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Cas Database

430-99-9

430-99-9

Identification

  • Molecular Formula:C3H3FO2

  • EINECS:

Synonyms:Acrylicacid, 2-fluoro- (8CI);2-Fluoroacrylic acid;

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Safety information and MSDS

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:

  • Hazard Statement:

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:AK Scientific
  • Product Description:2-Fluoroacrylicacid
  • Packaging:1g
  • Price:$ 61
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:2-Fluoroacrylicacid
  • Packaging:5g
  • Price:$ 194
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  • Manufacture/Brand:AK Scientific
  • Product Description:2-Fluoroacrylicacid
  • Packaging:25g
  • Price:$ 620
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  • Manufacture/Brand:AK Scientific
  • Product Description:2-Fluoroacrylicacid
  • Packaging:25g
  • Price:$ 827
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  • Manufacture/Brand:AK Scientific
  • Product Description:2-Fluoroacrylicacid
  • Packaging:4x25g
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  • Manufacture/Brand:AK Scientific
  • Product Description:2-Fluoroacrylicacid
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  • Manufacture/Brand:Ambeed
  • Product Description:2-Fluoroacrylicacid 98%
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  • Manufacture/Brand:Ambeed
  • Product Description:2-Fluoroacrylicacid 98%
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  • Manufacture/Brand:Ambeed
  • Product Description:2-Fluoroacrylicacid 98%
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  • Manufacture/Brand:Ambeed
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Relevant articles and documentsAll total 4 Articles be found

SYNTHESIS OF 2-FLUOROPROPENOIC ACID DERIVATIVES

Tolman, Vladimir,Spronglova, Pavla

, p. 319 - 326 (2007/10/02)

A method is described for the synthesis of 2-fluoropropenoic acid esters, amides, and nitrile from the corresponding derivatives of 2-fluoro-3-(4-toluenesulfonyloxy)propanoic acid by heating with potassium phtalimide in vacuo.The free acid Ia and its chloride have also been synthetized.The reactivity of esters and nitrile of acid Ia has been verified by the Michael addition of diethyl acetamidomalonate to these compounds.

PRODUCTION METHOD FOR ALPHA-FLUORO ACRYLIC ACID ESTERS

-

Paragraph 0149; 0150, (2016/11/17)

An object of the present invention is to provide a process for producing α-fluoroacrylic acid esters at a high starting material conversion and a high yield. The present invention provides, as a means to achieve the object, a process for producing a compound represented by formula (1): wherein R2 and R2 are the same or different and each represent alkyl, fluoroalkyl, aryl optionally substituted with at least one substituent, halogen, or hydrogen; and R3 represents alkyl, fluoroalkyl, or aryl optionally substituted with at least one substituent, the process comprising step A ofreacting a compound represented by formula (2): wherein the symbols are as defined above, with carbon monoxide and an alcohol represented by formula (3): [in-line-formulae]R3—OH ??(3)[/in-line-formulae]wherein the symbol is as defined above, in the presence of a transition metal complex catalyst containing at least one bidentate phosphine ligand and a base to thereby obtain the compound represented by formula (1).

METHOD FOR PRODUCING alpha-FLUOROACRYLIC ACID

-

Paragraph 0307-0308; 0313-0314; 0326-0327, (2021/09/03)

An object of the present invention is to provide a novel method for producing an α-fluoroacrylic acid ester compound. This problem is solved by a method for producing a compound represented by formula (1), wherein R1 and R2 are identical or different, and each represents an alkyl group or the like; and R3 is an alkyl group or the like, the method comprising step A of reacting a compound represented by formula (2) with R3—OH (3) and carbon monoxide in the presence of palladium, a double bond-containing compound (α), a diphosphine compound (β), and a base, to obtain the compound represented by formula (1) above.

Low-temperature 19F NMR spectroscopy of 1-fluoro-1-lithioethenes - Stability, shifts and unexpected coupling constants

Kvicala, Jaroslav,Hrabal, Richard,Czernek, Jiri,Bartosova, Ivana,Paleta, Oldrich,Pelter, Andrew

, p. 211 - 218 (2007/10/03)

Half-lives and fluorine atom shifts of stabilized 1-fluoro-l-lithioethenes bearing hydrogen, fluorine, phenyl, and/or dimethylphenylsilyl groups in the β-positions have been determined by a low-temperature 19F NMR spectroscopy. Some 1-fluoro-1-lithioethenes displayed an exceptionally low value of the trans-3JFF coupling constant. Stereoselectivity of carbenoid formation, as well as an effect of configuration on the stability is discussed.

Process route upstream and downstream products

Process route

ethyl 2-fluoroacrylate
760-80-5

ethyl 2-fluoroacrylate

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

Conditions
ConditionsYield
39%
Withsodium hydroxide; at 20 ℃;
0.30 g
methanol
67-56-1

methanol

1-bromo-1-fluoroethylene
420-25-7

1-bromo-1-fluoroethylene

carbon monoxide
201230-82-2

carbon monoxide

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
Withdichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll); triethylamine; at 100 ℃; for 13h; under 7500.75 Torr; Autoclave;
70.9%
14.1%
methanol
67-56-1

methanol

1-chloro-1-fluoroethane
2317-91-1

1-chloro-1-fluoroethane

carbon monoxide
201230-82-2

carbon monoxide

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
With1,4-bis(dicyclohexylphosphino)butane; palladium(II) acetylacetonate; triethylamine; at 85 ℃; for 26h; Temperature; Autoclave;
2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

(S)-(4-(4-amino-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)(phenyl)methanone

(S)-(4-(4-amino-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)(phenyl)methanone

(R)-1-(3-(4-amino-5-(4-benzoylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidin-1-yl)-2-fluoropropene-1-one

(R)-1-(3-(4-amino-5-(4-benzoylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidin-1-yl)-2-fluoropropene-1-one

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

2-((S)-4-(8-benzyl-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-c]azepin-4-yl)piperazin-2-yl)acetonitrile

2-((S)-4-(8-benzyl-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-c]azepin-4-yl)piperazin-2-yl)acetonitrile

2-((S)-4-(8-benzyl-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-c]azepin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile

2-((S)-4-(8-benzyl-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-7-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-c]azepin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

2-((S)-4-(8-benzyl-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-9-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-c]azepin-4-yl)piperazin-2-yl)acetonitrile dihydrochloride

2-((S)-4-(8-benzyl-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-9-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-c]azepin-4-yl)piperazin-2-yl)acetonitrile dihydrochloride

2-((S)-4-(8-benzyl-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-9-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-c]azepin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile

2-((S)-4-(8-benzyl-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-9-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-c]azepin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile

3-(benzyloxy)azetidine hydrochloride
897019-59-9

3-(benzyloxy)azetidine hydrochloride

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

1-(3-(benzyloxy)azetidin-1-yl)-2-fluoroprop-2-en-1-one

1-(3-(benzyloxy)azetidin-1-yl)-2-fluoroprop-2-en-1-one

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

2-(4-hydroxyphenyl)-2-propanol
2948-47-2

2-(4-hydroxyphenyl)-2-propanol

C<sub>12</sub>H<sub>13</sub>FO<sub>3</sub>

C12H13FO3

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

(R)-3-(4-phenoxyphenyl)-1-(tetrahydropyrrole-2-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-3-(4-phenoxyphenyl)-1-(tetrahydropyrrole-2-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

(R)-1-(2-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)tetrahydropyrrole-1-yl)-2-fluoropropen-1-one

(R)-1-(2-((4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)tetrahydropyrrole-1-yl)-2-fluoropropen-1-one

methanol
67-56-1

methanol

2-fluoroacrylic acid
430-99-9

2-fluoroacrylic acid

methyl 2-fluoroprop-2-enoate
2343-89-7

methyl 2-fluoroprop-2-enoate

Conditions
ConditionsYield
Withthionyl chloride; at 5 - 35 ℃; for 2h; Concentration; Reagent/catalyst;
93%

Global suppliers and manufacturers

Global( 58) Suppliers
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  • Amadis Chemical Co., Ltd.
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  • Shaanxi BLOOM TECH Co.,Ltd
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  • Kono Chem Co.,Ltd
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  • Emails:info@konochemical.com
  • Main Products:87
  • Country:China (Mainland)
  • Finetech Industry Limited
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