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Cas Database

445-14-7

445-14-7

Identification

  • Molecular Formula:C7H5ClF3N

  • EINECS:207-153-4

Synonyms:o-Toluidine,5-chloro-a,a,a-trifluoro- (6CI,7CI,8CI);2-(Trifluoromethyl)-5-chloroaniline;5-Chloro-2-trifluoromethylaniline;

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Safety information and MSDS

  • Pictogram(s):HarmfulXn

  • Hazard Codes:Xn

  • Signal Word:

  • Hazard Statement:

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:AHH
  • Product Description:2-AMINO-4-CHLOROBENZOTRIFLUORIDE 97%
  • Packaging:1g
  • Price:$ 125
  • Delivery:In stock
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  • Manufacture/Brand:AK Scientific
  • Product Description:2-Amino-4-chlorobenzotrifluoride
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  • Product Description:2-Amino-4-chlorobenzotrifluoride 98%
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  • Manufacture/Brand:Ambeed
  • Product Description:2-Amino-4-chlorobenzotrifluoride 98%
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  • Product Description:2-Amino-4-chlorobenzotrifluoride 98%
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-AMINO-4-CHLOROBENZOTRIFLUORIDE 95.00%
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:2-AMINO-4-CHLOROBENZOTRIFLUORIDE 95.00%
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  • Manufacture/Brand:Apolloscientific
  • Product Description:5-Chloro-2-(trifluoromethyl)aniline 95%
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  • Manufacture/Brand:Apolloscientific
  • Product Description:5-Chloro-2-(trifluoromethyl)aniline 95%
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Relevant articles and documentsAll total 3 Articles be found

Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors

Tordeux, Marc,Langlois, Bernard,Wakselman, Claude

, p. 2293 - 2299 (2007/10/02)

Perfluoroalkylation of electron-rich aromatic compounds with trifluoromethyl bromide, or long-chain perfluoroalkyl iodides, was performed in the presence of sodium dithionite or zinc-sulphur dioxide.This alkylation occurred at the ortho and para positions relative to the amino or hydroxy substitutent.Pyrroles were perfluoroalkylated regioselectively at the 2-position.This alkylation was interpreted as a radical aromatic substitution; the formation of the perfluoroalkyl radical can be induced by a single-electron transfer from sulphur dioxide radical anion to the perfluoroalkyl halide.

Deoxofluorination of (Hetero)aromatic Acids

Alekseenko, Anatoliy N.,Bugera, Maksym Ya.,Gerus, Igor I.,Kiriakov, Oleksandr,Klipkov, Anton A.,Mykhailiuk, Pavel K.,Pustovit, Yurii,Razhyk, Bohdan,Semenov, Sergey,Starova, Viktoriia S.,Tananaiko, Oksana Yu.,Tarasenko, Karen,Tolmachev, Andrei A.,Trofymchuk, Serhii,Zaporozhets, Olga A.

, p. 3110 - 3124 (2020/03/23)

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

Coordinating Activation Strategy-Induced Selective C?H Trifluoromethylation of Anilines

Xu, Jun,Cheng, Ke,Shen, Chao,Bai, Renren,Xie, Yuanyuan,Zhang, Pengfei

, p. 965 - 970 (2018/02/12)

A simple protocol for the synthesis of 2-(trifluoromethyl)aniline derivatives through a coordinating activation strategy was developed. The reaction showed good reactivity and gave the target products in moderate to good yields. Pleasingly, the directing group could be recovered in excellent yield. Furthermore, this strategy allowed efficient access to the synthesis of floctafenine. A single-electron-transfer mechanism was proposed to be responsible for this trifluoromethylation reaction.

Process route upstream and downstream products

Process route

V<sup>(647)</sup>U<sub>0370</sub>
61350-00-3

V(647)U0370

5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(I) bromide; dipotassium peroxodisulfate / acetonitrile / 12 h / 50 °C
2: hydrogenchloride / ethanol / 12 h / 100 °C
N-(5-chloro-2-(trifluoromethyl)phenyl)picolinamide

N-(5-chloro-2-(trifluoromethyl)phenyl)picolinamide

5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

Conditions
ConditionsYield
Withhydrogenchloride;Inethanol;at 100 ℃; for 12h;
Bromotrifluoromethane
75-63-8

Bromotrifluoromethane

3-chloro-aniline
108-42-9

3-chloro-aniline

5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

3-chloro-4-(trifluoromethyl)aniline
445-13-6

3-chloro-4-(trifluoromethyl)aniline

3-chloro-2-(trifluoromethyl)aniline
432-21-3

3-chloro-2-(trifluoromethyl)aniline

Conditions
ConditionsYield
Withα-picoline; sodium metabisulfite; sulfur dioxide; zinc;InN,N-dimethyl-formamide;at 65 ℃; for 3h; under 2250.2 - 3750.3 Torr;
12%
14%
12%
5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

Conditions
ConditionsYield
5-Chlor-2-trifluormethyl-benzamid, aq. Na-hypobromit, (60grad);
4-chloro-2-nitro-benzoic acid
6280-88-2

4-chloro-2-nitro-benzoic acid

5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen fluoride; sulfur tetrafluoride / 24 h / 85 °C / Autoclave; Inert atmosphere
2: ammonium chloride; iron; hydrogenchloride / water; isopropyl alcohol / Reflux
5-chloro-2-trifluoromethylnitrobenzene
25889-38-7

5-chloro-2-trifluoromethylnitrobenzene

5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

<i>N</i>-(5-chloro-2-trifluoromethyl-phenyl)-phthalimide
438-39-1

N-(5-chloro-2-trifluoromethyl-phenyl)-phthalimide

5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

Conditions
ConditionsYield
2-methoxy-ethyl p-toluenesulfonyloxy ester
17178-10-8,58320-73-3

2-methoxy-ethyl p-toluenesulfonyloxy ester

5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

chloroacetyl chloride
79-04-9

chloroacetyl chloride

2-Chloro-N-(5-chloro-2-trifluoromethyl-phenyl)-N-(2-methoxy-ethyl)-acetamide

2-Chloro-N-(5-chloro-2-trifluoromethyl-phenyl)-N-(2-methoxy-ethyl)-acetamide

Conditions
ConditionsYield
Multistep reaction; (i), (ii) /BRN= 605439/;
5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

(4aR,6R,7R,8S,8aR)-7-acetoxy-8-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

(4aR,6R,7R,8S,8aR)-7-acetoxy-8-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

(4aR,6R,7R,8S,8aR)-6-((5-chloro-2-(trifluoromethyl)phenyl)carbamoyl)-8-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-7-yl acetate

(4aR,6R,7R,8S,8aR)-6-((5-chloro-2-(trifluoromethyl)phenyl)carbamoyl)-8-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-7-yl acetate

thiophosgene
463-71-8

thiophosgene

5-chloro-2-(trifluoromethyl)aniline
445-14-7

5-chloro-2-(trifluoromethyl)aniline

4-chloro-2-isothiocyanato-1-(trifluoromethyl)benzene

4-chloro-2-isothiocyanato-1-(trifluoromethyl)benzene

Conditions
ConditionsYield
Withsodium hydrogencarbonate;Indichloromethane; water;at 0 - 20 ℃; for 18h;
54%

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