Benzaldehyde, 3-bromo-5-fluoro-2-hydroxy-
- CAS Number:178546-34-4
- Molecular Formula:C7H4BrFO2
- Molecular Weight:219.01
- Mol File:178546-34-4.mol
Synonyms:PC2607;3-bromo-5-fluoro-2-hydroxy-benzaldehyde;
Physicochemical Properties
- Melting Point:N/A
- Boiling Point:N/A
- Density:N/A
- Solubility:N/A
- Flash Point:N/A
- Vapor Density:N/A
- Refractive Index:N/A
- Sensitive:N/A
- Storage Temp.:N/A
- Appearance/Colour:N/A
Benzaldehyde, 3-bromo-5-fluoro-2-hydroxy- Safety information and MSDS
·Hazard identification:
Pictogram(s) | no data available |
---|---|
Signal word | no data available |
Hazard statement(s) | no data available |
Precautionary statement(s) | |
Prevention | no data available |
Response | no data available |
Storage | no data available |
Disposal | no data available |
·Composition/information on ingredients:
Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
---|---|---|---|---|
3-bromo-5-fluoro-2-hydroxybenzaldehyde | 3-bromo-5-fluoro-2-hydroxybenzaldehyde | 178546-34-4 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Benzaldehyde, 3-bromo-5-fluoro-2-hydroxy- Relevant articles
All total 6 Articles be found
NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE
-
Page/Page column 21, (2008/06/13)
[From equivalent EP1710233A1] The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, arylalkenyl, aryloxy-lower alkyl, heteroaryl, heteroaryl-lower alkyl, etc; R3, R4, R5 and R6 are each hydrogen, halogen, cyano, lower alkyl, halo-lower alkyl, lower alkoxy, hydroxy, aryl, etc; provided that at least one of R3, R4, R5 and R6 is other than hydrogen. Compound (I) of the present invention shows a potent adenosine A2A receptor antagonistic activity, and are useful for treating or preventing a disease mediated by adenosine A2A receptors such as motor function disorders, depression, anxiety disorders, cognitive function disorders, cerebral ischemia disorders, restless legs syndrome and the like.
Imidazo ring PAR4 antagonist and medical applications thereof
-
Paragraph 0383-0386, (2020/01/12)
The invention relates to an imidazo ring compound represented by formula (I) or formula (II), or a pharmaceutically acceptable salt or ester or solvate thereof. The compound disclosed by the inventioncan be used for preparing medicines for preventing or treating thromboembolic diseases.
Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners
-
Page/Page column 184, (2008/12/05)
The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with hyperproliferation, such as cancer.
BENZO-FUSED HETEROCYCLIC DERIVATIVES USEFUL AS AGONISTS OF GPR120
-
Paragraph 0534, (2014/09/30)
The present invention is directed to benzo-fused heterocyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by GPR120. More particularly, the compounds of the present invention are agonists of GPR120, useful in the treatment of, such as for example, Type II diabetes mellitus.
2-CARBOXAMIDE-7-PIPERAZINYL-BENZOFURAN DERIVATIVES 774
-
Page/Page column 32, (2011/01/05)
The present invention relates to compounds of formula (I), wherein R1 is heteroaryl or heterocyclyl, optionally substituted;R2 is C1-4alkyl, heterocyclyl, C1-4alkylaryl, C1-4alkylheteroaryl, carbocycl
Benzaldehyde, 3-bromo-5-fluoro-2-hydroxy- Synthetic route And Reaction conditions
- 50-00-0,30525-89-4,61233-19-0
formaldehyd
- 496-69-5
2-bromo-4-fluoro-phenol
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde

Conditions | Yield |
---|---|
93% |
- 347-54-6
5-fluoro-2-hydroxybenzaldehyde
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde

Conditions | Yield |
---|---|
- 100-97-0
hexamethylenetetramine
- 496-69-5
2-bromo-4-fluoro-phenol
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde

Conditions | Yield |
---|---|
Withsulfuric acid;
water;
at 20 ℃;
for 3h; | 83% |
Withtrifluoroacetic acid;
for 10h;
Reflux; | 73% |
Withtrifluoroacetic acid;
at 80 ℃; | |
hexamethylenetetramine;
2-bromo-4-fluoro-phenol;Withtrifluoroacetic acid;
at 20 ℃;
for 20h;
Heating / reflux; Withsulfuric acid;
water;
at 20 ℃;
for 4h; |
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde

Conditions | Yield |
---|---|
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde
- 74-88-4
methyl iodide
- 1009093-60-0
3-bromo-5-fluoro-2-methoxybenzaldehyde

Conditions | Yield |
---|---|
89% | |
3-bromo-5-fluoro-2-hydroxybenzaldehyde;Withpotassium carbonate;InN,N-dimethyl-formamide;at 20 ℃;
for 0.166667h; |
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde
- 96-34-4
methyl chloroacetate
- 550998-61-3
7-bromo-5-fluoro-1-benzofuran-2-carboxylic acid

Conditions | Yield |
---|---|
3-bromo-5-fluoro-2-hydroxybenzaldehyde;
methyl chloroacetate;Withpotassium carbonate;tetra-(n-butyl)ammonium iodide;at 130 ℃;
for 4h; Withhydrogenchloride;Inwater; | 63% |
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde

Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / methanol / 60 °C 3: toluene-4-sulfonic acid / toluene / 70 °C 4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 30 °C 5: water; hydrogenchloride / acetone / 2 h / 30 °C 6: triethylamine / dichloromethane / 30 °C 7: potassium carbonate / N,N-dimethyl-formamide / 30 °C |
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde

Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / methanol / 60 °C 3: toluene-4-sulfonic acid / toluene / 70 °C 4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 30 °C 5: water; hydrogenchloride / acetone / 2 h / 30 °C 6: triethylamine / dichloromethane / 30 °C 7: potassium carbonate / N,N-dimethyl-formamide / 30 °C 8: trifluoroacetic acid / dichloromethane / 3 h / 30 °C |
- 503-87-7
2-thiohydantoin
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde

Conditions | Yield |
---|---|
29% |
- 178546-34-4
3-bromo-5-fluoro-2-hydroxybenzaldehyde

Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C 1.2: 20 °C 2.1: sodium hydroxide; hydroxylamine hydrochloride / tetrahydrofuran; methanol; water / 1 h / 20 °C |
Benzaldehyde, 3-bromo-5-fluoro-2-hydroxy- Raw materials
- 347-54-6
5-fluoro-2-hydroxybenzaldehyde
- 100-97-0
hexamethylenetetramine
- 496-69-5
2-bromo-4-fluoro-phenol
- 50-00-0
formaldehyd
Benzaldehyde, 3-bromo-5-fluoro-2-hydroxy- Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(13)
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