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Cas Database

437-82-1

437-82-1

Identification

  • Molecular Formula:C7H6F2O

  • EINECS:

Synonyms:1,3-difluoro-2-methoxybenzene;

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Safety information and MSDS

  • Pictogram(s):IrritantXi, FlammableF

  • Hazard Codes:Xi,F

  • Signal Word:

  • Hazard Statement:

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:AHH
  • Product Description:2,6-Difluoroanisole 98%
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  • Manufacture/Brand:AK Scientific
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  • Manufacture/Brand:Alfa Aesar
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  • Manufacture/Brand:Alfa Aesar
  • Product Description:2,6-Difluoroanisole, 98+%
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  • Manufacture/Brand:Alichem
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  • Manufacture/Brand:Alichem
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  • Manufacture/Brand:Alichem
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  • Manufacture/Brand:Ambeed
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Relevant articles and documentsAll total 7 Articles be found

Quinolonecarboxylic acid derivatives or salts thereof

-

, (2008/06/13)

PCT No. PCT/JP97/00317 Sec. 371 Date Aug. 10, 1998 Sec. 102(e) Date Aug. 10, 1998 PCT Filed Feb. 7, 1997 PCT Pub. No. WO97/29102 PCT Pub. Date Aug. 14, 1997The present invention relates to a quinolone-carboxylic acid derivative represented by the general

Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1)

El-Ayache, Nadine C.,Li, Shih-Hon,Warnock, Mark,Lawrence, Daniel A.,Emal, Cory D.

supporting information; experimental part, p. 966 - 970 (2010/06/16)

Inactivators of plasminogen activator inhibitor-1 (PAI-1) have been identified as possible treatments for a range of conditions, including atherosclerosis, venous thrombosis, and obesity. We describe the synthesis and inhibitory activity of a novel series

HETEROCYCLICALLY SUBSTITUTED PENTANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS

-

Page/Page column 45-50, (2010/02/10)

The invention relates to pentanol derivatives of general formula (I), which are substituted by quinazoline, quinoxaline, cinnoline, indazole, phthalazine, naphthyridine, benzothiazole, dihydroindolone, dihydroisoindolone, benzimidazole, or indole, a method for the production thereof, and the use thereof as anti-inflammatory agents.

1-cyclopropyl-4-oxo-7-fluoro-8-methoxy -1,4-dihydro-quinoline-3-carboxylic acid synthesizing method

-

, (2017/01/26)

The invention discloses a synthesis method of 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method comprises the following reaction steps: reacting m-difluorophenyl with an organolithium reagent, reacting an obtained aryllithium intermediate with borate, quenching to obtain 2,6-difluorophenylboronic acid and 2,6-difluorophenylborate, reacting 2,6-difluorophenol obtained through oxidation with a methylating reagent, reacting the obtained 2,6-difluorophenylmethyl ether with the organolithium reagent, reacting the obtained corresponding aryllithium intermediate with carbon dioxide, reacting the obtained product with an acylchlorinating reagent to obtain 2,4-difluoro-3-methoxy benzoyl chloride, and performing cyclization, hydrolysis and the like to obtain the 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method has the advantages as follows: raw materials are easy to obtain; the yield in each step is high; the atom economy is high; the synthesis method is suitable for industrial application.

1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS

-

Page/Page column 59, (2010/02/11)

The invention relates to polysubstituted tetrahydronaphtalene derivatives of formula (I), to methods for the production thereof, and to their use as antiphlogistics. The substituents are defined in Claim 1.

Process route upstream and downstream products

Process route

3-fluoro-2-methoxyaniline
437-83-2

3-fluoro-2-methoxyaniline

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

Conditions
ConditionsYield
Withhydrogenchloride;Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck;
2,6-difluorophenol
28177-48-2

2,6-difluorophenol

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

Conditions
ConditionsYield
Indiethyl ether;at 0 - 20 ℃;
95%
1,2,3-trifluorobenzene
1489-53-8

1,2,3-trifluorobenzene

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

2.3-difluoroanisole
134364-69-5

2.3-difluoroanisole

Conditions
ConditionsYield
Withsodium methylate;Inmethanol; dimethyl sulfoxide;at 25.1 ℃; Rate constant; methoxydefluorination;
2,6-difluorophenol
28177-48-2

2,6-difluorophenol

methyl iodide
74-88-4

methyl iodide

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

Conditions
ConditionsYield
potassium carbonate;Inacetone;for 3.5h; Heating / reflux;
77.9%
Withpotassium carbonate;Inacetone;for 3.5h; Heating / reflux;
77.9%
Withpotassium carbonate;InN,N-dimethyl-formamide;at 50 ℃; Inert atmosphere;
65%
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: propyllithium / hexane; ethylbenzene / 1 h / -50 °C / Inert atmosphere
1.2: 4 h / -60 - -30 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / water; 2-methyltetrahydrofuran / 10 h / 40 - 50 °C
Multi-step reaction with 3 steps
1.1: n-butyllithium / diethyl ether; hexane / 2 h / -70 - -60 °C / Inert atmosphere
1.2: 2 h / -60 - -50 °C / Inert atmosphere
2.1: peracetic acid / tetrahydrofuran; water / 20 h / 20 - 30 °C
3.1: sodium hydrogencarbonate / water; 2-methyltetrahydrofuran / 10 h / 40 - 50 °C
1,3-Difluorobenzene
372-18-9

1,3-Difluorobenzene

methyl iodide
74-88-4

methyl iodide

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

Conditions
ConditionsYield
1,3-Difluorobenzene;Withpropyllithium;Inhexane; toluene;at -50 ℃; for 1h; Inert atmosphere;
Withboric acid tributyl ester; at -50 - -30 ℃; for 6h;
8.5 g
2,6-difluorophenylboronic acid
162101-25-9

2,6-difluorophenylboronic acid

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: peracetic acid / tetrahydrofuran; water / 20 h / 20 - 30 °C
2: sodium hydrogencarbonate / water; 2-methyltetrahydrofuran / 10 h / 40 - 50 °C
2,6-difluorophenol
28177-48-2

2,6-difluorophenol

dimethyl sulfate
77-78-1

dimethyl sulfate

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

Conditions
ConditionsYield
Withsodium hydrogencarbonate;In2-methyltetrahydrofuran; water;at 40 - 50 ℃; for 10h; Temperature; Reagent/catalyst; Solvent;
27.5 g
1-fluoro-2-methoxy-3-nitrobenzene
484-94-6

1-fluoro-2-methoxy-3-nitrobenzene

1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: platinum / Hydrogenation
2: concentrated aqueous HCl / Diazotization.anschliessende Behandlung mit NaBF4 und Erhitzen des erhaltenen Diazonium-tetrafluoroborats unter vermindertem Druck
1,3-difluoro-2-methoxybenzene
437-82-1

1,3-difluoro-2-methoxybenzene

2,6-difluorophenoxyacetic acid
363-45-1

2,6-difluorophenoxyacetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous hydrochloric acid / 200 °C
2: aq. NaOH solution

Global suppliers and manufacturers

Global( 86) Suppliers
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  • Simagchem Corporation
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  • Amadis Chemical Co., Ltd.
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  • Afine Chemicals Limited
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  • Emails:info@afinechem.com
  • Main Products:92
  • Country:China (Mainland)
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