2-Propenoic acid,2-fluoro-
- CAS Number:430-99-9
- Molecular Formula:C3H3FO2
- Molecular Weight:90.054
- Mol File:430-99-9.mol
Synonyms:Acrylicacid, 2-fluoro- (8CI);2-Fluoroacrylic acid;
Physicochemical Properties
- Melting Point:51.5 °C
- Boiling Point:181.3 °C at 760 mmHg
- Density:1.233 g/cm3
- Solubility:N/A
- Flash Point:63.5 °C
- Vapor Density:N/A
- Refractive Index:1.388
- Sensitive:N/A
- Storage Temp.:N/A
- Appearance/Colour:N/A
Xi2-Propenoic acid,2-fluoro- Safety information and MSDS
·Hazard identification:
| Pictogram(s) |  |
|---|---|
| Signal word | Danger |
| Hazard statement(s) | H314 Causes severe skin burns and eye damage |
| Precautionary statement(s) | |
| Prevention | P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. |
| Response | P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P310 Immediately call a POISON CENTER/doctor/… P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to ... |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-Fluoroacrylic acid | 2-Fluoroacrylic acid | 430-99-9 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
2-Propenoic acid,2-fluoro- Relevant articles
All total 4 Articles be found
All total 4 Articles be foundSYNTHESIS OF 2-FLUOROPROPENOIC ACID DERIVATIVES
Tolman, Vladimir,Spronglova, Pavla
, p. 319 - 326 (2007/10/02)
A method is described for the synthesis of 2-fluoropropenoic acid esters, amides, and nitrile from the corresponding derivatives of 2-fluoro-3-(4-toluenesulfonyloxy)propanoic acid by heating with potassium phtalimide in vacuo.The free acid Ia and its chloride have also been synthetized.The reactivity of esters and nitrile of acid Ia has been verified by the Michael addition of diethyl acetamidomalonate to these compounds.
PRODUCTION METHOD FOR ALPHA-FLUORO ACRYLIC ACID ESTERS
-
Paragraph 0149; 0150, (2016/11/17)
An object of the present invention is to provide a process for producing α-fluoroacrylic acid esters at a high starting material conversion and a high yield. The present invention provides, as a means to achieve the object, a process for producing a compound represented by formula (1): wherein R2 and R2 are the same or different and each represent alkyl, fluoroalkyl, aryl optionally substituted with at least one substituent, halogen, or hydrogen; and R3 represents alkyl, fluoroalkyl, or aryl optionally substituted with at least one substituent, the process comprising step A ofreacting a compound represented by formula (2): wherein the symbols are as defined above, with carbon monoxide and an alcohol represented by formula (3): [in-line-formulae]R3—OH ??(3)[/in-line-formulae]wherein the symbol is as defined above, in the presence of a transition metal complex catalyst containing at least one bidentate phosphine ligand and a base to thereby obtain the compound represented by formula (1).
METHOD FOR PRODUCING alpha-FLUOROACRYLIC ACID
-
Paragraph 0307-0308; 0313-0314; 0326-0327, (2021/09/03)
An object of the present invention is to provide a novel method for producing an α-fluoroacrylic acid ester compound. This problem is solved by a method for producing a compound represented by formula (1), wherein R1 and R2 are identical or different, and each represents an alkyl group or the like; and R3 is an alkyl group or the like, the method comprising step A of reacting a compound represented by formula (2) with R3—OH (3) and carbon monoxide in the presence of palladium, a double bond-containing compound (α), a diphosphine compound (β), and a base, to obtain the compound represented by formula (1) above.
Low-temperature 19F NMR spectroscopy of 1-fluoro-1-lithioethenes - Stability, shifts and unexpected coupling constants
Kvicala, Jaroslav,Hrabal, Richard,Czernek, Jiri,Bartosova, Ivana,Paleta, Oldrich,Pelter, Andrew
, p. 211 - 218 (2007/10/03)
Half-lives and fluorine atom shifts of stabilized 1-fluoro-l-lithioethenes bearing hydrogen, fluorine, phenyl, and/or dimethylphenylsilyl groups in the β-positions have been determined by a low-temperature 19F NMR spectroscopy. Some 1-fluoro-1-lithioethenes displayed an exceptionally low value of the trans-3JFF coupling constant. Stereoselectivity of carbenoid formation, as well as an effect of configuration on the stability is discussed.
2-Propenoic acid,2-fluoro- Synthetic route And Reaction conditions
| Conditions | Yield |
|---|---|
Withsodium hydroxide;Inethanol;
water; | 39% |
Withsodium hydroxide;
at 20 ℃; | 0.30 g |
- 67-56-1
methanol
- 420-25-7
1-bromo-1-fluoroethylene
- 201230-82-2
carbon monoxide
- 430-99-9
2-fluoroacrylic acid
- 2343-89-7
methyl 2-fluoroprop-2-enoate
| Conditions | Yield |
|---|---|
Withdichloro[bis(2-(diphenylphosphino)phenyl)ether]palladium(ll);
triethylamine;
at 100 ℃;
for 13h;
under 7500.75 Torr;
Autoclave; | 70.9% 14.1% |
- 67-56-1
methanol
- 2317-91-1
1-chloro-1-fluoroethane
- 201230-82-2
carbon monoxide
- 430-99-9
2-fluoroacrylic acid
- 2343-89-7
methyl 2-fluoroprop-2-enoate
| Conditions | Yield |
|---|---|
With1,4-bis(dicyclohexylphosphino)butane;
palladium(II) acetylacetonate;
triethylamine;
at 85 ℃;
for 26h;
Temperature;
Autoclave; |
- 430-99-9
2-fluoroacrylic acid
| Conditions | Yield |
|---|---|
2-fluoroacrylic acid;
(S)-(4-(4-amino-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl)(phenyl)methanone;Withtriethylamine;Indichloromethane;at 20 ℃;
for 0.5h;
Inert atmosphere;
Cooling with ice; With2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide;Indichloromethane;
ethyl acetate;at 20 ℃;
for 2h;
Inert atmosphere;
Cooling with ice; |
- 430-99-9
2-fluoroacrylic acid
| Conditions | Yield |
|---|---|
With2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide;
triethylamine;Indichloromethane;
ethyl acetate;at 0 - 20 ℃;
for 2h; |
- 430-99-9
2-fluoroacrylic acid
| Conditions | Yield |
|---|---|
With2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide;
triethylamine;Indichloromethane;
ethyl acetate;at 0 - 20 ℃;
for 2h; |
- 897019-59-9
3-(benzyloxy)azetidine hydrochloride
- 430-99-9
2-fluoroacrylic acid
| Conditions | Yield |
|---|---|
| 43% |
| Conditions | Yield |
|---|---|
- 430-99-9
2-fluoroacrylic acid
| Conditions | Yield |
|---|---|
| 70% |
| Conditions | Yield |
|---|---|
Withthionyl chloride;
at 5 - 35 ℃;
for 2h;
Concentration;
Reagent/catalyst; | 93% |
Withsulfuric acid; |
2-Propenoic acid,2-fluoro- Raw materials
- 760-80-5
ethyl 2-fluoroacrylate
- 67-56-1
methanol
- 420-25-7
1-bromo-1-fluoroethylene
- 201230-82-2
carbon monoxide
- 2317-91-1
1-chloro-1-fluoroethane
2-Propenoic acid,2-fluoro- Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(60)
United Kingdom(1)
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