Benzoic acid,4-cyano-2,6-difluoro-
- CAS Number:181073-82-5
- Molecular Formula:C8H3F2NO2
- Molecular Weight:183.114
- Mol File:181073-82-5.mol
Synonyms:4-Cyano-2,6-difluorobenzoicacid;
Physicochemical Properties
- Melting Point:N/A
- Boiling Point:303.895 °C at 760 mmHg
- Density:1.518 g/cm3
- Solubility:N/A
- Flash Point:137.591 °C
- Vapor Density:N/A
- Refractive Index:1.54
- Sensitive:N/A
- Storage Temp.:N/A
- Appearance/Colour:N/A
Benzoic acid,4-cyano-2,6-difluoro- Safety information and MSDS
·Hazard identification:
| Pictogram(s) | no data available |
|---|---|
| Signal word | no data available |
| Hazard statement(s) | no data available |
| Precautionary statement(s) | |
| Prevention | no data available |
| Response | no data available |
| Storage | no data available |
| Disposal | no data available |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 4-CYANO-2,6-DIFLUOROBENZOIC ACID | 4-CYANO-2,6-DIFLUOROBENZOIC ACID | 181073-82-5 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Benzoic acid,4-cyano-2,6-difluoro- Relevant articles
All total 7 Articles be found
All total 7 Articles be foundTHIAZOLE DERIVATIVES FOR THE TREATMENT OF ANIMAL TRYPANOSOMIASIS
-
Page/Page column 59; 60, (2016/10/04)
The present invention relates to a novel class of compounds of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, X and Y are as defined herein, to their use in human and veterinary medicine, and in the treatment of animal trypanosomiasis in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.
NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
-
Page/Page column 114, (2013/03/26)
The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, (I) in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or metabolic syndrome via inhibition of HDAC4.
MACROCYCLES AS FACTOR XIA INHIBITORS
-
Page/Page column 154, (2011/09/15)
The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
-
, (2014/06/23)
The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A′ B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.
HETEROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
-
, (2012/12/13)
The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A' B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.
Benzoic acid,4-cyano-2,6-difluoro- Synthetic route And Reaction conditions
- 124-38-9,18923-20-1
carbon dioxide
- 64248-63-1
3,5-difluorobenzonitrile
- 181073-82-5
4-cyano-2,6-difluorobenzoic acid
| Conditions | Yield |
|---|---|
| 65.3% | |
Withhydrogenchloride;Inwater; | 55.6% |
- 467442-15-5
3,5-difluoro-4-formylbenzonitrile
- 181073-82-5
4-cyano-2,6-difluorobenzoic acid
| Conditions | Yield |
|---|---|
Withsodium chlorite;
potassium dihydrogenphosphate;
aminosulfonic acid;Inwater;
dimethyl sulfoxide;at 20 ℃;
for 1h; | 91.32% |
| 91.32% | |
- 64248-63-1
3,5-difluorobenzonitrile
- 181073-82-5
4-cyano-2,6-difluorobenzoic acid
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C 1.2: 0.75 h 2.1: aminosulfonic acid; potassium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide / 1 h / 20 °C | |
Multi-step reaction with 2 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h 1.2: 45 h 2.1: potassium dihydrogenphosphate; sodium chlorite / water; dimethyl sulfoxide / 1 h / 20 °C |
- 181073-82-5
4-cyano-2,6-difluorobenzoic acid
- 1355664-52-6
4-cyano-2,6-difluorobenzoyl chloride
| Conditions | Yield |
|---|---|
Withthionyl chloride;
for 3h;
Reflux; | 91.18% |
Withthionyl chloride;
for 3h;
Reflux; | 91.18% |
- 181073-82-5
4-cyano-2,6-difluorobenzoic acid
- 1418293-07-8
(R)-N-(1-(dimethylamino)propan-2-yl)-2,6-difluoro-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
| Conditions | Yield |
|---|---|
Multi-step reaction with 3 steps 1: potassium carbonate; hydroxylamine hydrochloride; 8-quinolinol / ethanol / 4 h / Reflux 2: tetrahydrofuran / 3.08 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 3 h / 75 °C |
- 181073-82-5
4-cyano-2,6-difluorobenzoic acid
- 1418293-50-1
2,6-difluoro-4-(N'-hydroxycarbamimidoyl)benzoic acid
| Conditions | Yield |
|---|---|
| 10.22% |
- 181073-82-5
4-cyano-2,6-difluorobenzoic acid
- 1418293-51-2
2,6-difluoro-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzoic acid
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: potassium carbonate; hydroxylamine hydrochloride; 8-quinolinol / ethanol / 4 h / Reflux 2: tetrahydrofuran / 3.08 h / 20 °C |
- 181073-82-5
4-cyano-2,6-difluorobenzoic acid
| Conditions | Yield |
|---|---|
| Conditions | Yield |
|---|---|
Withthionyl chloride;
at 0 ℃;
for 17h;
Reflux; |
- 181073-82-5
4-cyano-2,6-difluorobenzoic acid
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1.1: N-ethyl-N,N-diisopropylamine / 20 °C 1.2: 20 °C 2.1: tetrahydrofuran; diethyl ether / 4.83 h / 0 - 20 °C |
Benzoic acid,4-cyano-2,6-difluoro- Raw materials
- 124-38-9
carbon dioxide
- 64248-63-1
3,5-difluorobenzonitrile
- 467442-15-5
3,5-difluoro-4-formylbenzonitrile
Benzoic acid,4-cyano-2,6-difluoro- Target Products
- 181073-83-6
[6-(4-cyano-2,6-difluoro-benzoylamino)-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester
- 267242-16-0
[6-(4-carbamimidoyl-2,6-difluoro-benzoylamino)-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl]-acetic acid ethyl ester
- 267242-12-6
{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-2,6-difluoro-benzoylamino]-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl}-acetic acid ethyl ester
- 1270977-92-8
4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}piperazin-1-yl)carbonyl]-3,5-difluorobenzonitrile
- 1270977-93-9
4-[(4-{3-cyano-2-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propyl}piperazin-1-yl)carbonyl]-3,5-difluorobenzonitrile phosphate
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(33)
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