Phenol,3-bromo-5-fluoro-
- CAS Number:433939-27-6
- Molecular Formula:C6H4BrFO
- Molecular Weight:191
- Mol File:433939-27-6.mol
Synonyms:3-Bromo-5-fluorophenol;MolPort-001-773-363;AC-3758;ST51051707;B3063;5-Bromo-3-fluorophenol;
Physicochemical Properties
- Melting Point:42oC
- Boiling Point:231.089 °C at 760 mmHg
- Density:1.764 g/cm3
- Solubility:N/A
- Flash Point:93.56 °C
- Vapor Density:N/A
- Refractive Index:1.576
- Sensitive:N/A
- Storage Temp.:N/A
- Appearance/Colour:N/A
Phenol,3-bromo-5-fluoro- Safety information and MSDS
·Hazard identification:
| Pictogram(s) |  |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. |
| Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 3-Bromo-5-fluorophenol | 3-Bromo-5-fluorophenol | 433939-27-6 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Phenol,3-bromo-5-fluoro- Relevant articles
All total 10 Articles be found
All total 10 Articles be foundTriphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311)
Qiao, Jennifer X.,Wang, Tammy C.,Adam, Leonard P.,Chen, Alice Ye A.,Taylor, David S.,Yang, Richard Z.,Zhuang, Shaobin,Sleph, Paul G.,Li, Julia P.,Li, Danshi,Yin, Xiaohong,Chang, Ming,Chen, Xue-Qing,Shen, Hong,Li, Jianqing,Smith, Daniel,Wu, Dauh-Rurng,Leith, Leslie,Harikrishnan, Lalgudi S.,Kamau, Muthoni G.,Miller, Michael M.,Bilder, Donna,Rampulla, Richard,Li, Yi-Xin,Xu, Carrie,Lawrence, R. Michael,Poss, Michael A.,Levesque, Paul,Gordon, David A.,Huang, Christine S.,Finlay, Heather J.,Wexler, Ruth R.,Salvati, Mark E.
, p. 9010 - 9026 (2015/12/09)
Cholesteryl ester transfer protein (CETP) inhibitors raise HDL-C in animals and humans and may be antiatherosclerotic by enhancing reverse cholesterol transport (RCT). In this article, we describe the lead optimization efforts resulting in the discovery o
HETEROCYCLIC CETP INHIBITORS
-
Page/Page column 220-221, (2010/11/27)
Compounds of formula (Ia) and (Ib) wherein A, B, C and R1 are described herein.
HETEROCYCLIC CETP INHIBITORS
-
Page/Page column 176; 205, (2010/11/27)
Compounds of formula (Ia) and (Ib): wherein A, B, C and Rl are described herein, are suitable as cholesteryl ester transfer protein (CETP) inhibitors.
HETEROCYCLIC CETP INHIBITORS
-
Page/Page column 115, (2010/11/27)
Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors
Harikrishnan, Lalgudi S.,Finlay, Heather J.,Qiao, Jennifer X.,Kamau, Muthoni G.,Jiang, Ji,Wang, Tammy C.,Li, James,Cooper, Christopher B.,Poss, Michael A.,Adam, Leonard P.,Taylor, David S.,Chen, Alice Ye A.,Yin, Xiaohong,Sleph, Paul G.,Yang, Richard Z.,Sitkoff, Doree F.,Galella, Michael A.,Nirschl, David S.,Van Kirk, Katy,Miller, Arthur V.,Huang, Christine S.,Chang, Ming,Chen, Xue-Qing,Salvati, Mark E.,Wexler, Ruth R.,Lawrence, R. Michael
experimental part, p. 6162 - 6175 (2012/09/07)
A series of diphenylpyridylethanamine (DPPE) derivatives was identified exhibiting potent CETP inhibition. Replacing the labile ester functionality in the initial lead 7 generated a series of amides and ureas. Further optimization of the DPPE series for potency resulted in the discovery of cyclopentylurea 15d, which demonstrated a reduction in cholesterol ester transfer activity (48% of predose level) in hCETP/apoB-100 dual transgenic mice. The PK profile of 15d was suboptimal, and further optimization of the N-terminus resulted in the discovery of amide 20 with an improved PK profile and robust efficacy in transgenic hCETP/apoB-100 mice and in hamsters. Compound 20 demonstrated no significant changes in either mean arterial blood pressure or heart rate in telemeterized rats despite sustained high exposures.
Phenol,3-bromo-5-fluoro- Synthetic route And Reaction conditions
- 15205-66-0
2-(methylsulfonyl)ethyl alcohol
- 461-96-1
3,5-difluorobromobenzene
- 433939-27-6
3-bromo-5-fluorophenol
| Conditions | Yield |
|---|---|
- 130722-44-0
5-benzyloxy-3-fluorophenyl bromide
- 433939-27-6
3-bromo-5-fluorophenol
| Conditions | Yield |
|---|---|
5-benzyloxy-3-fluorophenyl bromide;Withaluminum (III) chloride;
N,N-dimethyl-aniline;Indichloromethane;at 0 ℃;
for 2.16667h; Withhydrogenchloride;Indichloromethane;
water; Withhydrogenchloride;
potassium hydroxide;more than 3 stages; | 92% |
| 92% | |
5-benzyloxy-3-fluorophenyl bromide;Withaluminum (III) chloride;
N,N-dimethyl-aniline;Indichloromethane;at 0 - 20 ℃;
for 2.16667h; Withhydrogenchloride;Indichloromethane;
water; | 66.6% |
- 461-96-1
3,5-difluorobromobenzene
- 433939-27-6
3-bromo-5-fluorophenol
| Conditions | Yield |
|---|---|
3,5-difluorobromobenzene;With2-(methylsulfonyl)ethyl alcohol;
potassium tert-butylate;Indimethyl sulfoxide;at 0 - 20 ℃;
for 3h; Withsodium hydroxide;Indiethyl ether;
water; | 94% |
3,5-difluorobromobenzene;Withpotassium trimethylsilonate;Indiethylene glycol dimethyl ether;at 120 ℃;
for 5h;
Inert atmosphere; | 92% |
Withpotassium trimethylsilonate;Indiethylene glycol dimethyl ether;at 120 ℃;
for 5h;
Inert atmosphere; | 92% |
3,5-difluorobromobenzene;With2-(methylsulfonyl)ethyl alcohol;
potassium tert-butylate;Indimethyl sulfoxide;at 20 ℃;
for 1h; Withhydrogenchloride;
water;Indimethyl sulfoxide; | |
3,5-difluorobromobenzene;With2-(methylsulfonyl)ethyl alcohol;
potassium tert-butylate;Indimethyl sulfoxide;at 20 ℃;
for 1h; | |
With2-(methylsulfonyl)ethyl alcohol;
potassium tert-butylate;Indimethyl sulfoxide;at 20 ℃;
for 1h;
Inert atmosphere; |
- 433939-27-6
3-bromo-5-fluorophenol
- 58479-61-1
tert-butylchlorodiphenylsilane
- 939398-84-2
(3-bromo-5-fluorophenoxy)(tert-butyl)diphenylsilane
| Conditions | Yield |
|---|---|
| 58% | |
With1H-imidazole;
at 0 - 20 ℃;
for 18h;
Inert atmosphere; | 58% |
- 433939-27-6
3-bromo-5-fluorophenol
- 354-41-6
iodo-1,1,2,2,-tetrafluoroethane
| Conditions | Yield |
|---|---|
| 87% | |
| 27.2 g |
- 433939-27-6
3-bromo-5-fluorophenol
- 107-08-4
1-iodo-propane
- 883443-32-1
1-bromo-3-fluoro-5-propoxy-benzene
| Conditions | Yield |
|---|---|
| 83.8% |
- 433939-27-6
3-bromo-5-fluorophenol
- 52334-81-3
2-chloro-5-trifluoromethylpyridine
- 1020332-11-9
2-(3-bromo-5-fluorophenoxy)-5-(trifluoromethyl)pyridine
| Conditions | Yield |
|---|---|
| 96% |
- 433939-27-6
3-bromo-5-fluorophenol
- 216755-56-5
5-fluoro-3-hydroxymethylbromobenzene
| Conditions | Yield |
|---|---|
- 433939-27-6
3-bromo-5-fluorophenol
| Conditions | Yield |
|---|---|
- 433939-27-6
3-bromo-5-fluorophenol
- 124-73-2
1,2-dibromo-1,1,2,2-tetrafluoroethane
| Conditions | Yield |
|---|---|
| 89 % Spectr. 5 % Spectr. | |
Phenol,3-bromo-5-fluoro- Raw materials
- 130722-44-0
5-benzyloxy-3-fluorophenyl bromide
- 461-96-1
3,5-difluorobromobenzene
- 15205-66-0
2-(methylsulfonyl)ethyl alcohol
Phenol,3-bromo-5-fluoro- Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(89)
United States(2)
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