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Cas Database

440122-66-7

440122-66-7

Identification

  • Molecular Formula:C13H8BrNO3

  • EINECS:

Synonyms:7-Bromo-2-(4-hydroxy-phenyl)-benzooxazol-5-ol;5-Benzoxazolol,7-bromo-2-(4-hydroxyphenyl);7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol;7-BROMO-2-(4-HYDROXYPHENYL)-1,3-BENZOXAZOL-5-OL;7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol;

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Safety information and MSDS

  • Pictogram(s):

  • Hazard Codes:T

  • Signal Word:

  • Hazard Statement:

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:WAY 200070
  • Packaging:10mg
  • Price:$ 409
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:WAY200070
  • Packaging:5mg
  • Price:$ 185
  • Delivery:In stock
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  • Manufacture/Brand:Tocris
  • Product Description:WAY200070 ≥98%(HPLC)
  • Packaging:50
  • Price:$ 710
  • Delivery:In stock
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  • Manufacture/Brand:Tocris
  • Product Description:WAY200070 ≥98%(HPLC)
  • Packaging:10
  • Price:$ 170
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:WAY-200070 ≥98% (HPLC)
  • Packaging:5mg
  • Price:$ 120
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:WAY-200070 ≥98% (HPLC)
  • Packaging:25mg
  • Price:$ 461
  • Delivery:In stock
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  • Manufacture/Brand:DC Chemicals
  • Product Description:WAY-200070 >98%
  • Packaging:1 g
  • Price:$ 1100
  • Delivery:In stock
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  • Manufacture/Brand:DC Chemicals
  • Product Description:WAY-200070 >98%
  • Packaging:250 mg
  • Price:$ 550
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:7-Bromo-2-(4-hydroxyphenyl)benzo[d]oxazol-5-ol 97%
  • Packaging:100mg
  • Price:$ 691
  • Delivery:In stock
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  • Manufacture/Brand:Cayman Chemical
  • Product Description:WAY-200070 ≥98%
  • Packaging:25mg
  • Price:$ 268
  • Delivery:In stock
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Relevant articles and documentsAll total 2 Articles be found

Substituted benzoxazoles as estrogenic agents

-

, (2008/06/13)

This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.

Prodrug substituted benzoxazoles as estrogenic agents

-

Page/Page column 28, (2010/10/20)

This invention provides estrogen receptor modulators of formula I, having the structure wherein Q, Q2, R1, R2, R2a, R3, R3a, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.

Process route upstream and downstream products

Process route

7-bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole
440123-20-6

7-bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole

WAY 200070
440122-66-7

WAY 200070

Conditions
ConditionsYield
Withwater;Inmethanol; diethyl ether; dichloromethane;at 0 ℃; Product distribution / selectivity;
92%
Withwater;Indichloromethane;Product distribution / selectivity;
86%
methanol
67-56-1

methanol

7-bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole
440123-20-6

7-bromo-5-methoxy-2-(4-methoxyphenyl)-1,3-benzoxazole

WAY 200070
440122-66-7

WAY 200070

WAY 200070
440122-66-7

WAY 200070

WAY-292

WAY-292

Conditions
ConditionsYield
20 mg (25%)
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

WAY 200070
440122-66-7

WAY 200070

7-bromo-5-{[tert-butyl(dimethyl)silyl]oxy}-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1,3-benzoxazole
544705-04-6

7-bromo-5-{[tert-butyl(dimethyl)silyl]oxy}-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1,3-benzoxazole

Conditions
ConditionsYield
96%
WAY 200070
440122-66-7

WAY 200070

ethyl 5-hydroxy-2-(4-hydroxyphenyl)-1,3-benzoxazole-7-carboxylate

ethyl 5-hydroxy-2-(4-hydroxyphenyl)-1,3-benzoxazole-7-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: 96 percent / imidazole; N,N-dimethylpyridin-4-amine / dimethylformamide / 3 h
2.1: n-BuLi / tetrahydrofuran / 2 h / 40 °C
2.2: 340 mg / tetrahydrofuran / 1 h / 0 °C
3.1: 53 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h
WAY 200070
440122-66-7

WAY 200070

ethyl 5-{[tert-butyl(dimethyl)silyl]oxy}-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1,3-benzoxazole-7-carboxylate

ethyl 5-{[tert-butyl(dimethyl)silyl]oxy}-2-(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)-1,3-benzoxazole-7-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 96 percent / imidazole; N,N-dimethylpyridin-4-amine / dimethylformamide / 3 h
2.1: n-BuLi / tetrahydrofuran / 2 h / 40 °C
2.2: 340 mg / tetrahydrofuran / 1 h / 0 °C
sodium methylate
124-41-4

sodium methylate

WAY 200070
440122-66-7

WAY 200070

2-(4-hydroxyphenyl)-7-methoxy-1,3-benzoxazol-5-ol
544705-07-9

2-(4-hydroxyphenyl)-7-methoxy-1,3-benzoxazol-5-ol

Conditions
ConditionsYield
60%

Global suppliers and manufacturers

Global( 10) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Hubei Vanz Pharm Co.,Ltd
  • Business Type:Trading Company
  • Contact Tel:86-27-84492310
  • Emails:sales08@vanzpharm.com
  • Main Products:90
  • Country:China (Mainland)
  • Boc Sciences
  • Business Type:Trading Company
  • Contact Tel:1-631-485-4226
  • Emails:sales@bocsci.com
  • Main Products:41
  • Country:United States
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