2-(o-Tolyl)pyridine
- CAS Number:10273-89-9
- Molecular Formula:C12H11N
- Molecular Weight:169.226
- Mol File:10273-89-9.mol
Synonyms:Pyridine,2-o-tolyl- (6CI,7CI,8CI);2-(2-Methylphenyl)pyridine;2-(2-Tolyl)pyridine;2-o-Tolylpyridine;Pyridine,2-(2-methylphenyl)-;
Physicochemical Properties
- Melting Point:N/A
- Boiling Point:267.9 °C at 760 mmHg
- Density:1.03 g/cm3
- Solubility:N/A
- Flash Point:109.2 °C
- Vapor Density:N/A
- Refractive Index:1.5992 (589.3 nm 20℃)
- Sensitive:N/A
- Storage Temp.:N/A
- Appearance/Colour:N/A
2-(o-Tolyl)pyridine Safety information and MSDS
·Hazard identification:
| Pictogram(s) | no data available |
|---|---|
| Signal word | no data available |
| Hazard statement(s) | no data available |
| Precautionary statement(s) | |
| Prevention | no data available |
| Response | no data available |
| Storage | no data available |
| Disposal | no data available |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-(o-tolyl)pyridine | 2-(o-tolyl)pyridine | 10273-89-9 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
2-(o-Tolyl)pyridine Relevant articles
All total 147 Articles be found
All total 147 Articles be foundThree-Component Couplings among Heteroarenes, Difluorocyclopropenes, and Water via C-H Activation
Liu, Xuexin,Chen, Jian,Yang, Chunyan,Wu, Zhouping,Li, Zhiyang,Shi, Yuesen,Huang, Tianle,Yang, Zhongzhen,Wu, Yong
supporting information, p. 6831 - 6835 (2021/09/08)
Three-component couplings have been realized for efficiently constructing various nitrogen-containing skeletons via C-H activation, where difluorocyclopropenes have been first identified as coupling partners. Many substrates including sp2 and sp3 C-H substrates were well tolerated, furnishing the corresponding products in good yields. Furthermore, a catalyst-dependent reaction was also developed, enabling divergent construction of two different frameworks. The application value of these reactions was demonstrated in gram-scale experiments with as little as 1 mol % catalyst.
Rhodium-Catalyzed C?H Methylation and Alkylation Reactions by Carbene-Transfer Reactions
Empel, Claire,Jana, Sripati,Langletz, Tim,Koenigs, Rene M.
supporting information, (2022/02/09)
In this combined computational and experimental study, the C?H functionalization of 2-phenyl pyridine with diazoalkanes was investigated. Initial evaluation by computational methods allowed the evaluation of different metal catalysts and diazoalkanes and
Rhoda-Electrocatalyzed C?H Methylation and Paired Electrocatalyzed C?H Ethylation and Propylation
Kuciński, Krzysztof,Simon, Hendrik,Ackermann, Lutz
supporting information, (2021/11/16)
The use of electricity over traditional stoichiometric oxidants is a promising strategy for sustainable molecular assembly. Herein, we describe the rhoda-electrocatalyzed C?H activation/alkylation of several N-heteroarenes. This catalytic approach has been successfully applied to several arenes, including biologically relevant purines, diazepam, and amino acids. The versatile C?H alkylation featured water as a co-solvent and user-friendly trifluoroborates as alkylating agents. Finally, the rhoda-electrocatalysis with unsaturated organotrifluoroborates proceeded by paired electrolysis.
Evaluation of P-bridged biaryl phosphine ligands in palladium-catalysed Suzuki-Miyaura cross-coupling reactions
Holzapfel, Cedric W.,Lamola, Jairus L.,Maumela, Munaka Christopher,Moshapo, Paseka T.
, p. 26883 - 26891 (2021/08/17)
A family of biaryl phosphacyclic ligands derived from phobane and phosphatrioxa-adamantane frameworks is described. The rigid biaryl phosphacycles are efficient for Suzuki-Miyaura cross-coupling of aryl bromides and chlorides. In particular, coupling reactions of the challenging sterically hindered and heterocyclic substrates were viable at room temperature.
A recyclable self-supported nanoporous PdCu heterogeneous catalyst for aqueous Suzuki-Miyaura cross-coupling
Chen, Jie,Du, Jialei,Liu, Fushan,Wang, Bin,Wang, Leichen,Xia, Hehuan,Xiang, Daili,Xu, Caixia,Zhang, Yuanyuan,Zhao, Yiwei
supporting information, p. 11641 - 11644 (2021/11/12)
Nanoporous PdCu (NP-PdCu) was prepared by the dealloying strategy from a PdCuAl ternary alloy precursor and characterized systematically using SEM, TEM, XRD, and XPS. NP-PdCu was demonstrated to be a competent self-supported heterogenous catalyst for Suzuki-Miyaura cross-coupling, affording a series of synthetically valuable biaryl compounds in good to excellent yields. This catalyst could be easily separated from the productviacentrifugation and reused several times without obvious loss of catalytic performance.
2-(o-Tolyl)pyridine Synthetic route And Reaction conditions
- 105902-01-0
6-o-tolyl-2,3,4,5-tetrahydro-pyridine
- 10273-89-9
2-(2-methylphenyl)pyridine
| Conditions | Yield |
|---|---|
Withpalladium on activated charcoal;
1-allyl-3,4-methylenedioxybenzene;
at 190 ℃; |
| Conditions | Yield |
|---|---|
| 67% | |
| 32% | |
Withnickel;Inert atmosphere; | |
WithNi-catalyst; | |
Withnickel catalyst;Inert atmosphere; |
- 5029-67-4
2-iodopyridine
- 109-09-1
2-chloropyridine
- 4467-06-5
2-(4-methylphenyl)pyridine
- 10273-89-9
2-(2-methylphenyl)pyridine
- 4373-61-9
2-(m-tolyl)pyridine
| Conditions | Yield |
|---|---|
Indichloromethane;for 15h;
Yield given. Yields of byproduct given;
Ambient temperature;
Irradiation; | 19% |
- 5029-67-4
2-iodopyridine
- 4467-06-5
2-(4-methylphenyl)pyridine
- 10273-89-9
2-(2-methylphenyl)pyridine
- 4373-61-9
2-(m-tolyl)pyridine
| Conditions | Yield |
|---|---|
Irradiation;
other substituted benzenes, five membered heterocycles and indoles; |
- 33421-20-4
2-(2-methylphenyl)pyridine N-oxide
- 110-86-1
pyridine
- 10273-89-9
2-(2-methylphenyl)pyridine
- 244-99-5
4-azafluorene
| Conditions | Yield |
|---|---|
at 800 ℃;
for 0.25h;
under 0.05 - 0.2 Torr; | 69% 11% 11% |
- 98061-37-1
1-(2-(pyridin-2-yl)phenyl)methanol
- 10273-89-9
2-(2-methylphenyl)pyridine
| Conditions | Yield |
|---|---|
| 5 mg |
- 78715-82-9
1,2,3,5-thiatriazolo<5,4-a>pyridine 3-oxide
- 4467-06-5
2-(4-methylphenyl)pyridine
- 10273-89-9
2-(2-methylphenyl)pyridine
| Conditions | Yield |
|---|---|
Withanthracene;
for 2h;
Heating; | 19% 19% |
| Conditions | Yield |
|---|---|
| Conditions | Yield |
|---|---|
Withmanganese;
nickel bromide 2,2’-bipyridine complex;
trifluoroacetic acid;InN,N-dimethyl-formamide;at 60 ℃;
for 1h; | 61% |
With(2,2'-bipyridine)nickel(II) dibromide;
tetrabutylammonium tetrafluoroborate;InN,N-dimethyl-formamide;Ambient temperature;
electrolysis; | 30% |
2-(o-Tolyl)pyridine Raw materials
- 110-86-1
pyridine
- 105902-01-0
6-o-tolyl-2,3,4,5-tetrahydro-pyridine
- 109-04-6
2-bromo-pyridine
- 932-31-0
ortho-tolylmagnesium bromide
- 16419-60-6
2-Methylphenylboronic acid
2-(o-Tolyl)pyridine Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(14)
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- Total:13 Page 1 of 1 1
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