC)KN(SiMe3)2]2; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane In toluene at 40℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique;
Stage #2: With water; sodium hydroxide In diethyl ether; toluene at 40℃; for 1h; Inert atmosphere; Glovebox; Schlenk technique;
Stage #3: With hydrogenchloride In diethyl ether; water Inert atmosphere; Glovebox; Schlenk technique;
98 %Spectr.
56-40-6

glycine

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
Stage #1: glycine With (R)-Carvone In propan-1-ol at 20 - 190℃; under 11251.1 Torr; for 0.216667h; Sealed tube; Microwave irradiation;
Stage #2: With hydrogenchloride In propan-1-ol; water at 190℃; for 0.0833333h; Microwave irradiation;
86%

C11H17N

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In propan-1-ol at 190℃; for 0.216667h; Temperature; Microwave irradiation; Green chemistry;86%

dichloro(nitrosyl)[tris(3,5-dimethylpyrazolyl)-borato]molybdenum

74-89-5

methylamine

A

Mo(HB(Me2pyz)3)(NO)Cl(NHMe)

B

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
In ethanol; dichloromethane under N2 soln. Mo(HB(Me2pyz)3)(NO)Cl2 in dichloromethane treated with methylamine (33% ethanolic soln.) and mixt. stirred at room temp. for 30 min; volume solvent reduced in vacuo, Et2O added, (NH3Me)Cl filtered off, filtrate reduced in vacuo; elem. anal.;A 83%
B n/a
75-52-5

nitromethane

593-51-1

methylamine hydrochloride

Conditions
ConditionsYield
Stage #1: nitromethane With hydrazine hydrate; zinc In methanol at 20℃; for 0.0666667h;
Stage #2: With hydrogenchloride
80%
With hydrogenchloride; zinc; hydrazinium monoformate In water for 0.0416667h;75%
Stage #1: nitromethane With formic acid; nickel In methanol at 20℃; for 0.0833333h; Reduction;
Stage #2: With hydrogenchloride Addition;
45%
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Specification

The IUPAC name of this chemical is Methanamine,hydrochloride. With the CAS registry number 593-51-1 and EINECS registry number 209-795-0, it is also named as methanaminium chloride. In addition, the molecular formula is CH6ClN. It is a kind of white to light tan solid and incompatible with strong oxidizing agents. And it may be sensitive with moisture. In addition, it can be used as a reagent for the analysis and used for organic synthesis.

Physical properties about Methylamine hydrochloride are:
(1)ACD/LogP: -0.66; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.76; (4)ACD/LogD (pH 7.4): -3.54; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)Enthalpy of Vaporization: 25.6 kJ/mol; (12)Boiling Point: 38.2 °C at 760 mmHg; (13)Vapour Pressure: 3970 mmHg at 25°C.

Preparation of Methylamine hydrochloride:
It can be prepared by carboamine solution. Add the hydrochloric acid into the carboamine solution. The pH value should be controlled at 2-3. And then after a series of decoloring, filtration, concentration and crystallization you can get the desired product. The equation is as follows:
Methanamine,hydrochloride (1:1) can be prepared by carboamine solution

Uses of Methylamine hydrochloride:
It can be used to get methylsulfamoyl chloride. This reaction will need reagent SO2Cl2, catalyst SbCl5 and solvent acetonitrile. The yield is about 66%.
Methanamine,hydrochloride (1:1) can be used to get methylsulfamoyl chloride

Safety information of Methylamine hydrochloride:
When you are using Methylamine hydrochloride, please be cautious about it as the following:This chemical is harmful if swallowed. It is irritating to eyes, respiratory system and skin. Whenever you will contact it, please wear gloves and eye/face protection. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: [Cl-].[NH3+]C
(2)InChI: InChI=1/CH5N.ClH/c1-2;/h2H2,1H3;1H
(3)InChIKey: NQMRYBIKMRVZLB-UHFFFAOYAJ

The toxicity data of Methylamine hydrochloride is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 skin > 2gm/kg (2000mg/kg)   Kodak Company Reports. Vol. 21MAY1971,
mouse LD50 intraperitoneal 2160mg/kg (2160mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.
rat LD50 oral 1600mg/kg (1600mg/kg)   Inhalation Toxicology. Vol. 2, Pg. 29, 1990.