4-Hydrazinobenzene-1-sulfonamide hydrochloride
- CAS Number:17852-52-7
- Molecular Formula:C6H9N3O2S*ClH
- Molecular Weight:223.683
- Mol File:17852-52-7.mol
Synonyms:Benzenesulfonamide,4-hydrazino-, monohydrochloride (9CI);Benzenesulfonamide, p-hydrazino-, monohydrochloride(8CI);(4-Sulfamoylphenyl)hydrazine hydrochloride;(p-Sulfamoylphenyl)hydrazinemonohydrochloride;4-Aminosulfonylphenylhydrazine monohydrochloride;[4-(Aminosulfonyl)phenyl]hydrazine hydrochloride;
Physicochemical Properties
- Melting Point:149-152 °C(lit.)
- Boiling Point:434.7 °C at 760 mmHg
- Density:N/A
- Solubility:N/A
- Flash Point:216.7 °C
- Vapor Density:N/A
- Refractive Index:N/A
- Sensitive:Hygroscopic
- Storage Temp.:N/A
- Appearance/Colour:white to light yellow crystal powder
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Xi4-Hydrazinobenzene-1-sulfonamide hydrochloride Safety information and MSDS
·Hazard identification:
| Pictogram(s) |   |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302 Harmful if swallowed H317 May cause an allergic skin reaction H319 Causes serious eye irritation H410 Very toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection. P273 Avoid release to the environment. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P333+P313 If skin irritation or rash occurs: Get medical advice/attention. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. P391 Collect spillage. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to ... |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 4-Hydrazinobenzene-1-sulfonamide hydrochloride | 4-Hydrazinobenzene-1-sulfonamide hydrochloride | 17852-52-7 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
4-Hydrazinobenzene-1-sulfonamide hydrochloride Relevant articles
All total 15 Articles be found
All total 15 Articles be foundSynthetic method of celecoxib intermediate P-hydrazinamide hydrochloride
-
Paragraph 0037-0044, (2020/03/17)
The method, comprises the following steps :1): preparing a sulfanilamide hydrochloric acid aqueous solution, to prepare a sodium nitrite solution ;2) to acidify, and then acidifying the resulting reaction solution to 1 with ;3) powder, activated carbon to
Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents
Kumar, Gautam,Siva Krishna, Vagolu,Sriram, Dharmarajan,Jachak, Sanjay M.
, (2020/06/05)
Pyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole–coumarin chalcones and pyrazole–quinoline chalcones were synthesized using multiple-step reactions. All the synthesized compounds were well c
HFO-1234yf as a CF3-Building Block: Synthesis and Chemistry of CF3-Ynones
Murray, Ben J.,Marsh, Thomas G. F.,Yufit, Dmitri S.,Fox, Mark A.,Harsanyi, Antal,Boulton, Lee T.,Sandford, Graham
supporting information, p. 6236 - 6244 (2020/09/15)
Reaction of low cost, readily available 4th generation refrigerant gas 2,3,3,3-tetrafluoropropene (HFO-1234yf) with lithium diisopropylamide (LDA) leads to formation of lithium 3,3,3-trifluoropropynide, addition of which to a range of aldehydes formed CF3-alkynyl alcohol derivatives on multigram scale, which were oxidised using Dess–Martin periodinane (DMP) to give substituted CF3-ynones with minimal purification required. Michael-type additions of alcohol and amine nucleophiles to CF3-ynones are rapid and selective, affording a range of CF3-enone ethers and enaminones in excellent yields with high stereoselectivity for the Z-isomer. By analogous reactions with difunctional nucleophiles, a wide range of CF3-substituted pharmaceutically relevant heterocyclic structures can be accessed, exemplified in the simple synthesis of the anti-arthritis drug celecoxib from HFO-1234yf in just three steps.
CONTINUOUS PROCESSES FOR THE MANUFACTURE OF CELOCOXIB
-
Page/Page column 14, (2019/04/26)
A continuous process for the manufacture of celecoxib includes reacting a stream of a first solution of 4'-methylacetophenone in a first organic solvent and a stream of a second solution of ethyl trifluoroacetate in a second organic solvent in a first reactor in the presence of a base at a first reaction temperature of between 45°C and 90°C and at a first reaction pressure to form 4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione. The first reaction pressure prevents boiling inside the first reactor. A stream of a first reactor product from the first reactor is continuously withdrawn, the first reactor product including a solution of 4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione in the first organic solvent and the second organic solvent. A stream of the first reactor product and a stream of a third solution of (4-Sulfamoylphenyl)hydrazine hydrochloride in a third organic solvent are reacted in a second reactor at a second reaction temperature of between 80°C and 110°C and at a second reaction ressure to form celecoxib. The second reaction pressure prevents boiling inside the second reactor. A stream of a second reactor product is continuously withdrawn from the second reactor, the second reactor product including a solution of celecoxib in organic solvent.
An Integrated Continuous Flow Micro-Total Ultrafast Process System (μ-TUFPS) for the Synthesis of Celecoxib and Other Cyclooxygenase Inhibitors
Sthalam, Vinay Kumar,Singh, Ajay K.,Pabbaraja, Srihari
supporting information, p. 1892 - 1899 (2019/10/11)
Integrated continuous manufacturing has emerged as a promising device for the rapid manufacturing of active pharmaceutical ingredients (APIs). We herein report a newly designed continuous flow micro-total process system platform for the rapid manufacturing of celecoxib, a selective nonsteroidal anti-inflammatory drug. This approach has been proven generally for the synthesis of several alkyl and aryl substituted pyrazoles. In order to minimize the tedious work-up process of potential reaction intermediates/products, we have developed a continuous flow extraction and separation platform to carry out the entire reaction sequence resulting in a short residence time with good yield. The present process was further extended to gram-scale synthesis of the COX-2-related API, viz. celecoxib, in the continuous flow process.
4-Hydrazinobenzene-1-sulfonamide hydrochloride Synthetic route And Reaction conditions
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
- 169590-42-5,194044-54-7
4-[5-(4-(methyl)phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide
| Conditions | Yield |
|---|---|
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
| Conditions | Yield |
|---|---|
- 63-74-1
sulfanilamide
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
| Conditions | Yield |
|---|---|
| 87.9% | |
Withsodium nitrite;
at -5 ℃;
for 0.25h; Withhydrogenchloride;
tin(ll) chloride;
at -20 - -5 ℃;
Further stages.; | 86% |
| 83% | |
| 75% | |
| 74.1% | |
| 74.1% | |
| 71% | |
| 59% | |
| 55% | |
Withhydrogenchloride;
tin(ll) chloride;
at -15 ℃;
for 3h; | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water / 80 °C 2: sodium hydrogensulfite 3: hydrogenchloride / Reflux |
- 35282-78-1
4-(aminosulphonyl)benzenediazonium chloride
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: sodium hydrogensulfite 2: hydrogenchloride / Reflux |
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
| Conditions | Yield |
|---|---|
Withhydrogenchloride;Reflux; |
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
- 5706-12-7,17434-21-8,17598-66-2
2-benzylidine-1-indanone
- 263903-61-3
4-(3-phenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl benzenesulfonamide
| Conditions | Yield |
|---|---|
- 17434-24-1,17434-25-2,5706-14-9
2-(4-methoxybenzylidene)-2,3-dihydro-1H-inden-1-one
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
| Conditions | Yield |
|---|---|
- 5706-13-8
2-(2-methoxybenzylidene)-1-indanone
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
| Conditions | Yield |
|---|---|
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
- 141247-28-1
2-(3,4,5-trimethoxybenzylidene)-2,3-dihydro-1H-inden-1-one
| Conditions | Yield |
|---|---|
- 182689-77-6
2-(4-fluorobenzylidene)-2,3-dihydroinden-1-one
- 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride
| Conditions | Yield |
|---|---|
4-Hydrazinobenzene-1-sulfonamide hydrochloride Raw materials
4-Hydrazinobenzene-1-sulfonamide hydrochloride Target Products
- 251443-35-3
1-(4-aminosulphonylphenyl)-4,5-dihydro-5-(3-methyl-4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole
- 111607-53-5
4-{N'-[(E)-1-Phenyl-3-p-tolyl-prop-2-en-(E)-ylidene]-hydrazino}-benzenesulfonamide
- 111607-54-6
4-{N'-[(E)-3-(4-Chloro-phenyl)-1-phenyl-prop-2-en-(E)-ylidene]-hydrazino}-benzenesulfonamide
- 123517-72-6
4-{N'-[(E)-1-(4-Bromo-phenyl)-3-phenyl-prop-2-en-(E)-ylidene]-hydrazino}-benzenesulfonamide
- 122259-17-0
4-(3-(4-bromophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
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Country :
China (Mainland)(303)
India(6)
United Kingdom(4)
United States(4)
Japan(1)
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