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Cas Database

448-38-4

448-38-4

Identification

  • Molecular Formula:C7H3ClF3NO3

  • EINECS:

Synonyms:4-chloro-2-nitro-1-trifluoromethoxybenzene;Trifluormethyl-(4-chlor-2-nitro-phenyl)-aether;4-chloro-2-nitrotrifluoromethoxybenzene;5-CHLORO-2-(TRIFLUOROMETHOXY)NITROBENZENE;

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Safety information and MSDS

  • Pictogram(s):

  • Hazard Codes:

  • Signal Word:

  • Hazard Statement:

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Abosyn
  • Product Description:4-chloro-2-nitro-1-(trifluoromethoxy)benzene 98+%
  • Packaging:1g
  • Price:$ 630
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:AK Scientific
  • Product Description:5-Chloro-2-(Trifluoromethoxy)nitrobenzene
  • Packaging:5g
  • Price:$ 193
  • Delivery:In stock
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  • Manufacture/Brand:Alichem
  • Product Description:3-Nitro-4-(trifluoromethoxy)chlorobenzene
  • Packaging:500mg
  • Price:$ 855.75
  • Delivery:In stock
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  • Manufacture/Brand:Alichem
  • Product Description:3-Nitro-4-(trifluoromethoxy)chlorobenzene
  • Packaging:1g
  • Price:$ 1549.6
  • Delivery:In stock
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  • Manufacture/Brand:Alichem
  • Product Description:3-Nitro-4-(trifluoromethoxy)chlorobenzene
  • Packaging:250mg
  • Price:$ 499.2
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:4-Chloro-2-nitro-1-(trifluoromethoxy)benzene 98%
  • Packaging:25g
  • Price:$ 262
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:4-Chloro-2-nitro-1-(trifluoromethoxy)benzene 98%
  • Packaging:250mg
  • Price:$ 9
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:4-Chloro-2-nitro-1-(trifluoromethoxy)benzene 98%
  • Packaging:1g
  • Price:$ 22
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Ambeed
  • Product Description:4-Chloro-2-nitro-1-(trifluoromethoxy)benzene 98%
  • Packaging:5g
  • Price:$ 74
  • Delivery:In stock
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  • Manufacture/Brand:Ambeed
  • Product Description:4-Chloro-2-nitro-1-(trifluoromethoxy)benzene 98%
  • Packaging:10g
  • Price:$ 128
  • Delivery:In stock
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Relevant articles and documentsAll total 5 Articles be found

NITRATION

-

Page/Page column 36; 37; 47; 66-67; 38; 43; 50; 68, (2020/05/28)

The present invention relates to a process for preparing a nitrated compound, comprising the step of reacting a compound (A) comprising at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein said heteroaromatic ring comprises at least one heteroatom selected from the group consisting of oxygen, sulfur, phosphor, selenium and nitrogen, with a compound of formula (I) wherein Y is selected from the group consisting of hydrogen and nitro.

LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT

-

Page/Page column 68, (2011/02/24)

Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.

Lonidamine analogues and their use in male contraception and cancer treatment

-

Page/Page column 24, (2008/06/13)

Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.

DISUBSTITUTED [4-(5-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-1H-INDOL-3-YL]-METHANONES

-

Page/Page column 66, (2011/04/13)

The present invention extends to the compound of formula I: or a prodrug, pharmaceutically acceptable salt, or solvate of said compound. Furthermore, the present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective

Co-production preparation method of o-amino trifluoromethoxy benzene and m-amino trifluoromethoxy benzene

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Paragraph 0025-0027; 0032-0034; 0044-0046, (2021/01/11)

The invention discloses a co-production preparation method of o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene, and belongs to the technical field of fine chemical engineering. Thepreparation method comprises the following steps: (1) nitration reaction: carrying out nitration reaction on 4-chlorine-trifluoromethoxybenzene to obtain a mixture of 4-chlorine-2-nitro- trifluoromethoxy benzene and 4-chlorine-3-nitro-trifluoromethoxybenzene; (2) reduction and dechlorination: carrying out reduction and dechlorination on the mixture of the 4-chloro-2-nitro-trifluoromethoxybenzene and the 4-chloro-3-nitro-trifluoromethoxybenzene to obtain o-amino trifluoromethoxybenzene and m-amino trifluoromethoxybenzene; and (3) rectification separation: separating the o-amino trifluoromethoxybenzene from the m-amino trifluoromethoxybenzene through rectification so as to realize co-production. The method is low in cost and high in yield, two useful chemical products are obtained at the same time, the process is simple, and industrial production is easy to achieve.

Process route upstream and downstream products

Process route

4-chloro-2-nitro-1-(trifluoromethoxy)benzene
448-38-4

4-chloro-2-nitro-1-(trifluoromethoxy)benzene

Conditions
ConditionsYield
Trifluormethyl-<4-chlor-phenyl>-aether, rauch. HNO3/konz. H2SO4/20-30grad/0.5 h ;
1-chloro-4-(trifluoromethoxy)benzene
461-81-4

1-chloro-4-(trifluoromethoxy)benzene

4-chloro-2-nitro-1-(trifluoromethoxy)benzene
448-38-4

4-chloro-2-nitro-1-(trifluoromethoxy)benzene

4-(trifluoromethoxy)-2-nitro-1-chlorobenzene
588-09-0

4-(trifluoromethoxy)-2-nitro-1-chlorobenzene

Conditions
ConditionsYield
Withsulfuric acid; nitric acid; at 50 ℃; for 3h;
Withsulfuric acid; nitric acid; at 0 ℃; for 1.08333h;
Withsulfuric acid; nitric acid; at 50 ℃; for 3h;
Withsulfuric acid; nitric acid; at 0 - 45 ℃; Temperature; Overall yield = 98 percent; Overall yield = 432.3 g;
4-chloro-2-nitro-1-(trifluoromethoxy)benzene
448-38-4

4-chloro-2-nitro-1-(trifluoromethoxy)benzene

4-(trifluoromethoxy)-2-nitro-1-chlorobenzene
588-09-0

4-(trifluoromethoxy)-2-nitro-1-chlorobenzene

Conditions
ConditionsYield
Withmagnesium(II) perchlorate; 2-nitrobenzo[d]isothiazol-3(2H)-one 1,1-dioxide;In[D3]acetonitrile;at 85 ℃; for 5h; Overall yield = 97 percent; Inert atmosphere; Sealed tube;
60.6%
36.4%
96.8%-sulphuric acid

96.8%-sulphuric acid

1-chloro-4-(trifluoromethoxy)benzene
461-81-4

1-chloro-4-(trifluoromethoxy)benzene

4-chloro-2-nitro-1-(trifluoromethoxy)benzene
448-38-4

4-chloro-2-nitro-1-(trifluoromethoxy)benzene

4-(trifluoromethoxy)-2-nitro-1-chlorobenzene
588-09-0

4-(trifluoromethoxy)-2-nitro-1-chlorobenzene

4-chloro-2(-3)-nitrotrifluoro-methoxybenzene
1261791-19-8

4-chloro-2(-3)-nitrotrifluoro-methoxybenzene

Conditions
ConditionsYield
96%
4-chloro-2-nitro-1-(trifluoromethoxy)benzene
448-38-4

4-chloro-2-nitro-1-(trifluoromethoxy)benzene

2-amino-4-chlorotrifluoro-methoxybenzene
326-64-7

2-amino-4-chlorotrifluoro-methoxybenzene

Global suppliers and manufacturers

Global( 8) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • SAGECHEM LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-571-86818502
  • Emails:will@sagechem.com
  • Main Products:32
  • Country:China (Mainland)
  • Bide Pharmatech Ltd
  • Business Type:Other
  • Contact Tel:021-61629020
  • Emails:sales@bidepharmatech.com
  • Main Products:1
  • Country:China (Mainland)
  • SHANGHAI ZZBIO CO., LTD.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-21-68404353-215
  • Emails:shzzbio@vip.163.com
  • Main Products:1
  • Country:China (Mainland)
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