Benzoic acid,2-phenoxy-, hydrazide
- CAS Number:43038-37-5
- Molecular Formula:C13H12N2O2
- Molecular Weight:228.25
- Mol File:43038-37-5.mol
Synonyms:2-Phenoxybenzoic acid hydrazide;
Physicochemical Properties
- Melting Point:99 °C
- Boiling Point:N/A
- Density:1.217 g/cm3
- Solubility:N/A
- Flash Point:N/A
- Vapor Density:N/A
- Refractive Index:1.612
- Sensitive:N/A
- Storage Temp.:N/A
- Appearance/Colour:N/A
Benzoic acid,2-phenoxy-, hydrazide Safety information and MSDS
·Hazard identification:
| Pictogram(s) |  |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. |
| Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-Phenoxybenzhydrazide | 2-Phenoxybenzhydrazide | 43038-37-5 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Benzoic acid,2-phenoxy-, hydrazide Relevant articles
All total 6 Articles be found
All total 6 Articles be foundSynthesis, antitubercular activity and docking study of novel cyclic azole substituted diphenyl ether derivatives
Kini, Suvarna G.,Bhat, Anilchandra R.,Bryant, Byron,Williamson, John S.,Dayan, Franck E.
experimental part, p. 492 - 500 (2009/08/07)
The re-emergence of tuberculosis (TB) as a global health problem over the past few decades, accompanied by the rise of drug-resistant strains of Mycobacterium tuberculosis, emphasizes the need for discovery of new therapeutic drugs against this disease. The emerging serious problem both in terms of TB control and clinical management prompted us to synthesize a novel series of heterocyclic o/m/p substituted diphenyl ether derivatives and determine their activity against H37Rv strain of Mycobacterium. All 10 compounds inhibited the growth of the H37Rv strain of mycobacterium at concentrations as low as 1 μg/mL. This level of activity was found comparable to the reference drugs rifampicin and isoniazid at the same concentration. Molecular modeling of the binding of the diphenyl ether derivatives on enoyl-ACP reductase, the molecular target site of triclosan, indicated that these compounds fit within the binding domain occupied by triclosan. Hence the diphenyl ether derivatives tested in this study were docked to ENR and the binding of the diphenyl ether derivatives was also estimated using a variety of scoring functions that have been compiled into the single consensus score. As the scores ranged from 47.27% to 65.81%, these bioactive compounds appear to have a novel mechanism of action against M. tuberculosis, and their structural features should be studied further for their potential use as new antitubercular drugs.
Synthesis of new thiazolo[3,2-b][1,2,4]triazole-6(5H)-one derivatives as potent analgesic and anti-inflammatory agents
Assarzadeh, Mohammad Javad,Almasirad, Ali,Shafiee, Abbas,Koopaei, Mansur Nassiri,Abdollahi, Mohammad
, p. 948 - 957 (2014/03/21)
A series of thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones were synthesized and evaluated for their analgesic and anti-inflammatory activities. The structures of these compounds were supported by FT-IR, 1HNMR, and Mass spectra. All of the final comp
Structural design, synthesis and substituent effect of hydrazone-N-acylhydrazones reveal potent immunomodulatory agents
Meira, Cássio S.,dos Santos Filho, José Maurício,Sousa, Caroline C.,Anjos, Pamela S.,Cerqueira, Jéssica V.,Dias Neto, Humberto A.,da Silveira, Rafael G.,Russo, Helena M.,Wolfender, Jean-Luc,Queiroz, Emerson F.,Moreira, Diogo R.M.,Soares, Milena B.P.
, p. 1971 - 1985 (2018/03/12)
4-(Nitrophenyl)hydrazone derivatives of N-acylhydrazone were synthesized and screened for suppress lymphocyte proliferation and nitrite inhibition in macrophages. Compared to an unsubstituted N-acylhydrazone, active compounds were identified within initial series when hydroxyl, chloride and nitro substituents were employed. Structure-activity relationship was further developed by varying the position of these substituents as well as attaching structurally-related substituents. Changing substituent position revealed a more promising compound series of anti-inflammatory agents. In contrast, an N-methyl group appended to the 4-(nitrophenyl)hydrazone moiety reduced activity. Anti-inflammatory activity of compounds is achieved by modulating IL-1β secretion and prostaglandin E2 synthesis in macrophages and by inhibiting calcineurin phosphatase activity in lymphocytes. Compound SintMed65 was advanced into an acute model of peritonitis in mice, where it inhibited the neutrophil infiltration after being orally administered. In summary, we demonstrated in great details the structural requirements and the underlying mechanism for anti-inflammatory activity of a new family of hydrazone-N-acylhydrazone, which may represent a valuable medicinal chemistry direction for the anti-inflammatory drug development in general.
NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
-
Page/Page column 16, (2009/04/25)
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine recept
Designing and exploring active N′-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against three Trypanosoma cruzi strains more prevalent in Chagas disease patients
De Azevedo, Ricardo Alexandre,Ferreira, Adilson Kleber,Jorge, Salomo Dria,Palace-Berl, Fanny,Pasqualoto, Kerly Fernanda Mesquita,Silva, Marcelo Nunes,Tavares, Leoberto Costa,Teixeira, Sarah Fernandes,Zingales, Bianca,Zorzi, Rodrigo Rocha
, p. 330 - 339 (2015/04/27)
Chagas disease affects around 8 million people worldwide and its treatment depends on only two nitroheterocyclic drugs, benznidazole (BZD) and nifurtimox (NFX). Both drugs have limited curative power in chronic phase of disease. Nifuroxazide (NF), a nitroheterocyclic drug, was used as lead to design a set of twenty one compounds in order to improve the anti-Trypanosoma cruzi activity. Lipinski's rules were considered in order to support drug-likeness designing. The set of N′-[(5-nitrofuran-2-yl) methylene] substituted hydrazides was assayed against three T. cruzi strains, which represent the discrete typing units more prevalent in human patients: Y (TcII), Silvio X10 cl1 (TcI), and Bug 2149 cl10 (TcV). All the derivatives, except one, showed enhanced trypanocidal activity against the three strains as compared to BZD. In the Y strain 62% of the compounds were more active than NFX. The most active compound was Ng€2-((5-nitrofuran-2-yl) methylene)biphenyl-4-carbohydrazide (C20), which showed IC50 values of 1.17 ± 0.12 μM; 3.17 ± 0.32 μM; and 1.81 ± 0.18 μ4M for Y, Silvio X10 cl1, and Bug 2149 cl10 strains, respectively. Cytotoxicity assays with human fibroblast cells have demonstrated high selectivity indices for several compounds. Exploratory data analysis indicated that primarily topological, steric/geometric, and electronic properties have contributed to the discrimination of the set of investigated compounds. The findings can be helpful to drive the designing, and subsequently, the synthesis of additional promising drugs against Chagas disease.
Benzoic acid,2-phenoxy-, hydrazide Synthetic route And Reaction conditions
- 21905-56-6
methyl 2-phenoxybenzoate
- 43038-37-5
2-phenoxybenzoic acid hydrazide
| Conditions | Yield |
|---|---|
Withhydrazine hydrate;Inmethanol; | |
Withhydrazine hydrate;
at 20 ℃; | |
- 41755-76-4
ethyl 2-phenoxybenzoate
- 43038-37-5
2-phenoxybenzoic acid hydrazide
| Conditions | Yield |
|---|---|
Withhydrazine hydrate; |
- 2243-42-7
2-phenoxybenzoic acid
- 43038-37-5
2-phenoxybenzoic acid hydrazide
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: H2SO4 2: NH2NH2*H2O / methanol Withsulfuric acid;
hydrazine hydrate;Inmethanol; | |
Multi-step reaction with 2 steps 1: H2SO4 2: N2H4+H2O | |
Multi-step reaction with 2 steps 1: sulfuric acid / Reflux 2: hydrazine hydrate / 20 °C | |
Multi-step reaction with 2 steps 1: sulfuric acid / Reflux 2: hydrazine hydrate / ethanol / 70 °C Withsulfuric acid;
hydrazine hydrate;Inethanol; | |
| Conditions | Yield |
|---|---|
| Conditions | Yield |
|---|---|
carbon disulfide;
2-phenoxybenzoic acid hydrazide;Withpotassium hydroxide;Inethanol;for 18h;
Reflux; Withhydrogenchloride;Inwater; | 87% |
- 653-37-2
perfluorobenzaldehyde
- 43038-37-5
2-phenoxybenzoic acid hydrazide
| Conditions | Yield |
|---|---|
| 71% |
- 43038-37-5
2-phenoxybenzoic acid hydrazide
- 66-77-3
1-naphthaldehyde
| Conditions | Yield |
|---|---|
| 58% |
- 43038-37-5
2-phenoxybenzoic acid hydrazide
- 618429-99-5
5-(2-phenoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 19 h / Reflux 2: sodium hydroxide / 5 h / Reflux Withhydrogenchloride;
sodium hydroxide;Inwater; |
- 43038-37-5
2-phenoxybenzoic acid hydrazide
- 18804-75-6
1-(2-(4-nitrophenyl)hydrazono)propan-2-one
| Conditions | Yield |
|---|---|
| 91% |
- 43038-37-5
2-phenoxybenzoic acid hydrazide
- 19434-34-5
2-(phenoxy)benzaldehyde
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 2: Na2CO3; ethylene glycol |
Benzoic acid,2-phenoxy-, hydrazide Raw materials
- 41755-76-4
ethyl 2-phenoxybenzoate
- 21905-56-6
methyl 2-phenoxybenzoate
- 2243-42-7
2-phenoxybenzoic acid
- 40501-36-8
2-phenoxybenzoyl chloride
Benzoic acid,2-phenoxy-, hydrazide Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(12)
United Kingdom(1)
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