3-Pyridinecarbonitrile,2-chloro-6-phenyl-
- CAS Number:43083-14-3
- Molecular Formula:C12H7ClN2
- Molecular Weight:214.654
- Mol File:43083-14-3.mol
Synonyms:2-Chloro-3-cyano-6-phenylpyridine;NSC 363888;
Physicochemical Properties
- Melting Point:155-159 °C
- Boiling Point:376.4 °C at 760mmHg
- Density:1.3 g/cm3
- Solubility:N/A
- Flash Point:181.4 °C
- Vapor Density:N/A
- Refractive Index:1.632
- Sensitive:N/A
- Storage Temp.:N/A
- Appearance/Colour:N/A
T3-Pyridinecarbonitrile,2-chloro-6-phenyl- Safety information and MSDS
·Hazard identification:
| Pictogram(s) | no data available |
|---|---|
| Signal word | no data available |
| Hazard statement(s) | no data available |
| Precautionary statement(s) | |
| Prevention | no data available |
| Response | no data available |
| Storage | no data available |
| Disposal | no data available |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-Chloro-6-phenylnicotinonitrile | 2-Chloro-6-phenylnicotinonitrile | 43083-14-3 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
3-Pyridinecarbonitrile,2-chloro-6-phenyl- Relevant articles
All total 8 Articles be found
All total 8 Articles be foundPYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE
-
Page/Page column 115, (2012/10/18)
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain fused triaryl amine compounds of the following formula (for convenience, collectively referred to herein as "FTA compounds"), which, inter alia, inhibit LIM kinase (LIMK) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit LIMK activity, and in the treatment of diseases and conditions that are mediated by LIMK, that are ameliorated by the inhibition of LIMK activity, etc., including proliferative conditions such as cancer (e.g., breast cancer, prostate cancer, melanoma, glioma, etc.), as well as vasodilation (including, e.g., hypertension, angina, cerebral vasospasm, and ischemia following subarachnoid hemorrhage), neurodegenerative disorders, atherosclerosis, fibrosis, and inflammatory diseases (including, e.g., Crohn's disease and chronic obstructive pulmonary disease (COPD)), and glaucoma (also known as ocular hypertension).
Pyrazolo [3,4 - the b] pyridine and [...] composition preparation method and use of (by machine translation)
-
Paragraph 0164; 0165; 0166; 0167, (2017/07/22)
The present invention provides a pyrazolo [3,4 - the b] pyridine and [...] compound of preparation and use, in particular, the present invention provides a following formula (I) compounds are shown, wherein the definition of each group as described in the specification. The compounds of the invention has excellent tyrosine kinase inhibiting activity, so can be used for preparing a series of treating diseases associated with the tyrosine kinase activity of the drug. (by machine translation)
Discovery and optimization of thienopyridine derivatives as novel urea transporter inhibitors
Zhao, Yan,Li, Min,Li, Bowen,Zhang, Shun,Su, Aoze,Xing, Yongning,Ge, Zemei,Li, Runtao,Yang, Baoxue
, p. 131 - 142 (2019/04/08)
Urea transporters (UTs) play an important role in the urine concentrating mechanism and are recognized as novel targets for developing small molecule inhibitors with salt-sparing diuretic activity. Thienoquinoline derivatives, a class of novel UT-B inhibitors identified by our group, play a significant diuresis in animal model. However, the poor solubility and low bioavailability limited its further development. To overcome these shortcomings, the structure modification of thienoquinoline was carried out in this study, which led to the discovery of novel thienopyridine derivatives as specific urea transporter inhibitors. Further optimization obtained the promising preclinical candidate 8n with not only excellent inhibition effect on urea transporters and diuretic activity on rat model, but also suitable water solubility and Log P value.
A facile method for the synthesis of nicotinonitriles from ketones via a one-pot chloromethyleneiminium salt mediated three-component reaction
Asokan,Anabha,Thomas, Ajith Dain,Jose, Ann Maria,Lethesh,Prasanth,Krishanraj
, p. 5641 - 5643 (2008/02/10)
Simple enolizable ketones such as acetophenones and benzalacetones were treated with malononitrile under Vilsmeier-Haack reaction conditions to afford 2-chloronicotinonitriles. The reaction proceeds via a one-pot chloromethyleneiminium salt mediated three
A convenient method for the synthesis of 3,5,6-trisubstituted-2- chloropyridines with bis-(trichloromethyl) carbonate
Li,Hong,Su
experimental part, p. 533 - 538 (2010/04/02)
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3-Pyridinecarbonitrile,2-chloro-6-phenyl- Synthetic route And Reaction conditions
- 43083-13-2
1,2-dihydro-2-oxo-6-phenylpyridine-3-carbonitrile
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
2-Hydroxy-3-cyan-6-phenyl-pyridin (I), PCl5, POCl3 (8h, kochen); | |
Cyanopyridon 2c, Ph-POCl2; |
- 68-12-2,33513-42-7
N,N-dimethyl-formamide
- 98-86-2
acetophenone
- 109-77-3
malononitrile
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
| 72% | |
| 52% |
- 98-86-2
acetophenone
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: 1.) sodium hydride 2: PCl5 |
- 98-80-6
phenylboronic acid
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 4 h / Reflux 2: thionyl chloride / 1 h / Reflux 3: acetic anhydride / 2 h / Reflux |
- 38496-18-3
2,6-dichloropyridine-3-carboxylic acid
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 4 h / Reflux 2: thionyl chloride / 1 h / Reflux 3: acetic anhydride / 2 h / Reflux |
- 69750-00-1
2-chloro-6-phenyl-nicotinamide
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
Withacetic anhydride;
for 2h;
Reflux; | 49% |
- 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole
- 40381-90-6
2,6-dichloro-3-pyridinecarbonitrile
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
Withdichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
sodium hydrogencarbonate;In1,2-dimethoxyethane;
water;at 90 ℃;
for 6h;
Inert atmosphere; | 63.4% |
- 108-86-1,52753-63-6
bromobenzene
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 6 h / 85 °C / Inert atmosphere 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / 6 h / 90 °C / Inert atmosphere Withdichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
potassium acetate;
sodium hydrogencarbonate;In1,4-dioxane;
1,2-dimethoxyethane;
water;2: |Suzuki Coupling; |
- 43083-13-2
3-cyano-2-hydroxy-6-phenylpyridine
- 43083-14-3
2-chloro-3-cyano-6-phenylpyridine
| Conditions | Yield |
|---|---|
Withphosphorus pentachloride;
trichlorophosphate;
at 150 ℃;
for 1h; | 93.8% |
3-Pyridinecarbonitrile,2-chloro-6-phenyl- Raw materials
- 43083-13-2
3-cyano-2-hydroxy-6-phenylpyridine
- 43083-13-2
1,2-dihydro-2-oxo-6-phenylpyridine-3-carbonitrile
- 68-12-2
N,N-dimethyl-formamide
- 98-86-2
acetophenone
- 109-77-3
malononitrile
3-Pyridinecarbonitrile,2-chloro-6-phenyl- Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(38)
United States(2)
United Kingdom(1)
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