- CAS Number:1801-10-1
- Molecular Formula:C8H6F3NO
- Molecular Weight:189.137
- Mol File:1801-10-1.mol
- Melting Point:124-127 °C(lit.)
- Boiling Point:241.3 °C at 760 mmHg
- Density:1.335 g/cm3
- Flash Point:99.7 °C
- Vapor Density:N/A
- Refractive Index:1.478
- Storage Temp.:N/A
- Appearance/Colour:White to light yellow crystal powder
m-(Trifluoromethyl)benzamide Safety information and MSDS
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
·Composition/information on ingredients:
|Chemical name||Common names and synonyms||CAS number||EC number||Concentration|
General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.
·Accidental release measures:
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.
m-(Trifluoromethyl)benzamide Relevant articlesAll total 24 Articles be found
Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes
Chen, Xuenian,Kang, Jia-Xin,Ma, Yan-Na,Miao, Yu-Qi
supporting information, p. 3595 - 3599 (2021/06/06)
Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.
Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: Synthesis of primary amides
Kamble, Rohit B.,Mane, Kishor D.,Rupanawar, Bapurao D.,Korekar, Pranjal,Sudalai,Suryavanshi, Gurunath
, p. 724 - 728 (2020/01/23)
A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.
Tandem synthesis of aromatic amides from styrenes in water
Sathe, Pratima A.,Karpe, Aniket S.,Parab, Aniket A.,Parade, Babasao S.,Vadagaonkar, Kamlesh S.,Chaskar, Atul C.
supporting information, p. 2820 - 2823 (2018/06/25)
An expedient one-pot synthesis of aromatic amides has been reported from styrenes in the presence of N-bromosuccinimide and iodine by using aqueous ammonia in water. The reaction proceeds through the formation of α-bromoketone as an intermediate in the presence of NBS and water. α-Bromoketone on reaction with iodine forms bromodiiodoketone which on nucleophilic substitution with aqueous ammonia gives aromatic amide. Substituted aromatic amides were obtained in good yields with wide functional group compatibility.
Chemoselective Synthesis of Aryl Ketones from Amides and Grignard Reagents via C(O)-N Bond Cleavage under Catalyst-Free Conditions
Sureshbabu, Popuri,Azeez, Sadaf,Muniyappan, Nalluchamy,Sabiah, Shahulhameed,Kandasamy, Jeyakumar
, p. 11823 - 11838 (2019/10/02)
Conversion of a wide range of N-Boc amides to aryl ketones was achieved with Grignard reagents via chemoselective C(O)-N bond cleavage. The reactions proceeded under catalyst-free conditions with different aryl, alkyl, and alkynyl Grignard reagents. α-Ketoamide was successfully converted to aryl diketones, while α,β-unsaturated amide underwent 1,4-addition followed by C(O)-N bond cleavage to provide diaryl propiophenones. N-Boc amides displayed higher reactivity than Weinreb amides with Grignard reagents. A broad substrate scope, excellent yields, and quick conversion are important features of this methodology.
Base promoted peroxide systems for the efficient synthesis of nitroarenes and benzamides
Gupta, Sampa,Ansari, Alisha,Sashidhara, Koneni V.
supporting information, (2019/09/07)
A useful and efficient approach for the synthesis of nitroarenes from several aromatic amines (including heterocycles) using peroxide and base has been developed. This oxidative reaction is very easy to handle and afforded the products in good yields. Formation of benzamides from benzylamine was also successfully carried out with this metal-free catalytic system in good to excellent yields.
m-(Trifluoromethyl)benzamide Synthetic route And Reaction conditions
Nitril III, aq. HCl;
3-Trifluormethyl-benzoylchlorid, konz. wss. NH3;
α,α,α-Trifluor-m-toluylsaeure, 1) SOCl2, 2) NH4OH;
Withdmap; formamide; triphenylphosphine;palladium diacetate;at 120 ℃; for 18h; under 3750.38 Torr; Further Variations:; Temperatures; Pressures; Reagents; Solvents; catalysts, reaction times; Product distribution;
Withdichloro bis(acetonitrile) palladium(II); ammonium bicarbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;Inacetonitrile;at 120 ℃; for 12h; under 7500.75 Torr; Autoclave;
|> 99 %Chromat.|
Withdmap; bis-triphenylphosphine-palladium(II) chloride;In1,4-dioxane;at 120 ℃; for 2h; under 3750.38 Torr; Further byproducts.;
Withbis-triphenylphosphine-palladium(II) chloride; triethylamine;In1,4-dioxane;at 120 ℃; for 8h; under 3750.38 Torr;
Withdmap; bis-triphenylphosphine-palladium(II) chloride; carbon monoxide;In1,4-dioxane;at 120 ℃; for 18h; under 3750.38 Torr;
- diethylene glycol dibutylether
diethylene glycol dibutylether
Withammonium hydroxide; at 20 ℃; for 0.5h;
Withammonium hydroxide;Indichloromethane;at 0 - 20 ℃; for 3.5h;
Withdmap; triethylamine;Indichloromethane;at 0 - 20 ℃; for 15h; Inert atmosphere;
With2,4,6-trimethyl-pyridine; copper diacetate;InN,N-dimethyl acetamide;at 25 ℃; for 16h; under 760.051 Torr; Inert atmosphere;
3-trifluoromethylbenzonitrile;Withcaesium carbonate;In2-pyrrolidinon;at 130 ℃; for 2h; Sealed vessel;
Withmethanol;In2-pyrrolidinon; dichloromethane;at 20 ℃; Filtering through Celite pad;
Withwater; sodium hydroxide;Inethanol;at 90 ℃; for 17h;
m-(Trifluoromethyl)benzamide Raw materials
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