Benzenamine,4-methyl-N,N-diphenyl-
- CAS Number:4316-53-4
- Molecular Formula:C19H17N
- Molecular Weight:259.351
- Mol File:4316-53-4.mol
Synonyms:(4-Methylphenyl)diphenylamine;4-Methyl-N,N-diphenylaniline;4-Methyl-N,N-diphenylbenzenamine;N-(4-Methylphenyl)-N,N-diphenylamine;
Physicochemical Properties
- Melting Point:67 °C
- Boiling Point:393.8 °C at 760 mmHg
- Density:1.095 g/cm3
- Solubility:N/A
- Flash Point:171.8 °C
- Vapor Density:N/A
- Refractive Index:1.636
- Sensitive:N/A
- Storage Temp.:N/A
- Appearance/Colour:N/A
Benzenamine,4-methyl-N,N-diphenyl- Safety information and MSDS
·Hazard identification:
| Pictogram(s) |  |
|---|---|
| Signal word | Warning |
| Hazard statement(s) | H315 Causes skin irritation H319 Causes serious eye irritation |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. |
| Response | P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P313 If skin irritation occurs: Get medical advice/attention. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313 If eye irritation persists: Get medical advice/attention. |
| Storage | none |
| Disposal | none |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 4-Methyltriphenylamine | 4-Methyltriphenylamine | 4316-53-4 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Benzenamine,4-methyl-N,N-diphenyl- Relevant articles
All total 85 Articles be found
All total 85 Articles be foundTransition-Metal-Free Diarylation of Isocyanates with Arynes
Jang, Woo Cheol,Hwang, Dong Wook,Seo, Jeong Hoon,Ko, Haye Min
supporting information, (2019/08/30)
A facile method for the transition-metal-free diarylation of isocyanates with arynes in the presence of cesium fluoride has been developed, which affords functionalized diaryl amines in moderate to excellent yields. This reaction has good functional group tolerance and provides excellent regioselectivity by utilizing a methoxy-substituted aryne precursor.
PHOSPHINE COMPOUND, CROSSLINKED COMPOSITION, AND MANUFACTURING METHOD OF AROMATIC AMINE COMPOUND
-
Paragraph 0044-0046; 0047-0048, (2019/12/25)
PROBLEM TO BE SOLVED: To provide a phosphine compound capable of constituting a transition metal complex excellent in reaction speed and selectivity as a catalyst. SOLUTION: There is provided a phosphine compound represented by the formula (I). In the formula Ar represents each independently an aryl group which may be substituted, R1 represents each independently a linear, branched or cyclic alkyl group, R2 represents each independently a linear, branched or cyclic alkyl group, alkoxy group or aryl group which may be substituted, or neighboring 2 R2 are bound each other to form a ring, and n represents an integer of 0 to 4. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
DIARYL AMINE COMPOUND AND METHOD FOR PRODUCING THE SAME
-
Paragraph 0218; 0235-0237, (2021/03/16)
The present invention relates to a process for the preparation of diaryl amine compounds. A compound represented by chemical formula 1, a compound represented by chemical formula 2, and a synthetic reagent in a solvent, the synthetic reagent being CsF, KF, 18 - crown -6, K. 2 CO3, [TBAT] The present invention relates to a process for the preparation of diaryl amine compounds comprising a material selected from the group consisting of a (tetrabutylammonium difluorotriphenylsilicate), TBAF (tetrabutylammonium fluoride) and combinations thereof. Chemical Formula 1. Chemical Formula 2. The diaryl amine compound can be synthesized under the absence of a transition metal to be used to synthesize diaryl amine compounds having various substituents.
Design of Benzimidazolyl Phosphines Bearing AlterableP,OorP,N-Coordination: Synthesis, Characterization, and Insights into Their Reactivity
Wong, Shun Man,Choy, Pui Ying,Zhao, Qingyang,Yuen, On Ying,Yeung, Chung Chiu,So, Chau Ming,Kwong, Fuk Yee
supporting information, p. 2265 - 2271 (2021/05/05)
A new series of hemilabile benzimidazolyl phosphines is reported. Entities in this ligand family can be easily assembled and prepared on a large scale via a simple one-pot procedure. X-ray crystallographic analyses show that the Pd metal center can coordinate in different fashions, where it relies on the size of the ?PR2group. With the same ligand scaffold, the ligand having a ?PCy2moiety displays better efficiency in expediting aromatic C-C bond-coupling reactions, while the ligand associated with a ?P-t-Bu2group, in contrast, promotes C-N bond-forming reactions.
A Tetraarylpyrrole-Based Phosphine Ligand for the Palladium-Catalyzed Amination of Aryl Chlorides
Sai, Masahiro
supporting information, p. 5422 - 5428 (2021/10/08)
A tetraarylpyrrole-based phosphine ligand L1 in combination with Pd(dba)2 provided a catalyst for the Buchwald-Hartwig amination reaction. A variety of amines were rapidly coupled with aryl chlorides at a Pd loading of 0.5 mol%. The selective monoarylation of aliphatic primary amines was achieved in the presence of 0.8 equiv. water. Comparison experiments were also conducted, which revealed that the catalytic activity of L1 is superior to representative phosphine ligands in the Pd-catalyzed C?N coupling of various amines. (Figure presented.).
Benzenamine,4-methyl-N,N-diphenyl- Synthetic route And Reaction conditions
- 591-50-4
iodobenzene
- 620-84-8
4-methyldiphenylamine
- 4316-53-4
diphenyl(p-tolyl)amine
- 501-60-0
(E)-4,4'-dimethylazobenzene
| Conditions | Yield |
|---|---|
| 14% 4% 73% |
- 591-50-4
iodobenzene
- 624-31-7
4-tolyl iodide
- 122-39-4
diphenylamine
- 603-34-9
N,N-diphenylaminobenzene
- 4316-53-4
diphenyl(p-tolyl)amine
| Conditions | Yield |
|---|---|
potassium hydroxide;
copper;at 160 ℃;
Rate constant;
Mechanism;
competitive reaction, var. catalysts; |
- 591-17-3
meta-bromotoluene
- 122-39-4
diphenylamine
- 4316-53-4
diphenyl(p-tolyl)amine
- 4316-54-5
N,N-diphenyl-m-toluidine
- 4316-55-6
2-methyl-N,N-diphenylaniline
| Conditions | Yield |
|---|---|
Withpotassium hydroxide;PEGDM-400;Intoluene;at 161 - 163 ℃;
for 8h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
- 106-38-7
para-bromotoluene
- 122-39-4
diphenylamine
- 4316-53-4
diphenyl(p-tolyl)amine
- 4316-54-5
N,N-diphenyl-m-toluidine
| Conditions | Yield |
|---|---|
Withpotassium hydroxide;PEGDM-400;Intoluene;at 165 ℃;
for 8h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
Withiron(III) oxide;
potassium tert-butylate;Indimethyl sulfoxide;at 130 ℃;
for 36h;
regioselective reaction; |
| Conditions | Yield |
|---|---|
Withcopper;
at 195 ℃; |
- 4316-53-4
diphenyl(p-tolyl)amine
| Conditions | Yield |
|---|---|
With1, 3-(di(dicyclohexyl)phosphinyl-2-(2’-N, N-dimethylamine)phenyl)indene;
bis(dibenzylideneacetone)-palladium(0);
sodium t-butanolate;In1,2-dimethoxyethane;at 120 ℃;
for 12h;
Reagent/catalyst;
Sealed tube; | 75% |
Withbis(acetylacetonato)palladium(II);
tripotassium phosphate "n" hydrate;
dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine;Inn-heptane;at 130 ℃;
for 24h;
Inert atmosphere; | 69% |
| 40% | |
| Conditions | Yield |
|---|---|
| 95% | |
Withpotassium tert-butylate;
1,2-bis(2,6-diisopropylphenylimino)ethane;copper(l) iodide;Intoluene;at 120 ℃;
for 48h; | 82% |
| 65% |
Benzenamine,4-methyl-N,N-diphenyl- Raw materials
- 624-31-7
4-tolyl iodide
- 122-39-4
diphenylamine
- 591-50-4
iodobenzene
- 591-17-3
meta-bromotoluene
- 106-38-7
para-bromotoluene
Benzenamine,4-methyl-N,N-diphenyl- Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(74)
United Kingdom(2)
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