Mannidex 16700;Hexahydroxyhexane;hexane-1,2,3,4,5,6-hexol;
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Bangladesh(1)
Brazil(1)1. Introduction of Mannitol
Mannitol , with CAS number of 87-78-5, can be called Hexahydroxyhexane; DL-Mannitol; (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol; hexane-1,2,3,4,5,6-hexol. Mannitol is analytics reagents, also used for resin and drug synthesis.
2. Properties of Mannitol
Mannitol has the following datas: (1)H bond acceptors: 6; (2)H bond donors: 6; (3)Freely Rotating Bonds: 11; (4)Polar Surface Area: 55.38 ?2; (5)Index of Refraction: 1.597; (6)Molar Refractivity: 38.89 cm3; (7)Molar Volume: 114.1 cm3; (8)Surface Tension: 99.8 dyne/cm; (9)Density: 1.596 g/cm3; (10)Flash Point: 292.5 °C; (11)Enthalpy of Vaporization: 87.81 kJ/mol; (12)Boiling Point: 494.9 °C at 760 mmHg; (13)Vapour Pressure: 7.22E-12 mmHg at 25°C.
3. Structure Descriptors of Mannitol
You could convert the following datas into the molecular structure:
InChI
InChI=1/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
Smiles
OC[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
4. Toxicity of Mannitol
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | intravenous | 5714mg/kg (5714mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Nephron. Vol. 45, Pg. 233, 1987. |
| rat | LD50 | intravenous | 25800uL/kg (25.8mL/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967. |
