CAS No.7531-52-4,L-Prolinamide Suppliers

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Basic Information

Molecular Structure:
CAS No.:	7531-52-4
Name:	L-Prolinamide
Article Data:	43
Cas Database

Formula:	C₅H₁₀N₂O
Molecular Weight:	114.147
Synonyms:	Prolinamide;(2S)-pyrrolidine-2-carboxamide;H-Pro-NH2;(2S)-2,3,4,5-tetrahydropyrrole-2-carboxamide;(S)-Prolinamide;Pro-NH2;Pro- NH2;L-Prolinmide;
EINECS:	231-397-0
Density:	1.106 g/cm³
Melting Point:	97-102 °C
Boiling Point:	303.6 °C at 760 mmHg
Flash Point:	137.4 °C
Solubility:	Soluble in water and ethanol (50 mg/ml).
Appearance:	white crystalline powder
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38
Safety:	22-24/25-36/37/39-26
Transport Information:	N/A
PSA:	55.12000
LogP:	0.25280

Synthetic route

: 34079-31-7
Z-Pro-NH2

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With 10% palladium on carbon; hydrogen In methanol for 7h;	100%
With hydrogen; palladium on activated charcoal In methanol for 9h; Ambient temperature;	88.4%
With hydrogen; palladium on activated charcoal In methanol under 2068.6 Torr; for 5h;	87%
With hydrogen; palladium In methanol for 3h;

: 16395-58-7
N-acetyl-L-prolinamide

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With hydrogenchloride In water at 103℃; for 2h; Temperature;	95.3%

: 2133-40-6
L-proline methyl ester monohydrochloride

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With ammonia In methanol	91%
With ammonia In methanol at 0 - 20℃; for 15h; Reagent/catalyst; Large scale;	85%
With ammonia In methanol at -25℃; for 96h; Sealed tube;	55%

: 2577-48-2
methyl (2S)-pyrrolidine carboxylate

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With ammonia In methanol at 65℃; for 15h;	90%
With methanol; ammonia
With ammonium hydroxide
With ammonium hydroxide In butan-1-ol at 5 - 30℃;

: 929897-95-0
(2S,1'S)-1-(1'-phenylethyl)pyrrolidine-2-carboxamide

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With hydrogen; palladium dihydroxide In ethanol; ethyl acetate at 20℃; under 760 Torr; for 14h;	77%

: 115134-39-9
(S)-(9H-fluoren-9-yl)methyl 2-carbamoylpyrrolidine-1-carboxylate

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With morpholine In N,N-dimethyl-formamide for 1h;	73%
With alkylamine In N,N-dimethyl-formamide at 20℃; for 1h;

: 147-85-3
L-proline

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Stage #1: L-proline With thionyl chloride In methanol for 2h; Heating; Stage #2: With ammonia In methanol at 20℃; for 96h; Further stages.;	72%
Multi-step reaction with 3 steps 1: sodium hydroxide / H2O / Ambient temperature 2: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight 3: 88.4 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature View Scheme
Multi-step reaction with 2 steps 1: thionyl chloride / -5 - 70 °C 2: ammonium hydroxide / butan-1-ol / 5 - 30 °C View Scheme

: 6422-36-2
L-prolyl-L-alanine

A: (2R,5S)-2-Methyl-1,3-diazabicyclo<3.3.0>octan-4-on

B: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With ammonium acetate anodic oxidation; Pt electrodes, i = 370 mA*cm-2, current equiv.: 6.2 F/mol;	A 49% B 41%

: 5817-26-5
ethyl (2S)-pyrrolidine-2-carboxylate

: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
With methanol; ammonia

: 125219-05-8
(S)-2-Carbamoyl-pyrrolidine-1-carboxylic acid 2-(4-methoxy-phenyl)-2-oxo-ethyl ester

A: 100-06-1
1-(4-methoxyphenyl)ethanone

B: 7531-52-4
L-prolinamide

Conditions

Conditions	Yield
Irradiation; mild conditions;

Raw Materials

147-85-3

Downstream Products

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Chemistry

IUPAC Name of L-Prolinamide (CAS NO.7531-52-4): pyrrolidine-2-carboxamide
Molecular Formula: C₅H₁₀N₂O
Molecular Weight: 114.15 g/mol
Following is the molecular structure of L-Prolinamide (CAS NO.7531-52-4):

BRN: 80807
EINECS: 231-397-0
Density: 1.106 g/cm³
Flash Point: 137.4 °C
Index of Refraction: 1.491
Melting Point: 95-97 °C(lit.)
Surface Tension: 41.4 dyne/cm
Solubility in water: Very soluble
Enthalpy of Vaporization: 54.39 kJ/mol
Boiling Point: 303.6 °C at 760 mmHg
Vapour Pressure: 0.000923 mmHg at 25 °C
Appearance: white to off-white microcrystalline powder
Product Categories: Aminoacids Derivatives;APIs;Amino Acids;Proline [Pro, P];Amino Acids and Derivatives;Amides (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Amino Acid Derivatives;Peptide Synthesis;Proline

Toxicity Data With Reference

L-Prolinamide (CAS NO.7531-52-4) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated.

Safety Profile

Safty informations about L-Prolinamide (7531-52-4):
Hazard Codes: Harmful Xn ( Harmful)
Risk Statements: 22-36/37/38
R22:Harmful if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements: 22-24/25
S22:Do not breathe dust
S24/25:Avoid contact with skin and eyes
WGK Germany: 3

Specification

L-Prolinamide , its cas register number is 7531-52-4. It also can be called Proline-nh2 ; Prolinamide ; (s)-Pyrrolidine-2-carboxylic acid amide ; (s)-Prolinamide ; H-Pro-nh2 ; L-Proline amide ; L-(-)-Prolinamide;l-prolinamide .
L-Prolinamide (CAS NO.7531-52-4) is stable under normal temperatures and pressures. L-Prolinamide (CAS NO.7531-52-4) should avoid the condition like incompatible materials. It is incompatible with other materials strong oxidizing agents. Its hazardous decomposition products are nitrogen oxides, carbon monoxide, carbon dioxide. Its hazardous polymerization has not been reported.