Acetamide, N-[1-(4-bromophenyl)ethenyl]-
- CAS Number:177750-12-8
- Molecular Formula:C10H10BrNO
- Molecular Weight:240.099
- Mol File:177750-12-8.mol
Synonyms:
Physicochemical Properties
- Melting Point:N/A
- Boiling Point:N/A
- Density:N/A
- Solubility:N/A
- Flash Point:N/A
- Vapor Density:N/A
- Refractive Index:N/A
- Sensitive:N/A
- Storage Temp.:N/A
- Appearance/Colour:N/A
Acetamide, N-[1-(4-bromophenyl)ethenyl]- Safety information and MSDS
·Hazard identification:
| Pictogram(s) | no data available |
|---|---|
| Signal word | no data available |
| Hazard statement(s) | no data available |
| Precautionary statement(s) | |
| Prevention | no data available |
| Response | no data available |
| Storage | no data available |
| Disposal | no data available |
·Composition/information on ingredients:
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| N-[1-(4-bromophenyl)ethenyl]acetamide | N-[1-(4-bromophenyl)ethenyl]acetamide | 177750-12-8 | none | 100% |
·First-aid measures:
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
·Fire-fighting measures:
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Acetamide, N-[1-(4-bromophenyl)ethenyl]- Relevant articles
All total 32 Articles be found
All total 32 Articles be foundVisible-light-promoted olefinic trifluoromethylation of enamides with CF3SO2Na
Chen, Kai,Chen, Yixuan,Guan, Jianping,Tang, Kai,Wang, Zhujun,Xiang, Haoyue,Yang, Hua
supporting information, p. 7475 - 7479 (2021/09/08)
A visible-light-promoted olefinic C-H trifluoromethylation of enamides was developed by employing cheap and stable Langlois’ reagent as the CF3source. A series of β-CF3enamides were obtained in moderate to good yields with highE-isomer selectivity under mild conditions. Preliminary mechanistic studies suggest that molecular oxygen acts as the terminal oxidant for this net oxidative process, and theEisomer selectivity could be well explained by a base-assisted deprotonation of the cation intermediate.
Selective Dehydrogenative Acylation of Enamides with Aldehydes Leading to Valuable β-Ketoenamides
Liu, Rui-Hua,Shen, Zhen-Yao,Wang, Cong,Loh, Teck-Peng,Hu, Xu-Hong
supporting information, p. 944 - 949 (2020/02/15)
We have presented a unique example of dehydrogenative acylation of enamides with aldehydes enabled by an earth-abundant iron catalyst. The protocol provides the straightforward access to valuable β-ketoenamides with ample substrate scope and excellent functional group tolerance. Notably, distinct C-H acylation of enamide rather than at N-H moiety site occurs with absolute Z-selectivity was observed. Late-stage modifications of complex molecules and versatile synthetic utility of β-ketoenamides further highlight the practicability of this transformation.
Rhodium(III)-Catalyzed Direct C-H Arylation of Various Acyclic Enamides with Arylsilanes
Li, Xiaolan,Sun, Kai,Shen, Wenjuan,Zhang, Yong,Lu, Ming-Zhu,Luo, Xuzhong,Luo, Haiqing
supporting information, p. 31 - 36 (2021/01/09)
The stereoselective β-C(sp2)-H arylation of various acyclic enamides with arylsilanes via Rh(III)-catalyzed cross-coupling reaction was illustrated. The methodology was characterized by extraordinary efficacy and stereoselectivity, a wide scope of substrates, good functional group tolerance, and the adoption of environmentally friendly arylsilanes. The utility of this present method was evidenced by the gram-scale synthesis and further elaboration of the product. In addition, Rh(III)-catalyzed C-H activation is considered to be the critical step in the reaction mechanism.
Direct Enamido C(sp2)?H Diphosphorylation Enabled by a PCET-Triggered Double Radical Relay: Access to gem-Bisphosphonates
Cao, Hao-Qiang,Liu, Hao-Nan,Liu, Zhe-Yuan,Ma, Jun-An,Qiao, Bao-Kun,Zhang, Fa-Guang
supporting information, p. 5515 - 5521 (2020/04/27)
Herein we report a novel and straightforward protocol for the construction of valuable gem-BPs by means of proton-coupled electron-transfer (PCET)-triggered enamido C(sp2)?H diphosphorylation. This reaction represents a rare example of realizing the challenging double C?P bond formation at a single carbon atom, thus providing facile access to a broad variety of structurally diverse bisphosphonates from simple enamides under silver-mediated conditions. Initial mechanistic studies demonstrated that the diphosphorylation involves two rounds of PCET-initiated radical relay process.
Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides
Liu, Rui-Hua,Shan, Qi-Chao,Gao, Ya,Loh, Teck-Peng,Hu, Xu-Hong
supporting information, p. 1411 - 1414 (2020/10/29)
Disclosed herein is an efficient Ag-catalyzed [4 + 1] heteroannulation reaction of enamides with α-carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant tetra-substituted oxazolines is further demonstrated by a series of useful manipulations into valuable building blocks of pharmaceutical relevance.
Acetamide, N-[1-(4-bromophenyl)ethenyl]- Synthetic route And Reaction conditions
| Conditions | Yield |
|---|---|
para-bromoacetophenone;Withtitanium(IV) isopropylate;
ammonia;Inmethanol;
toluene;for 0.166667h;
Inert atmosphere;
Cooling with ice; | 72% |
- 257604-11-8
1-(1-azidoethyl)-4-bromobenzene
- 108-24-7
acetic anhydride
- 177750-12-8
N-{1-(4-bromophenyl)vinyl}acetamide
| Conditions | Yield |
|---|---|
Withdi[(2,4-bis-tert-butyl-1-methoxy-3-neopentylcyclopentadienyl)dichlororuthenium(III)];
triethylamine;
1-butyl-3-methylimidazolium chloride;
at 70 ℃;
for 3h;
Inert atmosphere; | 85% |
Withdi[(2,4-bis-tert-butyl-1-methoxy-3-neopentylcyclopentadienyl)dichlororuthenium(III)];
triethylamine;
1-butyl-3-methylimidazolium chloride;
at 70 ℃;
for 3h;
Inert atmosphere; | 85% |
| Conditions | Yield |
|---|---|
Withtriethylamine;Intetrahydrofuran;at 0 - 25 ℃;
for 12h;
Reagent/catalyst;
Inert atmosphere;
Schlenk technique; | |
- 257604-11-8
1-(1-azidoethyl)-4-bromobenzene
- 177750-12-8
N-{1-(4-bromophenyl)vinyl}acetamide
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: C54H44N2O4Ru2 / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere; Schlenk technique; Irradiation 2: triethylamine / tetrahydrofuran / 12 h / 0 - 25 °C / Inert atmosphere; Schlenk technique |
- 5391-88-8
1-(4-bromophenyl)ethanol
- 177750-12-8
N-{1-(4-bromophenyl)vinyl}acetamide
| Conditions | Yield |
|---|---|
Multi-step reaction with 3 steps 1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenylphosphoranyl azide / toluene / 0 - 25 °C 2: C54H44N2O4Ru2 / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere; Schlenk technique; Irradiation 3: triethylamine / tetrahydrofuran / 12 h / 0 - 25 °C / Inert atmosphere; Schlenk technique |
- 59862-55-4,73744-33-9,5798-71-0
p-bromoacetophenone oxime
- 108-24-7
acetic anhydride
- 64-19-7,77671-22-8
acetic acid
- 177750-12-8
N-{1-(4-bromophenyl)vinyl}acetamide
| Conditions | Yield |
|---|---|
Withsodium dithionite;
iron(II) acetate;
potassium iodide;In1,2-dichloro-ethane;at 65 ℃;
for 1h;
Inert atmosphere; | 71% |
- 59862-55-4,73744-33-9,5798-71-0
p-bromoacetophenone oxime
- 108-24-7
acetic anhydride
- 177750-12-8
N-{1-(4-bromophenyl)vinyl}acetamide
| Conditions | Yield |
|---|---|
| 90% | |
With[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2;
potassium iodide;In1,2-dichloro-ethane;for 3h;
Reflux;
Inert atmosphere; | 89% |
| 80% | |
| 77.9% | |
Withcopper(l) iodide;
sodium hydrogensulfite;In1,2-dichloro-ethane;at 120 ℃;
for 30h;
Inert atmosphere; | 62% |
Withcopper(l) iodide;
sodium hydrogensulfite;In1,2-dichloro-ethane;at 120 ℃;
for 12h;
Inert atmosphere; | |
Withcopper(l) iodide;
sodium hydrogensulfite;In1,2-dichloro-ethane;at 120 ℃;
Schlenk technique;
Inert atmosphere; | |
Withcopper(l) iodide;
sodium hydrogensulfite;In1,2-dichloro-ethane;at 120 ℃;
for 12h;
Inert atmosphere; | |
Withcopper(l) iodide;
sodium hydrogensulfite;In1,2-dichloro-ethane;at 120 ℃;
for 12h;
Inert atmosphere; | |
Withcopper(l) iodide;
sodium hydrogensulfite;In1,2-dichloro-ethane;at 120 ℃;
for 12h;
Inert atmosphere; |
- 5202-78-8,28408-65-3
acetylaminoethylene
- 66107-30-0
4-bromophenyl trifluoromethanesulfonate
- 177750-12-8
N-{1-(4-bromophenyl)vinyl}acetamide
| Conditions | Yield |
|---|---|
| 24% |
- 106-41-2
4-bromo-phenol
- 177750-12-8
N-{1-(4-bromophenyl)vinyl}acetamide
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 20 °C 2: 24 percent / DPPP; Et3N / Pd(OAc)2 / dimethylformamide / 100 °C With1,3-bis-(diphenylphosphino)propane;
triethylamine;palladium diacetate;Indichloromethane;
N,N-dimethyl-formamide;2: Heck reaction; |
- 99-90-1
para-bromoacetophenone
- 177750-12-8
N-{1-(4-bromophenyl)vinyl}acetamide
| Conditions | Yield |
|---|---|
Multi-step reaction with 2 steps 1: NH2OH 2: Fe, HOAc / toluene / 75 °C Withhydroxylamine;
iron;
acetic acid;Intoluene; |
Acetamide, N-[1-(4-bromophenyl)ethenyl]- Raw materials
- 59862-55-4
p-bromoacetophenone oxime
- 108-24-7
acetic anhydride
- 5202-78-8
acetylaminoethylene
- 66107-30-0
4-bromophenyl trifluoromethanesulfonate
- 106-41-2
4-bromo-phenol
Acetamide, N-[1-(4-bromophenyl)ethenyl]- Target Products
Business Type:
- Lab/Research institutionsTrading CompanyManufacturers
Certificate:
- Product LicenseEnterprise AuthenticationISOGMPFDAHALAL
Country :
China (Mainland)(1)
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- Total:1 Page 1 of 1 1
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