1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- CAS Number:17708-90-6
- Molecular Formula:C42H80NO8P
- Molecular Weight:758.073
- Mol File:17708-90-6.mol
Synonyms:3-sn-Phosphatidylcholine, 2-linoleoyl-1-palmitoyl
Physicochemical Properties
- Melting Point:N/A
- Boiling Point:N/A
- Density:N/A
- Solubility:N/A
- Flash Point:N/A
- Vapor Density:N/A
- Refractive Index:N/A
- Sensitive:N/A
- Storage Temp.:?20°C
- Appearance/Colour:N/A
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE Safety information and MSDS
·Hazard identification:
| Pictogram(s) | no data available |
|---|---|
| Signal word | no data available |
| Hazard statement(s) | no data available |
| Precautionary statement(s) | |
| Prevention | no data available |
| Response | no data available |
| Storage | no data available |
| Disposal | no data available |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| L-alpha-lecithin | L-alpha-lecithin | 17708-90-6 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE Relevant articles
All total 16 Articles be found
All total 16 Articles be foundSynthesis of phosphatidylcholine with conjugated linoleic acid and studies on its cytotoxic activity
Niezgoda, Natalia,Mitula, Pawel,Kempinska, Katarzyna,Wietrzyk, Joanna,Wawrzenczyk, Czeslaw
, p. 354 - 361 (2013/05/22)
Phospholipids with conjugated linoleic acid (CLA), which are potential lipid prodrugs, were synthesised. CLA was obtained by the alkali-isomerisation of linoleic acid and was subsequently used in the synthesis of 1,2-di(conjugated)linoleoyl-sn-glycero-3-phosphocholine in good (82%) yield. 1-Palmitoyl-2-(conjugated)linoleoyl-sn-glycero-3-phosphocholine was obtained by a two-step synthesis in 87% yield. All the compounds were tested in an in vitro cytotoxicity assay against two human cancer cell lines, HL-60 and MCF-7, and a mouse fibroblast cell line, Balb/3T3. The free form of CLA exhibited the highest activity against all cancer cell lines. Results obtained for the Balb/3T3 line proved that phosphatidylcholine derivatives decreased the cytotoxic effect of CLA against healthy cell lines.
Solid galenical form for oral administration, and the process for its preparation
-
, (2008/06/13)
New solid galenical form for oral administration, consisting of a mixture of one or more active products and two or more excipients which can be liquefied at a temperature compatible with the active product or products, and which are solid at ambient temperature.
Potentiated sulfonamide injectable preparation
-
, (2008/06/13)
Potentiated sulfonamide compositions useful for intramuscular injection are disclosed which comprise mixtures of alkali metal sulfonamides with microcrystalline potentiators wherein the microcrystals have been coated with mixtures of phospholipids and non-ionic surfactants. The compositions are advantageous in that they can be used extemporaneously by addition of sterile water for injection, the resulting aqueous preparation is stable for long periods of time and upon use the compositions are characterized by syringeability and lack of irritation at the injection site.
Novel pharmaceutical composition of ceftiofur
-
, (2008/06/13)
The present invention relates to a pharmaceutical oily suspension comprising cephalosporin antibiotic or its pharmaceutically acceptable salt, at least a biocompatible oil, a wetting agent, a dispersing agent and a resuspendibility enhancer, said suspension has improved properties, such as resuspendibility and chemical stability and process thereof.
NOVEL FORMULATION OF DEHYDRATED LIPID VESICLES FOR CONTROLLED RELEASE OF ACTIVE PHARMACEUTICAL INGREDIENT VIA INHALATION
-
, (2009/03/07)
A new formulation of dehydrated lipid vesicles employs a vesicle preserver and permits the control of release and delivery of active pharmaceutical ingredients into the respiratory system for treatment in particular of asthma. The typical formulation provides controlled release of the active pharmaceutical ingredient from 0% to 100% from 0 to 72 hours after inhalation, changes the systemic administration to topical administration, allows prolonged therapeutic period for one administration, increased stability, with reduced dose, reduced systemic side effects, reduced toxicity.
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE Synthetic route And Reaction conditions
- 1455-05-6
2-chloroethyl phosphorodichloridate
- 65886-78-4
1-O-palmitoyl-2-arachidonoyl-glycerol
- 75-50-3
trimethylamine
| Conditions | Yield |
|---|---|
2-chloroethyl phosphorodichloridate;
1-O-palmitoyl-2-arachidonoyl-glycerol;Withtriethylamine;Indichloromethane; Withwater;
triethylamine;Indichloromethane; | 58.9% |
- 17364-16-8,17364-17-9,17364-18-0,14863-27-5
1-palmitoyl-sn-glycero-3-phosphocholine
| Conditions | Yield |
|---|---|
| 77% |
- 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid
| Conditions | Yield |
|---|---|
Multi-step reaction with 3 steps 1.1: DMAP; DCC / CH2Cl2 / 24 h / 20 °C 2.1: ethanol / 6 h / 20 °C / UV-irradiation 3.1: Et3N / CH2Cl2 3.2: H2O; Et3N / CH2Cl2 3.3: 58.9 percent / ethanol / 72 h / 70 - 80 °C Withdmap;
triethylamine;
dicyclohexyl-carbodiimide;Inethanol;
dichloromethane;1.1: Esterification / 2.1: deprotection / 3.1: phosphorylation / 3.2: Hydrolysis / 3.3: Substitution; |
- 57-10-3
1-hexadecylcarboxylic acid
| Conditions | Yield |
|---|---|
Multi-step reaction with 4 steps 1.1: 75.3 percent / DMAP; DCC / CH2Cl2 / 0 °C 2.1: DMAP; DCC / CH2Cl2 / 24 h / 20 °C 3.1: ethanol / 6 h / 20 °C / UV-irradiation 4.1: Et3N / CH2Cl2 4.2: H2O; Et3N / CH2Cl2 4.3: 58.9 percent / ethanol / 72 h / 70 - 80 °C Withdmap;
triethylamine;
dicyclohexyl-carbodiimide;Inethanol;
dichloromethane;1.1: Esterification / 2.1: Esterification / 3.1: deprotection / 4.1: phosphorylation / 4.2: Hydrolysis / 4.3: Substitution; |
- 1487-50-9
1-O-hexadecanoyl-3-O-benzyl-sn-glycerol
| Conditions | Yield |
|---|---|
Multi-step reaction with 3 steps 1.1: 65.5 percent / DMAP; DCC / CH2Cl2 / 24 h / 20 °C 2.1: 88 percent / BCl3 / CH2Cl2 / -78 - -40 °C 3.1: Et3N / CH2Cl2 3.2: H2O; Et3N / CH2Cl2 3.3: 58.9 percent / ethanol / 72 h / 70 - 80 °C Withdmap;
boron trichloride;
triethylamine;
dicyclohexyl-carbodiimide;Indichloromethane;1.1: Esterification / 2.1: debenzylation / 3.1: phosphorylation / 3.2: Hydrolysis / 3.3: Substitution; |
- 256494-17-4
1-O-palmitoyl-3-[methyl α-(2,4-dinitrophenyl)acetate]glycerol
| Conditions | Yield |
|---|---|
Multi-step reaction with 3 steps 1.1: DMAP; DCC / CH2Cl2 / 24 h / 20 °C 2.1: ethanol / 6 h / 20 °C / UV-irradiation 3.1: Et3N / CH2Cl2 3.2: H2O; Et3N / CH2Cl2 3.3: 58.9 percent / ethanol / 72 h / 70 - 80 °C Withdmap;
triethylamine;
dicyclohexyl-carbodiimide;Inethanol;
dichloromethane;1.1: Esterification / 2.1: deprotection / 3.1: phosphorylation / 3.2: Hydrolysis / 3.3: Substitution; |
- 256494-15-2
1-O-palmitoyl-2-arachidonoyl-3-benzylglycerol
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1.1: 88 percent / BCl3 / CH2Cl2 / -78 - -40 °C 2.1: Et3N / CH2Cl2 2.2: H2O; Et3N / CH2Cl2 2.3: 58.9 percent / ethanol / 72 h / 70 - 80 °C Withboron trichloride;
triethylamine;Indichloromethane;1.1: debenzylation / 2.1: phosphorylation / 2.2: Hydrolysis / 2.3: Substitution; |
- 256494-19-6
1-O-palmitoyl-2-arachidonoyl-3-[methyl α-(2,4-dinitrophenyl)acetate]glycerol
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1.1: ethanol / 6 h / 20 °C / UV-irradiation 2.1: Et3N / CH2Cl2 2.2: H2O; Et3N / CH2Cl2 2.3: 58.9 percent / ethanol / 72 h / 70 - 80 °C Withtriethylamine;Inethanol;
dichloromethane;1.1: deprotection / 2.1: phosphorylation / 2.2: Hydrolysis / 2.3: Substitution; |
| Conditions | Yield |
|---|---|
| 87.4% | |
- 57-55-6,63625-56-9
propylene glycol
| Conditions | Yield |
|---|---|
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE Raw materials
- 1455-05-6
2-chloroethyl phosphorodichloridate
- 65886-78-4
1-O-palmitoyl-2-arachidonoyl-glycerol
- 75-50-3
trimethylamine
- 60-33-3
linoleic acid
- 17364-16-8
1-palmitoyl-sn-glycero-3-phosphocholine
1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(1)
Recommended products
- nonaethyleneglycol mono(p-toluenesulfonyl) ether
- 4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one
- 3-chloro-2',5’-dimethylbiphenyl
- N-(1-(3-methyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)ethyl)benzamide
- dimethyl benzyloxycarbonylphosphonate
- 2,6-diethyl-1,3,5,7-tetramethyl-8-(2-methoxyphenyl)-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
- 4-(2-(piperidin-1-yl)ethyl)pyridine
- N-[(Benzyl-trimethylsilanylmethyl-amino)-methyl]-thioacetamide
- N-[6-(2,4-difluorophenoxy)-1-hydroxy-5-indanyl]methanesulfonamide
- Benzylpenilloaldehyd-dimethylacetal
- (E)-1,2-bis(3-bromothiophen-2-yl)ethene
- 1-(3-methoxyphenyl)-2-(triphenyl-λ5-phosphaneylidene)ethan-1-one
- 9,10-bis(4-methoxybenzyl)anthracene
- 4-(4-n-Pentyl-1-piperidyl)-3-cyclohexen-1-carbosaeure-methylester
- cyano-1 dimethyl-3,4 (N-methylanilino)-1 cyclohexene-3
- Total:1 Page 1 of 1 1
Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields
