- Melting Point:N/A
- Boiling Point:156.4 °C at 760 mmHg
- Density:1.176 g/cm3
- Flash Point:54.4 °C
- Vapor Density:N/A
- Refractive Index:1.452
- Storage Temp.:N/A
2,6-Difluoroanisole Safety information and MSDS
H226 Flammable liquid and vapour
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
·Composition/information on ingredients:
|Chemical name||Common names and synonyms||CAS number||EC number||Concentration|
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
2,6-Difluoroanisole Relevant articlesAll total 7 Articles be found
Quinolonecarboxylic acid derivatives or salts thereof
PCT No. PCT/JP97/00317 Sec. 371 Date Aug. 10, 1998 Sec. 102(e) Date Aug. 10, 1998 PCT Filed Feb. 7, 1997 PCT Pub. No. WO97/29102 PCT Pub. Date Aug. 14, 1997The present invention relates to a quinolone-carboxylic acid derivative represented by the general
Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1)
El-Ayache, Nadine C.,Li, Shih-Hon,Warnock, Mark,Lawrence, Daniel A.,Emal, Cory D.
supporting information; experimental part, p. 966 - 970 (2010/06/16)
Inactivators of plasminogen activator inhibitor-1 (PAI-1) have been identified as possible treatments for a range of conditions, including atherosclerosis, venous thrombosis, and obesity. We describe the synthesis and inhibitory activity of a novel series
HETEROCYCLICALLY SUBSTITUTED PENTANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS
Page/Page column 45-50, (2010/02/10)
The invention relates to pentanol derivatives of general formula (I), which are substituted by quinazoline, quinoxaline, cinnoline, indazole, phthalazine, naphthyridine, benzothiazole, dihydroindolone, dihydroisoindolone, benzimidazole, or indole, a method for the production thereof, and the use thereof as anti-inflammatory agents.
1-cyclopropyl-4-oxo-7-fluoro-8-methoxy -1,4-dihydro-quinoline-3-carboxylic acid synthesizing method
Paragraph 0023; 0098; 0099, (2017/01/26)
The invention discloses a synthesis method of 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method comprises the following reaction steps: reacting m-difluorophenyl with an organolithium reagent, reacting an obtained aryllithium intermediate with borate, quenching to obtain 2,6-difluorophenylboronic acid and 2,6-difluorophenylborate, reacting 2,6-difluorophenol obtained through oxidation with a methylating reagent, reacting the obtained 2,6-difluorophenylmethyl ether with the organolithium reagent, reacting the obtained corresponding aryllithium intermediate with carbon dioxide, reacting the obtained product with an acylchlorinating reagent to obtain 2,4-difluoro-3-methoxy benzoyl chloride, and performing cyclization, hydrolysis and the like to obtain the 1-cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolyl-3-carboxylic acid. The synthesis method has the advantages as follows: raw materials are easy to obtain; the yield in each step is high; the atom economy is high; the synthesis method is suitable for industrial application.
1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS
Page/Page column 59, (2010/02/11)
The invention relates to polysubstituted tetrahydronaphtalene derivatives of formula (I), to methods for the production thereof, and to their use as antiphlogistics. The substituents are defined in Claim 1.
2,6-Difluoroanisole Synthetic route And Reaction conditions
Multi-step reaction with 2 steps
1.1: propyllithium / hexane; ethylbenzene / 1 h / -50 °C / Inert atmosphere
1.2: 4 h / -60 - -30 °C / Inert atmosphere
2.1: sodium hydrogencarbonate / water; 2-methyltetrahydrofuran / 10 h / 40 - 50 °C
Multi-step reaction with 3 steps
1.1: n-butyllithium / diethyl ether; hexane / 2 h / -70 - -60 °C / Inert atmosphere
1.2: 2 h / -60 - -50 °C / Inert atmosphere
2.1: peracetic acid / tetrahydrofuran; water / 20 h / 20 - 30 °C
3.1: sodium hydrogencarbonate / water; 2-methyltetrahydrofuran / 10 h / 40 - 50 °C
2,6-Difluoroanisole Raw materials
2,6-Difluoroanisole Target Products
- Lab/Research institutionsTrading CompanyManufacturers
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
- China (Mainland)(101)United Kingdom(1)United States(1)
- 3-isopropylidene carbazic acid 3-hydroxy-3-phenylpropyl ester
- ethyl [1-(benzylsulfonyl)imidazo[1,5-a]pyridin-3-yl]acetate
- methyl 2,6-difluoro-3-(propylsulfonamido)benzoate