Benzeneacetonitrile,4-bromo-a,a-dimethyl-
- CAS Number:101184-73-0
- Molecular Formula:C10H10BrN
- Molecular Weight:224.1
- Mol File:101184-73-0.mol
Synonyms:1-Bromo-4-(1-cyano-1-methylethyl)benzene;2-(4-Bromophenyl)-2,2-dimethylacetonitrile;2-(4-Bromophenyl)-2-methylpropanenitrile;2-(4-Bromophenyl)-2-methylpropionitrile;4-Bromo-a,a-dimethylbenzeneacetonitrile;
Physicochemical Properties
- Melting Point:110-113 °C
- Boiling Point:299.8 °C at 760 mmHg
- Density:1.352g/cm3
- Solubility:N/A
- Flash Point:135.1 °C
- Vapor Density:N/A
- Refractive Index:1.543
- Sensitive:N/A
- Storage Temp.:Keep Cold
- Appearance/Colour:N/A
XiBenzeneacetonitrile,4-bromo-a,a-dimethyl- Safety information and MSDS
·Hazard identification:
| Pictogram(s) |   |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H302+H332 Harmful if swallowed or if inhaled H411 Toxic to aquatic life with long lasting effects |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. |
| Response | P301+P312 IF SWALLOWED: Call a POISON CENTER/doctor/…if you feel unwell. P330 Rinse mouth. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P312 Call a POISON CENTER/doctor/…if you feel unwell. P391 Collect spillage. |
| Storage | none |
| Disposal | P501 Dispose of contents/container to ... |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-(4-Bromophenyl)-2-Methylpropanenitrile | 2-(4-Bromophenyl)-2-Methylpropanenitrile | 101184-73-0 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Benzeneacetonitrile,4-bromo-a,a-dimethyl- Relevant articles
All total 32 Articles be found
All total 32 Articles be foundProtein arginine methyltransferase 5 (PRMT5) inhibitor, pharmaceutical products thereof, and methods thereof
-
Paragraph 0120-0124, (2020/11/05)
The present invention provides a PRMT5 inhibitor of formula (I); R1 is a non-hydrogen monovalent group; W is a direct bond or-NH-; T, U and V are independently from each other selected from C and N; R2 is H or halogen; m is 1 or 2; X is carbon, nitrogen or oxygen; Y is C or N; Z is a direct bond or carbon; R3 is H, a non-hydrogen monovalent group, an oxo group, a divalent spiro-forming group or adivalent bridge-forming group; and n is 1 or 2, and represents a single or double bond. The present invention also provides pharmaceutical products comprising the PRMT5 inhibitor and use thereof in the treatment of proliferative disorders such as cancer, metabolic disorders, hematological disorders, autoimmune diseases and inflammatory diseases.
Palladium-Catalyzed Distal m-C-H Functionalization of Arylacetic Acid Derivatives
Srinivas, Dasari,Satyanarayana, Gedu
supporting information, p. 7353 - 7358 (2021/10/01)
Herein, we present m-C-H olefination on derivatives of phenylacetic acids by tethering with a simple nitrile-based template through palladium catalysis. Notably, the versatility of the method is evaluated with a wide range of phenylacetic acid derivatives for obtaining the meta-olefination products in fair to excellent yields with outstanding selectivities under mild conditions. Significantly, the present strategy is successfully exemplified for the synthesis of drugs/natural product analogues (naproxen, ibuprofen, paracetamol, and cholesterol).
MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
-
Paragraph 00704, (2018/09/12)
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5), PHARMACEUTICAL PRODUCTS THEREOF, AND METHODS THEREOF
-
Paragraph 092; 093, (2019/10/01)
The present invention provides PRMT5 inhibitors of Formula (I), wherein R1 is a non-hydrogen monovalent group; W is a direct bond or -NH-; T, U, and V are independently of each other selected from C and N; R2 is H or a halo; m is 1 or 2; X is a carbon, a nitrogen, or an oxygen; Y is C or N; Z is a direct bond or a carbon; R3 is H, a non-hydrogen monovalent group, an oxo group, a bivalent spiro ring-forming group, or a bivalent bridge-forming group; n is 1 or 2; and Formula (II) stands for a single bond or a double bond. Pharmaceutical products comprising the PRMT5 inhibitors and use thereof in treating proliferative disorders such as cancer, metabolic disorders, blood disorders, autoimmune diseases, and inflammatory diseases are also provided.
Cobalt-catalyzed C[sbnd]H activation/C[sbnd]O formation: Synthesis of benzofuranones
Hajipour, Abdol R.,Khorsandi, Zahra
, (2019/11/26)
Herein, C[sbnd]H activation/C[sbnd]O formation reaction using novel cobalt catalytic system is reported. This reaction was given benzofuranones in moderate to excellent yields at room-temperature under air reaction conditions. The introduced strategy is efficient and low-cost method to synthesized benzofuranones from α,α-disubstitution acetic acid.
Benzeneacetonitrile,4-bromo-a,a-dimethyl- Synthetic route And Reaction conditions
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
| Conditions | Yield |
|---|---|
| 87% |
- 16532-79-9
4-Bromophenylacetonitrile
- 74-88-4
methyl iodide
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
| Conditions | Yield |
|---|---|
| 100% | |
| 99% | |
| 96% | |
| 96% | |
| 96% | |
| 96% | |
| 96% | |
| 95% | |
| 91% | |
| 91% | |
| 87.5% | |
| 80% | |
4-Bromophenylacetonitrile;Withsodium hydride;InN,N-dimethyl-formamide;
mineral oil;at 0 ℃;
for 0.25h; | 78% |
4-Bromophenylacetonitrile;Withsodium hydride;InN,N-dimethyl-formamide;
mineral oil;at 0 ℃;
for 0.333333h; | 78% |
4-Bromophenylacetonitrile;Withpotassium tert-butylate;Intetrahydrofuran;at -40 ℃;
for 0.25h;
Inert atmosphere; | 76% |
| 75% | |
| 70% | |
| 42% | |
WithKOBu-t;Intetrahydrofuran; | |
| 5 g | |
4-Bromophenylacetonitrile;Withpotassium hexamethylsilazane;Intetrahydrofuran;at 0 - 3 ℃;
for 0.666667h; | 13 g |
4-Bromophenylacetonitrile;Withlithium diisopropyl amide;Intetrahydrofuran;at 45 ℃;
for 1h;
Inert atmosphere; |
- 74-88-4
methyl iodide
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
| Conditions | Yield |
|---|---|
| 96% |
- 16532-79-9
4-Bromophenylacetonitrile
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
| Conditions | Yield |
|---|---|
4-Bromophenylacetonitrile;Withsodium hydride;InN,N-dimethyl-formamide;
mineral oil;at 0 ℃;
Inert atmosphere; | |
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
| Conditions | Yield |
|---|---|
- 110-00-9
furan
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
| Conditions | Yield |
|---|---|
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
- 264602-70-2
2-(4-bromophenyl)-2-methylpropan-1-amine
| Conditions | Yield |
|---|---|
| 0.75 g | |
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
- 32454-16-3
2-(4-bromophenyl)-2-methyl-propionaldehyde
| Conditions | Yield |
|---|---|
2-(4-bromophenyl)-2-methylpropanenitrile;Withdiisobutylaluminium hydride;Indichloromethane;at -78 ℃;
for 1.5h; | |
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
- 32454-35-6
2-(4-bromophenyl)-2-methylpropionic acid
| Conditions | Yield |
|---|---|
| 100% | |
| 99% | |
| 5.3 g | |
- 101184-73-0
2-(4-bromophenyl)-2-methylpropanenitrile
- 927-74-2
3-Butyn-1-ol
- 252022-33-6
2-[4-(4-Hydroxy-1-butynyl)phenyl]isobutyronitrile
| Conditions | Yield |
|---|---|
| 85% |
Benzeneacetonitrile,4-bromo-a,a-dimethyl- Raw materials
Benzeneacetonitrile,4-bromo-a,a-dimethyl- Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(43)
United States(2)
Recommended products
- 2-{[2-oxo-1-(2-oxo-2,3-dihydro-1H-benzoimidazol-5-ylcarbamoyl)-propylidene]-hydrazino}-benzoic acid
- m-fluorophenyl benzoate
- (3R,6'RS)-3-hydroxy-β,ε-caroten-3'-one
- 1,2,3-trimethyl-[1,3,2]diazaborolidine
- 2-Isopropenyl-5-methylene-cyclohexanol
- 3-(2-propenyl)-3,5,5-trimethylcyclohexanone
- 1-(phenylthio)-1-(trimethylsilyl)cyclohexane
- 5,7-dibenzyloxy-2-styrylchromone
- (R)-N-(2-(1-benzylpyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
- 5-(3-nitrophenyl)pent-4-ynoic acid methyl ester
- 2-(2-phenyl-1,2-dihydronaphtho[2,1-b]furan-2-yl)acetic acid
- 2-(4-methoxybenzyl)benzonitrile
- 8-oxo-7-phenylacetylamino-3-(toluene-4-sulfonyloxy)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxybenzyl ester
- 4-{(E)-2-[4-(diethylamino)phenyl]ethenyl}-1-methylpyridinium iodide
- 1,1-bis-(4-fluorophenyl)-ethylene oxide
Please post your buying leads,so that our qualified suppliers will soon contact you!
*Required Fields
