CAS No.656247-17-5,Intedanib Suppliers

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Pharmaceutical (170)
Organic Chemicals (24)
Others (12)
Materials (3)
Reagent (3)
Basic Inorganic Chemicals (1)

Basic Information

Molecular Structure:
CAS No.:	656247-17-5
Name:	Intedanib
Article Data:	30
Cas Database

Formula:	C31H33N5O4
Molecular Weight:	539.634
Synonyms:	Vargatef;
EINECS:	1592732-453-0
Density:	1.284g/cm³
Melting Point:	N/A
Boiling Point:	742.199°C at 760 mmHg
Flash Point:	402.667°C
Solubility:	N/A
Appearance:	N/A
Hazard Symbols:	N/A
Risk Codes:	N/A
Safety:
Transport Information:	N/A
PSA:	94.22000
LogP:	3.70270

Related products

Synthetic route

: 656247-18-6
methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate ethanesulfonate salt

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; ethyl acetate at 40℃; for 1h;	98.7%
With sodium carbonate In water pH=9; Solvent; pH-value;	20 g

: 262368-30-9
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

: 1168152-07-5
(E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester With methanol In N,N-dimethyl-formamide at 75℃; for 4h; Large scale; Stage #2: With methanol; potassium hydroxide In N,N-dimethyl-formamide Temperature; Large scale;	94.6%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In methanol for 5h; Reflux; Stage #2: With potassium hydroxide In methanol at 20 - 70℃; for 0.5h; Concentration; Reagent/catalyst; Temperature; Solvent;	90%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In methanol; N,N-dimethyl-formamide Reflux; Stage #2: With piperidine In methanol; N,N-dimethyl-formamide Reflux;	88%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In methanol for 5h; Reflux; Stage #2: With potassium hydroxide In methanol	84%
Stage #1: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine; (E)-1-acetyl-3-(methoxy-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester In N,N-dimethyl-formamide at 80℃; for 1h; Stage #2: With piperidine In N,N-dimethyl-formamide at 20℃; for 2h;	77%

: 109-01-3
1-methyl-piperazine

: methyl 1-acetyl-3-(((4-(2-chloro-N-methylacetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 45 - 50℃;	93.74%

: 109-01-3
1-methyl-piperazine

: methyl-1-acetyl-3-((4-(2-chloro-N-ethylacetamido)phenyl)amino(phenyl)methylene)-2-oxoindoline-6-carboxylate

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 45 - 50℃;	93.74%

: 109-01-3
1-methyl-piperazine

: C26H22ClN3O4

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
In toluene at 65℃; for 4h; Solvent; Temperature;	93%

: 262368-30-9
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

: methyl 3-[bromo(phenyl)methylidene]-2-oxoindoline-6-formate

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol for 2h; Reflux;	92.7%

: 262368-30-9
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

: methyl 1-acetyl-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
With pyrrolidine In methanol at 25 - 50℃; for 6h;	91.37%

: 1-acetyl-3-(Z)-[1-(4-(N-((4-methylpiperazin-1-yl)methylcarbonyl)-N-methylaminophenyl)amino)-1-phenylmethylene]-6-methoxycarbonyl-2-indolinone

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
With methanol; potassium hydroxide at 20℃; Reagent/catalyst; Large scale;	91.3%
With methanol; potassium hydroxide at 50 - 55℃; for 2h; Temperature;

: 262368-30-9
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

: 1168150-46-6
(E)-methyl 3-(methoxy(phenyl)methylene)-2-indolone-6-carboxylic acid methyl ester

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
In methanol for 8h; Reflux;	90.8%

: 93-58-3
benzoic acid methyl ester

: 262368-30-9
N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine

: 14192-26-8
2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

: 656247-17-5
nintedanib

Conditions

Conditions	Yield
Stage #1: benzoic acid methyl ester; 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h; Stage #2: N-[(4-methyl-piperazin-1-yl)methylcarbonyl]-N-methyl-p-phenylendiamine In N,N-dimethyl-formamide at 20℃; for 4h;	89.7%

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