CAS No.67-48-1,Choline chloride Suppliers

Products Categories

Pharmaceutical (219)
Others (108)
Food Additives (68)
Organic Chemicals (54)
Agrochemicals (49)
Materials (8)
Plant Extract (6)
(5)
Reagent (4)
Basic Inorganic Chemicals (4)
Catalyst and Auxiliary (3)
Adhesive and Sealant (1)

Basic Information

Molecular Structure:
CAS No.:	67-48-1
Name:	Choline chloride
Article Data:	39
Cas Database

Formula:	C₅H₁₄ClNO
Molecular Weight:	139.625
Synonyms:	Choline hydrochloride;Choline chloride solutions;(2-Hydroxyethyl)trimethylammonium chloride;Cholinum;Ethanaminium, 2-hydroxy-N,N, N-trimethyl-, chloride;Hormocline;Colina cloruro [DCIT];2-Hydroxy-N,N,N-trimethylethanaminium chloride;Ammonium, (2-hydroxyethyl)trimethyl-, chloride;2-Hydroxy-N,N,N-trimethylethanaminium;Cholinium chloride;sell choline chloride;Bilineurin chloride;Ethanaminium, 2-hydroxy-N,N,N-trimethyl-;Paresan;2-hydroxyethyl-trimethyl-azanium;Neocolina;Choline chlorhydrate;Lipotril;2-Hydroxy-N,N,N-trimethylammonium chloride;Choline, chloride;Chloride de choline [French];Chlorure de choline [INN-French];Biocolina;Cholini chloridum [INN-Latin];2-hydroxyethyl-trimethyl-azanium chloride;
EINECS:	200-655-4
Density:	1.205 g/cm3
Melting Point:	302-305 °C (dec.)(lit.)
Boiling Point:	N/A
Flash Point:	N/A
Solubility:	soluble in water
Appearance:	White crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
Transport Information:	N/A
PSA:	20.23000
LogP:	-3.31110

Synthetic route

: 75-21-8
oxirane

: 593-81-7
trimethylamine hydrochloride

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With sodium hydroxide at 24.9℃; Thermodynamic data; ΔrH1;	100%
With sodium hydroxide at 24.9℃;	100%

: 107-07-3
2-chloro-ethanol

: 75-50-3
trimethylamine

: 67-48-1
choline chloride

Conditions

Conditions	Yield
In methanol; acetonitrile at 70℃; for 14h; Inert atmosphere;	98%
at 80℃;
With water

: 64-17-5
ethanol

: C25H25Cl2N2O3(1+)*Cl(1-)

A: ethyl 3-amino-1-(2,4-dichlorophenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 9h;	A 88% B n/a

...Expand

: 64-17-5
ethanol

: C25H26BrN2O3(1+)*Cl(1-)

A: 330957-88-5
ethyl 3-amino-1-(4-bromo phenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 9h;	A 84% B n/a

...Expand

: 64-17-5
ethanol

: C25H26N3O5(1+)*Cl(1-)

A: 299937-04-5
ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A 83% B n/a

...Expand

: 64-17-5
ethanol

: C25H26N3O5(1+)*Cl(1-)

A: 330957-87-4
ethyl 3-amino-1-(4-nitro phenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A 74% B n/a

...Expand

: 64-17-5
ethanol

: C26H29N2O4(1+)*Cl(1-)

A: 67-48-1
choline chloride

B: 119825-14-8
ethyl 3-amino-1-(4-methoxyphenyl)-1H-benzo[f]chromene-2-carboxylate

Conditions

Conditions	Yield
With diethylamine at 40℃; for 11h;	A n/a B 73%

...Expand

: 64-17-5
ethanol

: C25H26ClN2O3(1+)*Cl(1-)

A: 67-48-1
choline chloride

B: 130944-14-8
ethyl 3-amino-1-(4-chlorophenyl)-1H-benzo[f]chromene-2-carboxylate

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A n/a B 70%

...Expand

: 64-17-5
ethanol

: C25H26N3O5(1+)*Cl(1-)

A: 405109-32-2
ethyl 3-amino-1-(2-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A 70% B n/a

...Expand

: 64-17-5
ethanol

: C26H26N3O3(1+)*Cl(1-)

A: 405109-16-2
C23H18N2O3

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 11h;	A 68% B n/a

...Expand

Raw Materials

64-17-5

7647-01-0

107-73-3

75-21-8

74-83-9

141-43-5

81372-19-2

593-81-7

Downstream Products

2932-74-3

104407-34-3

856676-23-8

71-36-3

75-50-3

71-27-2

2964-09-2

816-94-4

Total:319 Page 1 of 9 1 2 3 4 5 6 …9 Next>>

Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields

Chemistry

Structure of Choline chloride (CAS NO.67-48-1):

IUPAC Name: 2-hydroxyethyl(trimethyl)azanium chloride
Empirical Formula: C₅H₁₄ClNO
Molecular Weight: 139.6238
EINECS: 200-655-4
Melting point: 298-304 ºC
Water solubility: soluble
Sensitive: Hygroscopic
Physical Appearance: White crystalline powder
Product Categories: Quarternary ammonium salts;Ammonium Chlorides (Quaternary);Biochemistry;Quaternary Ammonium Compounds;Vitamin Related Compounds;Vitamins;Antioxidants;Intermediates & Fine Chemicals;Pharmaceuticals
Synonyms of Choline chloride (CAS NO.67-48-1): (2-Hydroxyethyl)trimethylammonium chloride ; (beta-Hydroxyethyl)trimethylammonium chloride ; 2-Hydroxy-N,N,N,-trimethylethanaminium chloride ; Ammonium, (2-hydroxyethyl)trimethyl-, chloride ; Bilineurin chloride ; Biocolina ; Biocoline ; Chloride de choline ; Choline chlorhydrate ; Choline hydrochloride ;
Cholini chloridum ; Cloruro de colina ; Colina cloruro ; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride ; Hepacholine ;
Hormocline ; Lipotril ; Luridin chloride ; Trimethyl(2-hydroxyethyl)ammonium chloride .

Uses

Choline chloride (CAS NO.67-48-1) is an important additive in feed especially for chicken where it accelerates growth and is mass produced . With urea it forms a deep eutectic solvent. Other commercial choline salts are choline bitartrate choline and hydroxide . In foodstuffs the compound is often present as phosphatidylcholine.

Production

In the industrial Davy process choline chloride is produced from ethylene oxide, hydrochloric acid, and trimethylamine,[1] or from the pre-formed salt:

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	25mg/kg (25mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog	LDLo	intravenous	5mg/kg (5mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog	LDLo	unreported	1500mg/kg (1500mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse	LD50	intraperitoneal	320mg/kg (320mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse	LD50	intravenous	53mg/kg (53mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse	LD50	oral	3900mg/kg (3900mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse	LDLo	subcutaneous	735mg/kg (735mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 6, Pg. 477, 1914/1915.
rabbit	LDLo	intraperitoneal	500mg/kg (500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.
rabbit	LDLo	intravenous	1100ug/kg (1.1mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit	LDLo	rectal	1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit	LDLo	subcutaneous	1gm/kg (1000mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rat	LD50	intraperitoneal	450mg/kg (450mg/kg)		Indian Journal of Experimental Biology. Vol. 24, Pg. 91, 1986.
rat	LD50	oral	3400mg/kg (3400mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Proceedings of the Society for Experimental Biology and Medicine. Vol. 58, Pg. 87, 1945.

Safety Profile

Hazard Codes: Xi
The Risk Statements information of Choline chloride :
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of Choline chloride :
26: In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 1
RTECS: KH2975000
F: 3-9