CAS No.66215-27-8,Cyromazine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	66215-27-8
Name:	Cyromazine
Article Data:	13
Cas Database

Formula:	C₆H₁₀N₆
Molecular Weight:	166.186
Synonyms:	1,3,5-Triazine-2,4,6-triamine,N-cyclopropyl- (9CI);2,4-Diamino-6-(cyclopropylamino)-s-triazine;2-Cyclopropylamino-4,6-diamino-s-triazine;CGA 72662;Citation;Cyclopropylmelamine;
EINECS:	266-257-8
Density:	1.622 g/cm³
Melting Point:	223-227 °C(lit.)
Boiling Point:	480.7 °C at 760 mmHg
Flash Point:	244.5 °C
Solubility:	13 g l-1 (pH 7.1,25 °C)
Appearance:	Colorless crystal
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
Transport Information:	N/A
PSA:	102.74000
LogP:	0.84570

Synthetic route

: 3397-62-4
2-Chloro-4,6-diamino-1,3,5-triazine

: 765-30-0
Cyclopropylamine

: 66215-27-8
cyromazine

Conditions

Conditions	Yield
With sodium hydroxide at 70 - 85℃; for 6h; pH=9.5; pH-value; Temperature;	96.37%
With potassium carbonate In water at 95 - 100℃; for 4h; pH=7.5 - 8.5; Temperature; Reagent/catalyst;	90.1%
With sodium hydroxide at -10 - 10℃; for 10h; Temperature;	24.47 g

: 32889-45-5
2,4-dichloro-6-cyclopropylamino-1,3,5-triazine

: 66215-27-8
cyromazine

Conditions

Conditions	Yield
With ammonia In water; toluene at 120℃; under 4500.45 Torr; for 10h;	93.5%

: 123-91-1
1,4-dioxane

: 35516-73-5
6-chloro-N-cyclopropyl-[1,3,5]triazine-2,4-diamine

: 66215-27-8
cyromazine

Conditions

Conditions	Yield
With ammonia
With ammonia

: 35516-73-5
6-chloro-N-cyclopropyl-[1,3,5]triazine-2,4-diamine

: 66215-27-8
cyromazine

Conditions

Conditions	Yield
With ammonia In 1,4-dioxane; water

: 66215-27-8
cyromazine

: 543-27-1
isobutyl chloroformate

: 2-cyclopropylamino-4,6-bis-isobutoxycarbonylamino-s-triazine

Conditions

Conditions	Yield
With pyridine; dmap In chloroform

: 75-36-5
acetyl chloride

: 66215-27-8
cyromazine

: 2,4-bis-acetylamino-6-cyclopropylamino-1,3,5-triazine

Conditions

Conditions	Yield
In pyridine

: 38870-89-2
Methoxyacetyl chloride

: 66215-27-8
cyromazine

: 2,4-bis-methoxyacetylamino-6-cyclopropylamino-1,3,5-triazine

Conditions

Conditions	Yield
In pyridine

: 66215-27-8
cyromazine

: 2-cyclopropylamino-4-acetylamino-6-amino-1,3,5-triazine

Conditions

Conditions	Yield
With acetic anhydride; triethylamine In tetrahydrofuran; diethyl ether

: 19500-95-9
Methoxyacetic anhydride

: 66215-27-8
cyromazine

: 99135-52-1
2-cyclopropylamino-4-methoxyacetylamino-6-amino-1,3,5-triazine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; diethyl ether

: 40244-90-4
Chlorodiisopropylphosphane

: 66215-27-8
cyromazine

: N-cyclopropyl-N,N-bis(diisopropylphosphaneyl)-1,3,5-triazine-2,4,6-triamine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 60℃; Inert atmosphere; Sealed tube;

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Chemistry

Molecular structure of Cyromazine (CAS NO.66215-27-8) is:

Product Name: Cyromazine
CAS Registry Number: 66215-27-8
IUPAC Name: 2-N-cyclopropyl-1,3,5-triazine-2,4,6-triamine
Molecular Weight: 166.1838 [g/mol]
Molecular Formula: C₆H₁₀N₆
XLogP3: -0.2
H-Bond Donor: 3
H-Bond Acceptor: 6
EINECS: 266-257-8
Melting Point: 223-227 °C(lit.)
Surface Tension: 132.7 dyne/cm
Density: 1.622 g/cm³
Flash Point: 244.5 °C
Enthalpy of Vaporization: 74.52 kJ/mol
Boiling Point: 480.7 °C at 760 mmHg
Vapour Pressure: 2.13E-09 mmHg at 25°C
Product Categories: Fine Chemical & Intermediates;Active Pharmaceutical Ingredients;Insecticide

Uses

In veterinary medicine, Cyromazine (CAS NO.66215-27-8) is used as a ectoparasiticide. Also it can be used as an insecticide and an acaricide.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
domestic animals - goat/sheep	LDLo	oral	500mg/kg (500mg/kg)	PERIPHERAL NERVE AND SENSATION: FASCICULATIONS BEHAVIORAL: ATAXIA	National Technical Information Service. Vol. OTS0538005,
duck	LD50	oral	> 6gm/kg (6000mg/kg)		Farm Chemicals Handbook. Vol. -, Pg. C91, 1991.
quail	LD50	oral	1785mg/kg (1785mg/kg)		Pesticide Manual. Vol. 9, Pg. 217, 1991.
rat	LC50	inhalation	> 2720mg/m³/4H (2720mg/m³)		Pesticide Manual. Vol. 9, Pg. 217, 1991.
rat	LD50	oral	3387mg/kg (3387mg/kg)		Pesticide Manual. Vol. 9, Pg. 217, 1991.
rat	LD50	skin	> 3100mg/kg (3100mg/kg)		Pesticide Manual. Vol. 9, Pg. 217, 1991.

Safety Profile

The Food Safety and Inspection Service (FSIS) of the United States Department of Agriculture (USDA) provides a test method for analyzing cyromazine and Melamine in animal tissues in its Chemistry Laboratory Guidebook which "contains test methods used by FSIS Laboratories to support the Agency's inspection program, ensuring that meat, poultry, and egg products are safe, wholesome and accurately labeled." In 1999, in a proposed rule published in the Federal Register regarding cyromazine residue, the United States Environmental Protection Agency (EPA) proposed "remov[ing] Melamine, a metabolite of cyromazine from the tolerance expression since it is no longer considered a residue of concern."
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 2
RTECS: XZ1056500

Specification

Cyromazine , its cas register number is 66215-27-8. It also can be called N-cyclopropyl-1,3,5-triazine-2,4,6-triamine ; 2-Cyclopropylamino-4,6-diamino-s-triazine ; Diamino-6-(cyclopropylamino)-s-triazine ; Cyclopropyl-1,3,5-triazine-2,4,6-triamine ; Cyclopropylmelamine ; Larvadex ; OMS-2014 ; Trigard .It is a crystals.It works by affecting the nervous system of the immature larval stages of certain insects.