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| CAS No.: | 70288-86-7 |
|---|---|
| Name: | Ivermectin |
| Molecular Structure: | |
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| Formula: | Unspecified |
| Molecular Weight: | 875.09300 |
| Synonyms: | Ivermectin EP6; |
| EINECS: | 274-536-0 |
| Density: | N/A |
| Melting Point: | N/A |
| Boiling Point: | N/A |
| Flash Point: | N/A |
| Solubility: | 4mg/L(temperature not stated) |
| Appearance: | White crystalline powder |
| Hazard Symbols: | T,Xn,T+ |
| Risk Codes: | T,Xn |
| Safety: | 53-26-45-36-36/37-28 |
| Transport Information: | N/A |
| PSA: | 170.06000 |
| LogP: | 5.60140 |
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Ivermectin (22,23-dihydroavermectin B1a + 22,23-dihydroavermectin B1b) is a broad-spectrum antiparasitic medication. Ivermectin is a mixture of two compounds 22,23-dihydroavermectin B1a and 22,23-dihydroavermectin B1b, which differ by a single ethyl or methyl side group.
It is traditionally used against worms, but more recently found to be effective against mites and some lice too.
Mectizan is currently being used to help eliminate river blindness (onchocerciasis) in the Americas and stop transmission of lymphatic filariasis around the world. Currently, large amounts of Mectizan are donated by Merck to fight river blindness in countries that are unable to afford the drug.
scu-ctl LDLo:8 mg/kg SCIEAS Science. 221 (1983),823.
The main concern is neurotoxicity, which in most mammalian species may manifest as CNS depression, and consequent ataxia, as might be expected from potentiation of inhibitory GABA-ergic synapses.
Poison by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.
