2-Amino-6-bromo-4-chlorophenol
- CAS Number:179314-60-4
- Molecular Formula:C6H5BrClNO
- Molecular Weight:222.469
- Mol File:179314-60-4.mol
Synonyms:2-Amino-6-bromo-4-chlorophenol
Physicochemical Properties
- Melting Point:83-87°C
- Boiling Point:N/A
- Density:N/A
- Solubility:N/A
- Flash Point:N/A
- Vapor Density:N/A
- Refractive Index:N/A
- Sensitive:N/A
- Storage Temp.:2-8°C
- Appearance/Colour:N/A
2-Amino-6-bromo-4-chlorophenol Safety information and MSDS
·Hazard identification:
| Pictogram(s) |  |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. |
| Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-amino-6-bromo-4-chlorophenol | 2-amino-6-bromo-4-chlorophenol | 179314-60-4 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
2-Amino-6-bromo-4-chlorophenol Relevant articles
All total 3 Articles be found
All total 3 Articles be foundNOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS
-
Page/Page column 111, (2010/06/22)
The present invention relates to benzodioxane and benzoxazine derivatives that act as ligands for CC chemokine receptors, such as CCR1. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
COMPOUNDS AND COMPOSITIONS AS RAF KINASE INHIBITORS
-
Paragraph 00336, (2016/04/20)
The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
6,5-Fused aromatic ring systems having enhanced phosphodiesterae IV inhibitory activity
-
, (2008/06/13)
Novel compounds which are effective PDE IV inhibitors are disclosed. The compounds possess improved PDE IV inhibition as compared to theophylline or rolipram, with improved selectivity with regard to, e.g., PDE V inhibition. The present invention includes compounds of Formula I: wherein:rings "A" and "B" can be saturated, unsaturated or partially unsaturated;X1 is selected from CH, C-Cl, or N;X2 is selected from CR12 or N;X3 is selected from CH or N;X4 is selected from CH or N;P1, P2 are independently selected from CH,O or N or NH;M is selected from CH, C, or N;Q is C1-C3 alkyl or -CH=CH-;R6 is selected from -C(R9)3, CH(R9)2, or C3-C8 cycloalkyl;R7 is selected from -OH, -O-CO-CH3, -SH, or -CHO;R8 is selected from -C(R9)3, -CH(R9)2, -C3-C8-cycloalkyl, or -CH2-C4-C6-cycloalkyl;R10 is selected from C1-C3-pyridyl, C3H6OH,-C= C-, Br, -C=C-CH2OH, isopropyl, hydrogen, andR11 is selected from H, -OH, -O-C3-C8-cycloalkyl, -NH2, -NH-C1-C3-alkyl, -SH, -NH-C3-C8-cycloalkyl, -Z-pyridyl, -Z-trienyl, and -Z-CH2OH;R12 is selected from -SH, H, halogen or lower alkyl;R9 is lower alkyl; andZ is selected from ethyl, and -C=C-.
2-Amino-6-bromo-4-chlorophenol Synthetic route And Reaction conditions
- 15969-10-5
2-bromo-4-chloro-6-nitro-phenol
- 179314-60-4
6-amino-2-bromo-4-chloro-phenol
| Conditions | Yield |
|---|---|
| 85.1% | |
| 64% | |
Withsulfuric acid;
at 70 ℃;
durch elektrolytische Reduktion an einer Bleikathode; |
- 876486-67-8
6,6'-dibromo-4,4'-dichloro-2,2'-azo-di-phenol
- 179314-60-4
6-amino-2-bromo-4-chloro-phenol
| Conditions | Yield |
|---|---|
- 7647-01-0,15364-23-5
hydrogenchloride
- 876486-67-8
6,6'-dibromo-4,4'-dichloro-2,2'-azo-di-phenol
- 179314-60-4
6-amino-2-bromo-4-chloro-phenol
| Conditions | Yield |
|---|---|
- 2050-14-8
2,2'-Dihydroxyazobenzene
- 179314-60-4
6-amino-2-bromo-4-chloro-phenol
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: glacial acetic acid; diluted hydrochloric acid / bis zur Bildung des Dichlorderivats, dann unter Zusatz von waessr. Kaliumbromid-Loesung 2: tin (II)-chloride; hydrochloric acid |
| Conditions | Yield |
|---|---|
| 14.19 g (99.0%) |
- 89-64-5
p-chloro-o-nitrophenol
- 179314-60-4
6-amino-2-bromo-4-chloro-phenol
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: acetic acid; bromine / 4 h / 20 °C / Cooling with ice 2: ammonium chloride; iron / ethanol; water / 1.25 h / 90 °C Withbromine;
iron;
ammonium chloride;
acetic acid;Inethanol;
water; |
- 179314-60-4
6-amino-2-bromo-4-chloro-phenol
| Conditions | Yield |
|---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 70 °C 2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 1.5 h / 105 °C 3: potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / water; 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation |
- 179314-60-4
6-amino-2-bromo-4-chloro-phenol
| Conditions | Yield |
|---|---|
Multi-step reaction with 4 steps 1: potassium carbonate / acetone / 70 °C 2: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 1.5 h / 105 °C 3: potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / water; 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation 4: hydrogen; palladium 10% on activated carbon / ethanol; water / 20 °C / 760.05 Torr Withpotassium phosphate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II);
palladium 10% on activated carbon;
hydrogen;
sodium carbonate;
potassium carbonate;In1,4-dioxane;
ethanol;
water;
acetone; |
- 179314-60-4
6-amino-2-bromo-4-chloro-phenol
| Conditions | Yield |
|---|---|
Multi-step reaction with 4 steps 1: potassium fluoride / N,N-dimethyl-formamide / 1.17 h / 70 °C 2: lithium triethylborohydride / tetrahydrofuran / 0.5 h / 20 °C 3: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation 4: potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / water; 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation Withpotassium fluoride;
potassium phosphate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II);
lithium triethylborohydride;
sodium carbonate;Intetrahydrofuran;
1,4-dioxane;
water;
N,N-dimethyl-formamide; |
- 179314-60-4
6-amino-2-bromo-4-chloro-phenol
| Conditions | Yield |
|---|---|
Multi-step reaction with 5 steps 1: potassium fluoride / N,N-dimethyl-formamide / 1.17 h / 70 °C 2: lithium triethylborohydride / tetrahydrofuran / 0.5 h / 20 °C 3: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation 4: potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II) / water; 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation 5: hydrogen; palladium 10% on activated carbon / ethanol; water / 20 °C / 760.05 Torr Withpotassium fluoride;
potassium phosphate;
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2;
chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II);
palladium 10% on activated carbon;
hydrogen;
lithium triethylborohydride;
sodium carbonate;Intetrahydrofuran;
1,4-dioxane;
ethanol;
water;
N,N-dimethyl-formamide; |
2-Amino-6-bromo-4-chlorophenol Raw materials
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(1)
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