1-(5-bromo-2-hydroxyphenyl)propan-1-one Safety information and MSDS
·Hazard identification:
Pictogram(s)
Signal word
Danger
Hazard statement(s)
H301 Toxic if swallowed
Precautionary statement(s)
Prevention
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor/…
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage
P405 Store locked up.
Disposal
P501 Dispose of contents/container to ...
·Composition/information on ingredients:
Chemical name
Common names and synonyms
CAS number
EC number
Concentration
5'-BROMO-2'-HYDROXYPROPIOPHENONE 97
5'-BROMO-2'-HYDROXYPROPIOPHENONE 97
17764-93-1
none
100%
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Synthesis of the potassium channel opener (3S,4R)-3,4-dihydro-4-(2,3- dihydro-2-methyl-3-oxo-pyridazin-6-yl)oxy-3-hydroxy-6-(3-hydroxyphenyl) sulphonyl-2,2,3-trimethyl-2H-benzo[b]pyran
Magano, Javier,Acciacca, Allison,Beylin, Vladimir,Spence, Julie,Dunn, Peter,Hughes, Mike
, p. 3569 - 3578 (2008/03/14)
The preparation of the potassium channel opener (3S,4R)-3,4-dihydro-4-(2,3- dihydro-2-methyl-3-oxo-pyridazin-6-yl)oxy-3-hydroxy-6-(3-hydroxyphenyl) sulphonyl-2,2,3-trimethyl-2H-benzo[b]pyran (1) as a single enantiomer is reported. Considerable improvement
Intramolecular ketone-olefin radical cyclization with low-valent titanium reagent: Synthesis of benzopyrans
Nayak, Sandip K.,Bhatt, Suchitra,Roy, Kshama
scheme or table, p. 2969 - 2975 (2010/11/05)
A novel protocol for intramolecular ketyl-olefin radical cyclization with low-valent titanium reagent is outlined. It allows the formation of the benzopyran nucleus from ortho-allyloxy propiophenones as the sole product in moderate yields via intramolecular radical cyclization. Copyright Taylor & Francis Group, LLC.
A compound of the formula: STR1 or a pharmaceutically acceptable salt thereof, wherein X is O, S or NH; R and R1 are each independently selected from H and C1 -C4 alkyl or taken together represent C2 -C6 alkylene; R2 is H or C1 -C4 alkyl; R3 is a 6-membered heterocyclic ring containing 2N hetero-atoms, said ring being linked to X by a ring carbon atom, optionally benzo-fused and optionally substituted, including in the benzo-fused portion, by C1 -C6 alkyl, hydroxy, --OR5, halo, --S(O)m R5, oxo, amino, --NHR5, --N(R5)2, cyano, --CO2 R5, --CONH2, --CONHR5 or --CON(R5)2, with the proviso that R3 is not an N--(C1 -C6 alkyl)pyridonyl group; R4 is phenyl substituted by a hydroxy group and optionally further substituted by 1 or 2 substitutents each independently selected from hydroxy, C1 -C6 alkyl, --OR5, halo, cyano and nitro; R5 is C1 -C6 alkyl; R6 is --OR5, --NHR5, --N(R5)2, --SR5 or --NHR9 ; R7 is cyano; R8 is --OR5, --NHR5, --N(R5)2, or --NHR9 ; R9 is phenyl optionally substituted by C1 -C6 alkyl, hydroxy, --OR5, halo, cyano or nitro; and m is 0, 1 or 2.
The present invention relates to compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein the dashed line represents an optional covalent bond; X is O, NH, S or a direct link; R. sup.3 is hydroxy when the dashed line does not represent a covalent bond and R 3 is absent when the dashed line represents a covalent bond; R. sup.4 is (a), when X is O, a group of formula (i), (b), when X is O, NH or S, optionally substituted hydroxyphenyl, (c) an optionally substituted 4-to 7-membered heterocyclic ring, or (d), when X is NH, a group of formula (ii). The compounds are useful for the treatment of disease associated with the altered tone or motility of smooth muscle. STR1
A Baker-Venkataraman retro-Claisen cascade delivers a novel alkyl migration process for the synthesis of amides
Ameen, Dana,Snape, Timothy J.
supporting information, p. 1816 - 1819 (2015/03/30)
A simple extension of the carbamoyl Baker-Venkataraman rearrangement has been developed. If residual water in the reaction is not strictly excluded a Baker-Venkataraman retro-Claisen cascade takes place, giving amide products, in which an alkyl group apparently migrates between two functionalities of the substrate.
1-(5-bromo-2-hydroxyphenyl)propan-1-one Synthetic route And Reaction conditions